Growing old, yet staying young: the role of telomeres in bat's exceptional longevity

Detalhes bibliográficos
Autor(a) principal: Foley, Nicole M.
Data de Publicação: 2018
Outros Autores: Hughes, Graham M., Huang, Zixia, Clarke, Michael, Jebb, David, Whelan, Conor V., Petit, Eric J., Touzalin, Frédéric, Farcy, Olivier, Jones, Gareth, Ransome, Roger D., Kacprzyk, Joanna, O'Connell, Mary J., Kerth, Gerald, Rebelo, Hugo, Rodrigues, Luísa, Puechmaille, Sébastien J., Teeling, Emma C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/15040
Resumo: Research Article - Genetics
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spelling Growing old, yet staying young: the role of telomeres in bat's exceptional longevitybattelomereslongevityResearch Article - GeneticsUnderstanding aging is a grand challenge in biology. Exceptionally long-lived animals have mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats on chromosome tips that shorten with cell division, potentially limiting life span. Bats are the longest-lived mammals for their size, but it is unknown whether their telomeres shorten. Using >60 years of cumulative mark-recapture field data, we show that telomeres shorten with age in Rhinolophus ferrumequinum andMiniopterus schreibersii, but not in the bat genus with greatest longevity, Myotis. As in humans, telomerase is not expressed in Myotis myotis blood or fibroblasts. Selection tests on telomere maintenance genes show that ATM and SETX, which repair and prevent DNA damage, potentially mediate telomere dynamics in Myotis bats. Twenty-one telomere maintenance genes are differentially expressed in Myotis, ofwhich 14 are enriched for DNA repair, and 5 for alternative telomere-lengthening mechanisms. We demonstrate how telomeres, telomerase, and DNA repair genes have contributed to the evolution of exceptional longevity in Myotis bats, advancing our understanding of healthy agingAAASRepositório da Universidade de LisboaFoley, Nicole M.Hughes, Graham M.Huang, ZixiaClarke, MichaelJebb, DavidWhelan, Conor V.Petit, Eric J.Touzalin, FrédéricFarcy, OlivierJones, GarethRansome, Roger D.Kacprzyk, JoannaO'Connell, Mary J.Kerth, GeraldRebelo, HugoRodrigues, LuísaPuechmaille, Sébastien J.Teeling, Emma C.2018-03-05T14:58:49Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/15040engFoley et al., Sci. Adv. 2018;4: eaao0926info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:45:01Zoai:www.repository.utl.pt:10400.5/15040Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:00:47.252201Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Growing old, yet staying young: the role of telomeres in bat's exceptional longevity
title Growing old, yet staying young: the role of telomeres in bat's exceptional longevity
spellingShingle Growing old, yet staying young: the role of telomeres in bat's exceptional longevity
Foley, Nicole M.
bat
telomeres
longevity
title_short Growing old, yet staying young: the role of telomeres in bat's exceptional longevity
title_full Growing old, yet staying young: the role of telomeres in bat's exceptional longevity
title_fullStr Growing old, yet staying young: the role of telomeres in bat's exceptional longevity
title_full_unstemmed Growing old, yet staying young: the role of telomeres in bat's exceptional longevity
title_sort Growing old, yet staying young: the role of telomeres in bat's exceptional longevity
author Foley, Nicole M.
author_facet Foley, Nicole M.
Hughes, Graham M.
Huang, Zixia
Clarke, Michael
Jebb, David
Whelan, Conor V.
Petit, Eric J.
Touzalin, Frédéric
Farcy, Olivier
Jones, Gareth
Ransome, Roger D.
Kacprzyk, Joanna
O'Connell, Mary J.
Kerth, Gerald
Rebelo, Hugo
Rodrigues, Luísa
Puechmaille, Sébastien J.
Teeling, Emma C.
author_role author
author2 Hughes, Graham M.
Huang, Zixia
Clarke, Michael
Jebb, David
Whelan, Conor V.
Petit, Eric J.
Touzalin, Frédéric
Farcy, Olivier
Jones, Gareth
Ransome, Roger D.
Kacprzyk, Joanna
O'Connell, Mary J.
Kerth, Gerald
Rebelo, Hugo
Rodrigues, Luísa
Puechmaille, Sébastien J.
Teeling, Emma C.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Foley, Nicole M.
Hughes, Graham M.
Huang, Zixia
Clarke, Michael
Jebb, David
Whelan, Conor V.
Petit, Eric J.
Touzalin, Frédéric
Farcy, Olivier
Jones, Gareth
Ransome, Roger D.
Kacprzyk, Joanna
O'Connell, Mary J.
Kerth, Gerald
Rebelo, Hugo
Rodrigues, Luísa
Puechmaille, Sébastien J.
Teeling, Emma C.
dc.subject.por.fl_str_mv bat
telomeres
longevity
topic bat
telomeres
longevity
description Research Article - Genetics
publishDate 2018
dc.date.none.fl_str_mv 2018-03-05T14:58:49Z
2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/15040
url http://hdl.handle.net/10400.5/15040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Foley et al., Sci. Adv. 2018;4: eaao0926
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv AAAS
publisher.none.fl_str_mv AAAS
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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