Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4309 |
Resumo: | Purpose: We aimed to study the effect of FB in the outcomes of critically-ill patients with cirrhosis. Materials: Retrospective analysis of all adult consecutive admissions of patients with cirrhosis and organ failures to the Intensive Care Unit (ICU) at Curry Cabral Hospital (Lisbon, Portugal) and University of Alberta Hospital (Edmonton, Canada) on 08/2013-08/2017. Primary exposure was FB at 3 and 7 days post ICU admission. Primary endpoint was hospital mortality. Results: Amongst 333 patients, median age was 56 years and 67.6% were men. Median MELD, APACHEII, CLIF-SOFA, and CLIF-C-ACLF scores on ICU admission were 27, 28, 14, and 54, respectively. ICU and hospital mortality rates were 33.0% and 49.2%, respectively. While median FB at 3 days post ICU admission (+5.46 l vs. +6.62 l; P = 0.74) was not associated with hospital mortality, higher median FB at 7 days post ICU admission (+13.50 l vs. +6.90 l; P = 0.036) was associated with higher hospital mortality. This association remained significant (OR 95%CI = 1.04 [1.01;1.07] per each l) after adjustment for confounders (age, ascites, infection, lactate, and number of organ failures). Conclusions: FB may be a therapeutic target that helps to improve the outcomes of patients with acute-on-chronic liver failure. This data may inform future clinical trials. |
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Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort StudyHCC CIRHCC GASHCC UCIHumansAdultMaleMiddle AgedAcute-On-Chronic Liver Failure*Cohort StudiesIntensive Care UnitsPrognosisLiver CirrhosisROC CurveOrgan Dysfunction ScoresRetrospective StudiesWater-Electrolyte BalancePurpose: We aimed to study the effect of FB in the outcomes of critically-ill patients with cirrhosis. Materials: Retrospective analysis of all adult consecutive admissions of patients with cirrhosis and organ failures to the Intensive Care Unit (ICU) at Curry Cabral Hospital (Lisbon, Portugal) and University of Alberta Hospital (Edmonton, Canada) on 08/2013-08/2017. Primary exposure was FB at 3 and 7 days post ICU admission. Primary endpoint was hospital mortality. Results: Amongst 333 patients, median age was 56 years and 67.6% were men. Median MELD, APACHEII, CLIF-SOFA, and CLIF-C-ACLF scores on ICU admission were 27, 28, 14, and 54, respectively. ICU and hospital mortality rates were 33.0% and 49.2%, respectively. While median FB at 3 days post ICU admission (+5.46 l vs. +6.62 l; P = 0.74) was not associated with hospital mortality, higher median FB at 7 days post ICU admission (+13.50 l vs. +6.90 l; P = 0.036) was associated with higher hospital mortality. This association remained significant (OR 95%CI = 1.04 [1.01;1.07] per each l) after adjustment for confounders (age, ascites, infection, lactate, and number of organ failures). Conclusions: FB may be a therapeutic target that helps to improve the outcomes of patients with acute-on-chronic liver failure. This data may inform future clinical trials.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPESousa Cardoso, FPereira, RLaranjo, AGamelas, VBagulho, LGermano, NKarvellas, C2022-12-07T16:14:05Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4309engJ Crit Care. 2021 Jun;63:238-24210.1016/j.jcrc.2020.09.012.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:46:11Zoai:repositorio.chlc.min-saude.pt:10400.17/4309Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:38.205644Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Study |
title |
Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Study |
spellingShingle |
Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Study Sousa Cardoso, F HCC CIR HCC GAS HCC UCI Humans Adult Male Middle Aged Acute-On-Chronic Liver Failure* Cohort Studies Intensive Care Units Prognosis Liver Cirrhosis ROC Curve Organ Dysfunction Scores Retrospective Studies Water-Electrolyte Balance |
title_short |
Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Study |
title_full |
Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Study |
title_fullStr |
Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Study |
title_full_unstemmed |
Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Study |
title_sort |
Positive Fluid Balance Was Associated with Mortality in Patients with Acute-on-Chronic Liver Failure: a Cohort Study |
author |
Sousa Cardoso, F |
author_facet |
Sousa Cardoso, F Pereira, R Laranjo, A Gamelas, V Bagulho, L Germano, N Karvellas, C |
author_role |
author |
author2 |
Pereira, R Laranjo, A Gamelas, V Bagulho, L Germano, N Karvellas, C |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Sousa Cardoso, F Pereira, R Laranjo, A Gamelas, V Bagulho, L Germano, N Karvellas, C |
dc.subject.por.fl_str_mv |
HCC CIR HCC GAS HCC UCI Humans Adult Male Middle Aged Acute-On-Chronic Liver Failure* Cohort Studies Intensive Care Units Prognosis Liver Cirrhosis ROC Curve Organ Dysfunction Scores Retrospective Studies Water-Electrolyte Balance |
topic |
HCC CIR HCC GAS HCC UCI Humans Adult Male Middle Aged Acute-On-Chronic Liver Failure* Cohort Studies Intensive Care Units Prognosis Liver Cirrhosis ROC Curve Organ Dysfunction Scores Retrospective Studies Water-Electrolyte Balance |
description |
Purpose: We aimed to study the effect of FB in the outcomes of critically-ill patients with cirrhosis. Materials: Retrospective analysis of all adult consecutive admissions of patients with cirrhosis and organ failures to the Intensive Care Unit (ICU) at Curry Cabral Hospital (Lisbon, