Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering

Detalhes bibliográficos
Autor(a) principal: Quraishi, Sakeena
Data de Publicação: 2015
Outros Autores: Martins, Marta, Barros, Alexandre A., Gurikov, Pavel, Raman, S. P., Smirnova, Irina, Duarte, Ana Rita C., Reis, R. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/38374
Resumo: uncorrected proof
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spelling Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineeringAlginateBiomaterialsLigninScaffoldsSupercriticalTissue engineeringCiências Médicas::Biotecnologia MédicaScience & Technologyuncorrected proofThis paper presents a novel approach towards the production of hybrid alginate-lignin aerogels. The key idea of the approach is to employ pressurized carbon dioxide for gelation. Exposure of alginate and lignin solution containing calcium carbonate to CO2 at 4.5 MPa resulted in a hydrogel formation. Various lignin and CaCO3 concentrations were studied. Stable hydrogels can be formed up to 2:1 (w/w) alginate-to-lignin ratio. Upon substitution of water with ethanol, gels were dried in supercritical CO2 to produce aerogels. Aerogels were characterized in terms of bulk density, specific surface area and pore volume. To introduce macroporosity, the CO2 induced gelation was supplemented with rapid depressurization (foaming process). Porosity, mean pore size and interconnectivity in the macroporous range were assessed by micro-CT. Youngâ s modulus of alginate-lignin aerogels was measured in both dry and wet state. Cell studies revealed that alginate-lignin aerogels are non-cytotoxic and demonstrate good cell adhesion properties making them attractive candidates for a wide range of applications including tissue engineering and regenerative medicine.Fundação da Ciência e Tecnologia (FCT) through the project ENIGMA – PTDC/EQU-EPR/121491/2010, and from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. REGPOT-CT2012-316331-POLARIS and from Project “Novel smart and biomimetic materials for innovative regenerative medicine approaches (Ref.: RL1 – ABMR – NORTE-01-0124-FEDER-000016)” cofinanced by North Portugal Regional Operational Programme (ON.2-O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF) and FEDER. Fundação da Ciência e Tecnologia (FCT) through the grant BIM/PTDC/EQU-EPR/121491/2010/ENIGMA, bilateral cooperation project FCT-DAAD 57036335, and from DFG (projects SM 82/8-1 and SM 82/8-2).ElsevierUniversidade do MinhoQuraishi, SakeenaMartins, MartaBarros, Alexandre A.Gurikov, PavelRaman, S. P.Smirnova, IrinaDuarte, Ana Rita C.Reis, R. L.2015-102015-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/38374engQuraishi S., Martins M., Barros A. A., Gurikova P., Raman S. P., Smirnova I., Duarte A. R. C., Reis R. L. Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering, The Journal of Supercritical Fluids, Vol. 105, pp. 1-8, doi:10.1016/j.supflu.2014.12.026, 20150896-844610.1016/j.supflu.2014.12.026http://www.sciencedirect.com/science/article/pii/S0896844615000133info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:16:13Zoai:repositorium.sdum.uminho.pt:1822/38374Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:08:44.247263Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering
title Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering
spellingShingle Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering
Quraishi, Sakeena
Alginate
Biomaterials
Lignin
Scaffolds
Supercritical
Tissue engineering
Ciências Médicas::Biotecnologia Médica
Science & Technology
title_short Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering
title_full Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering
title_fullStr Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering
title_full_unstemmed Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering
title_sort Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering
author Quraishi, Sakeena
author_facet Quraishi, Sakeena
Martins, Marta
Barros, Alexandre A.
Gurikov, Pavel
Raman, S. P.
Smirnova, Irina
Duarte, Ana Rita C.
Reis, R. L.
author_role author
author2 Martins, Marta
Barros, Alexandre A.
Gurikov, Pavel
Raman, S. P.
Smirnova, Irina
Duarte, Ana Rita C.
Reis, R. L.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Quraishi, Sakeena
Martins, Marta
Barros, Alexandre A.
Gurikov, Pavel
Raman, S. P.
Smirnova, Irina
Duarte, Ana Rita C.
Reis, R. L.
dc.subject.por.fl_str_mv Alginate
Biomaterials
Lignin
Scaffolds
Supercritical
Tissue engineering
Ciências Médicas::Biotecnologia Médica
Science & Technology
topic Alginate
Biomaterials
Lignin
Scaffolds
Supercritical
Tissue engineering
Ciências Médicas::Biotecnologia Médica
Science & Technology
description uncorrected proof
publishDate 2015
dc.date.none.fl_str_mv 2015-10
2015-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/38374
url http://hdl.handle.net/1822/38374
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Quraishi S., Martins M., Barros A. A., Gurikova P., Raman S. P., Smirnova I., Duarte A. R. C., Reis R. L. Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering, The Journal of Supercritical Fluids, Vol. 105, pp. 1-8, doi:10.1016/j.supflu.2014.12.026, 2015
0896-8446
10.1016/j.supflu.2014.12.026
http://www.sciencedirect.com/science/article/pii/S0896844615000133
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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