Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/40295 |
Resumo: | Previous studies on monocarboxylate transporters expression in prostate cancer (PCa) have shown that monocarboxylate transporter 2 (MCT2) was clearly overexpressed in prostate malignant glands, pointing it out as a putative biomarker for PCa. However, its localization and possible role in PCa cells remained unclear. In this study, we demonstrate that MCT2 localizes mainly at peroxisomes in PCa cells and is able to take advantage of the peroxisomal transport machinery by interacting with Pex19. We have also shown an increase in MCT2 expression from non-malignant to malignant cells that was directly correlated with its peroxisomal localization. Upon analysis of the expression of several peroxisomal ß-oxidation proteins in PIN lesions and PCa cells from a large variety of human prostate samples, we suggest that MCT2 presence at peroxisomes is related to an increase in ß -oxidation levels which may be crucial for malignant transformation. Our results present novel evidence that may not only contribute to the study of PCa development mechanisms but also pinpoint novel targets for cancer therapy. |
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Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancerPeroxisomesMCT2Prostate cancerScience & TechnologyPrevious studies on monocarboxylate transporters expression in prostate cancer (PCa) have shown that monocarboxylate transporter 2 (MCT2) was clearly overexpressed in prostate malignant glands, pointing it out as a putative biomarker for PCa. However, its localization and possible role in PCa cells remained unclear. In this study, we demonstrate that MCT2 localizes mainly at peroxisomes in PCa cells and is able to take advantage of the peroxisomal transport machinery by interacting with Pex19. We have also shown an increase in MCT2 expression from non-malignant to malignant cells that was directly correlated with its peroxisomal localization. Upon analysis of the expression of several peroxisomal ß-oxidation proteins in PIN lesions and PCa cells from a large variety of human prostate samples, we suggest that MCT2 presence at peroxisomes is related to an increase in ß -oxidation levels which may be crucial for malignant transformation. Our results present novel evidence that may not only contribute to the study of PCa development mechanisms but also pinpoint novel targets for cancer therapy.SFRH/BPD/77619/2011PTDC-IMI-MIC-0828-2012Portuguese Foundation for Science and Technology (FCT), refs. SFRH/BD/61027/2009Wiley-BlackwellUniversidade do MinhoValença, IsabelPértega-Gomes, NelmaRámon Vizcaino, JoséHenrique, Rui M.Lopes, CarlosBaltazar, FátimaRibeiro, Daniela20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40295engValenca, I., Pertega-Gomes, N., Vizcaino, J. R., Henrique, R. M., Lopes, C., Baltazar, F., & Ribeiro, D. (2015). Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer. Journal of Cellular and Molecular Medicine, 19(4), 723-733. doi: 10.1111/jcmm.124811582-493410.1111/jcmm.1248125639644http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12481/abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:42:10Zoai:repositorium.sdum.uminho.pt:1822/40295Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:39:21.179351Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer |
title |
Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer |
spellingShingle |
Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer Valença, Isabel Peroxisomes MCT2 Prostate cancer Science & Technology |
title_short |
Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer |
title_full |
Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer |
title_fullStr |
Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer |
title_full_unstemmed |
Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer |
title_sort |
Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer |
author |
Valença, Isabel |
author_facet |
Valença, Isabel Pértega-Gomes, Nelma Rámon Vizcaino, José Henrique, Rui M. Lopes, Carlos Baltazar, Fátima Ribeiro, Daniela |
author_role |
author |
author2 |
Pértega-Gomes, Nelma Rámon Vizcaino, José Henrique, Rui M. Lopes, Carlos Baltazar, Fátima Ribeiro, Daniela |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Valença, Isabel Pértega-Gomes, Nelma Rámon Vizcaino, José Henrique, Rui M. Lopes, Carlos Baltazar, Fátima Ribeiro, Daniela |
dc.subject.por.fl_str_mv |
Peroxisomes MCT2 Prostate cancer Science & Technology |
topic |
Peroxisomes MCT2 Prostate cancer Science & Technology |
description |
Previous studies on monocarboxylate transporters expression in prostate cancer (PCa) have shown that monocarboxylate transporter 2 (MCT2) was clearly overexpressed in prostate malignant glands, pointing it out as a putative biomarker for PCa. However, its localization and possible role in PCa cells remained unclear. In this study, we demonstrate that MCT2 localizes mainly at peroxisomes in PCa cells and is able to take advantage of the peroxisomal transport machinery by interacting with Pex19. We have also shown an increase in MCT2 expression from non-malignant to malignant cells that was directly correlated with its peroxisomal localization. Upon analysis of the expression of several peroxisomal ß-oxidation proteins in PIN lesions and PCa cells from a large variety of human prostate samples, we suggest that MCT2 presence at peroxisomes is related to an increase in ß -oxidation levels which may be crucial for malignant transformation. Our results present novel evidence that may not only contribute to the study of PCa development mechanisms but also pinpoint novel targets for cancer therapy. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/40295 |
url |
http://hdl.handle.net/1822/40295 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Valenca, I., Pertega-Gomes, N., Vizcaino, J. R., Henrique, R. M., Lopes, C., Baltazar, F., & Ribeiro, D. (2015). Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer. Journal of Cellular and Molecular Medicine, 19(4), 723-733. doi: 10.1111/jcmm.12481 1582-4934 10.1111/jcmm.12481 25639644 http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12481/abstract |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132934432620544 |