Association of S100B Serum Levels with Metabolic Syndrome and its Components
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073 |
Resumo: | Introduction: We aimed to compare serum levels of S100B between patients with metabolic syndrome and healthy subjects and to investigate the association of S100B with components of the metabolic syndrome.Materials and Methods: In this study, 44 patients with metabolic syndrome and 44 healthy subjects participated. The participants’ body mass index, waist circumference, systolic and diastolic blood pressure were measured. Serum levels of low and high density lipoprotein cholesterol, total cholesterol, triglyceride, fasting blood glucose, insulin, S100B protein were determined by enzymatic and ELISA methods.Results: The participants with metabolic syndrome had significantly higher levels of S100B than those in the control group (p < 0.0001). Serum levels of S100B protein were positively correlated with abdominal obesity (rho = 0.26; p = 0.01) and serum levels of triglyceride (rho = 0.26; p = 0.01). Moreover, serum levels of S100B were higher in subjects with abdominal obesity (p = 0.02), with higher serum triglyceride levels (p = 0.03) and with hypertension (p = 0.01).Conclusion: The findings indicate that there may be a link between S100B protein with abdominal obesity and serum levels of triglycerides. This warrants further research to elucidate whether increased S100B levels in patients with metabolic syndrome are involved in the pathogenesis of cardiovascular disorders. |
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Association of S100B Serum Levels with Metabolic Syndrome and its ComponentsAssociação dos Níveis de Soro S100B com a Síndrome Metabólica e seus ComponentesMetabolic SyndromeObesityAbdominalS100 Calcium Binding Protein beta SubunitObesidade AbdominalSíndrome MetabólicaSubunidade beta da Proteína Ligante de Cálcio S100Introduction: We aimed to compare serum levels of S100B between patients with metabolic syndrome and healthy subjects and to investigate the association of S100B with components of the metabolic syndrome.Materials and Methods: In this study, 44 patients with metabolic syndrome and 44 healthy subjects participated. The participants’ body mass index, waist circumference, systolic and diastolic blood pressure were measured. Serum levels of low and high density lipoprotein cholesterol, total cholesterol, triglyceride, fasting blood glucose, insulin, S100B protein were determined by enzymatic and ELISA methods.Results: The participants with metabolic syndrome had significantly higher levels of S100B than those in the control group (p < 0.0001). Serum levels of S100B protein were positively correlated with abdominal obesity (rho = 0.26; p = 0.01) and serum levels of triglyceride (rho = 0.26; p = 0.01). Moreover, serum levels of S100B were higher in subjects with abdominal obesity (p = 0.02), with higher serum triglyceride levels (p = 0.03) and with hypertension (p = 0.01).Conclusion: The findings indicate that there may be a link between S100B protein with abdominal obesity and serum levels of triglycerides. This warrants further research to elucidate whether increased S100B levels in patients with metabolic syndrome are involved in the pathogenesis of cardiovascular disorders.Introdução: O nosso objetivo foi comparar os níveis séricos de S100B entre pacientes com síndrome metabólica e indivíduos saudáveis e investigar a associação de S100B com os componentes da síndrome metabólica.Material e Métodos: Neste estudo participaram 44 pacientes com síndrome metabólica e 44 indivíduos saudáveis. Foram medidos o índice de massa corporal, o perímetro abdominal, pressão arterial sistólica e diastólica dos participantes. Os níveis séricos de colesterol de lipoproteínas de baixa e alta densidade, colesterol total, triglicerídos, glicemia em jejum, insulina, proteína S100B foram determinados por métodos enzimáticos e ELISA.Resultados: Os participantes com síndrome metabólica apresentaram níveis significativamente mais altos de S100B do que os do grupo de controlo (p < 0,0001). Os níveis séricos de proteína S100B foram positivamente correlacionados com obesidade abdominal (rho = 0,26; p = 0,01) e níveis séricos de triglicéridos (rho = 0,26; p = 0,01). Além disso, os níveis séricos de S100B foram mais elevados em indivíduos com obesidade abdominal (p = 0,02), com níveis mais elevados de triglicéridos no soro (p = 0,03) e com hipertensão (p = 0,01).Conclusão: Os resultados indicam que pode haver uma ligação entre a proteína S100B com obesidade e níveis séricos de triglicéridos. Isso implica a necessidade de mais estudos para elucidar se o aumento dos níveis de S100B em pacientes com síndrome metabólica está envolvido na patogénese de doenças cardiovasculares.Ordem dos Médicos2018-04-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/mswordhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073oai:ojs.www.actamedicaportuguesa.com:article/9073Acta Médica Portuguesa; Vol. 31 No. 4 (2018): April; 201-206Acta Médica Portuguesa; Vol. 31 N.