HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/96911 https://doi.org/10.3390/curroncol29010005 |
Resumo: | Gastric cancer is a serious health problem worldwide. Although its incidence is decreasing, the five-year survival rate remains low. Thus, it is essential to identify new biomarkers that could promote better diagnosis and treatment of patients with gastric cancer. High-mobility group AT-hook 1 (HMGA1) is a non-histone, chromatin-binding protein that has been found overexpressed in several tumor types. It has been correlated with invasion, metastasis, and drug resistance, leading to worse patient survival. The aim of this work was to evaluate the clinical value of HMGA1 in gastric cancer. HMGA1 expression was analyzed by immunohistochemistry in a single hospital series (n = 323) of gastric adenocarcinoma cases (stages I to IV) with clinicopathological and treatment data. In this series, HMGA1 expression showed no significant relevance as a prognostic biomarker. Nevertheless, a significantly better overall survival was observed in cases with high levels of HMGA1 when they were treated with chemotherapy, compared to the nontreated ones, implying that they can benefit more from treatment than patients with low expression of HMGA1. We thereby show for the first time that HMGA1 expression has a substantial value as a biomarker of response to chemotherapy in gastric cancer. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
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HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric CancerChemotherapyGastric cancerHMGA1Predictive valuePrognosisGastric cancer is a serious health problem worldwide. Although its incidence is decreasing, the five-year survival rate remains low. Thus, it is essential to identify new biomarkers that could promote better diagnosis and treatment of patients with gastric cancer. High-mobility group AT-hook 1 (HMGA1) is a non-histone, chromatin-binding protein that has been found overexpressed in several tumor types. It has been correlated with invasion, metastasis, and drug resistance, leading to worse patient survival. The aim of this work was to evaluate the clinical value of HMGA1 in gastric cancer. HMGA1 expression was analyzed by immunohistochemistry in a single hospital series (n = 323) of gastric adenocarcinoma cases (stages I to IV) with clinicopathological and treatment data. In this series, HMGA1 expression showed no significant relevance as a prognostic biomarker. Nevertheless, a significantly better overall survival was observed in cases with high levels of HMGA1 when they were treated with chemotherapy, compared to the nontreated ones, implying that they can benefit more from treatment than patients with low expression of HMGA1. We thereby show for the first time that HMGA1 expression has a substantial value as a biomarker of response to chemotherapy in gastric cancer. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.MDPI2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/96911http://hdl.handle.net/10316/96911https://doi.org/10.3390/curroncol29010005eng1718-7729Pádua, DianaPinto, Débora FilipaFigueira, PaulaPereira, Carlos FilipeAlmeida, RaquelMesquita, Patríciainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T06:35:03Zoai:estudogeral.uc.pt:10316/96911Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:15:04.776433Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer |
title |
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer |
spellingShingle |
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer Pádua, Diana Chemotherapy Gastric cancer HMGA1 Predictive value Prognosis |
title_short |
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer |
title_full |
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer |
title_fullStr |
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer |
title_full_unstemmed |
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer |
title_sort |
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer |
author |
Pádua, Diana |
author_facet |
Pádua, Diana Pinto, Débora Filipa Figueira, Paula Pereira, Carlos Filipe Almeida, Raquel Mesquita, Patrícia |
author_role |
author |
author2 |
Pinto, Débora Filipa Figueira, Paula Pereira, Carlos Filipe Almeida, Raquel Mesquita, Patrícia |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pádua, Diana Pinto, Débora Filipa Figueira, Paula Pereira, Carlos Filipe Almeida, Raquel Mesquita, Patrícia |
dc.subject.por.fl_str_mv |
Chemotherapy Gastric cancer HMGA1 Predictive value Prognosis |
topic |
Chemotherapy Gastric cancer HMGA1 Predictive value Prognosis |
description |
Gastric cancer is a serious health problem worldwide. Although its incidence is decreasing, the five-year survival rate remains low. Thus, it is essential to identify new biomarkers that could promote better diagnosis and treatment of patients with gastric cancer. High-mobility group AT-hook 1 (HMGA1) is a non-histone, chromatin-binding protein that has been found overexpressed in several tumor types. It has been correlated with invasion, metastasis, and drug resistance, leading to worse patient survival. The aim of this work was to evaluate the clinical value of HMGA1 in gastric cancer. HMGA1 expression was analyzed by immunohistochemistry in a single hospital series (n = 323) of gastric adenocarcinoma cases (stages I to IV) with clinicopathological and treatment data. In this series, HMGA1 expression showed no significant relevance as a prognostic biomarker. Nevertheless, a significantly better overall survival was observed in cases with high levels of HMGA1 when they were treated with chemotherapy, compared to the nontreated ones, implying that they can benefit more from treatment than patients with low expression of HMGA1. We thereby show for the first time that HMGA1 expression has a substantial value as a biomarker of response to chemotherapy in gastric cancer. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/96911 http://hdl.handle.net/10316/96911 https://doi.org/10.3390/curroncol29010005 |
url |
http://hdl.handle.net/10316/96911 https://doi.org/10.3390/curroncol29010005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1718-7729 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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