º 4 (2018): Abril; 201-2061646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073/5407https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073/9414https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073/9697https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073/10005Direitos de Autor (c) 2018 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessKheirouri, SorayyaEbrahimi, ElhamAlizadeh, Mohammad2022-12-20T11:05:41Zoai:ojs.www.actamedicaportuguesa.com:article/9073Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:40.544215Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Association of S100B Serum Levels with Metabolic Syndrome and its Components Associação dos Níveis de Soro S100B com a Síndrome Metabólica e seus Componentes |
title |
Association of S100B Serum Levels with Metabolic Syndrome and its Components |
spellingShingle |
Association of S100B Serum Levels with Metabolic Syndrome and its Components Kheirouri, Sorayya Metabolic Syndrome Obesity Abdominal S100 Calcium Binding Protein beta Subunit Obesidade Abdominal Síndrome Metabólica Subunidade beta da Proteína Ligante de Cálcio S100 |
title_short |
Association of S100B Serum Levels with Metabolic Syndrome and its Components |
title_full |
Association of S100B Serum Levels with Metabolic Syndrome and its Components |
title_fullStr |
Association of S100B Serum Levels with Metabolic Syndrome and its Components |
title_full_unstemmed |
Association of S100B Serum Levels with Metabolic Syndrome and its Components |
title_sort |
Association of S100B Serum Levels with Metabolic Syndrome and its Components |
author |
Kheirouri, Sorayya |
author_facet |
Kheirouri, Sorayya Ebrahimi, Elham Alizadeh, Mohammad |
author_role |
author |
author2 |
Ebrahimi, Elham Alizadeh, Mohammad |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Kheirouri, Sorayya Ebrahimi, Elham Alizadeh, Mohammad |
dc.subject.por.fl_str_mv |
Metabolic Syndrome Obesity Abdominal S100 Calcium Binding Protein beta Subunit Obesidade Abdominal Síndrome Metabólica Subunidade beta da Proteína Ligante de Cálcio S100 |
topic |
Metabolic Syndrome Obesity Abdominal S100 Calcium Binding Protein beta Subunit Obesidade Abdominal Síndrome Metabólica Subunidade beta da Proteína Ligante de Cálcio S100 |
description |
Introduction: We aimed to compare serum levels of S100B between patients with metabolic syndrome and healthy subjects and to investigate the association of S100B with components of the metabolic syndrome.Materials and Methods: In this study, 44 patients with metabolic syndrome and 44 healthy subjects participated. The participants’ body mass index, waist circumference, systolic and diastolic blood pressure were measured. Serum levels of low and high density lipoprotein cholesterol, total cholesterol, triglyceride, fasting blood glucose, insulin, S100B protein were determined by enzymatic and ELISA methods.Results: The participants with metabolic syndrome had significantly higher levels of S100B than those in the control group (p < 0.0001). Serum levels of S100B protein were positively correlated with abdominal obesity (rho = 0.26; p = 0.01) and serum levels of triglyceride (rho = 0.26; p = 0.01). Moreover, serum levels of S100B were higher in subjects with abdominal obesity (p = 0.02), with higher serum triglyceride levels (p = 0.03) and with hypertension (p = 0.01).Conclusion: The findings indicate that there may be a link between S100B protein with abdominal obesity and serum levels of triglycerides. This warrants further research to elucidate whether increased S100B levels in patients with metabolic syndrome are involved in the pathogenesis of cardiovascular disorders. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-04-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073 oai:ojs.www.actamedicaportuguesa.com:article/9073 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/9073 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073/5407 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073/9414 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073/9697 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9073/10005 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2018 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2018 Acta Médica Portuguesa |
eu_rights_str_mv |
openAccess |
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application/pdf application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document application/msword |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 31 No. 4 (2018): April; 201-206 Acta Médica Portuguesa; Vol. 31 N.º 4 (2018): Abril; 201-206 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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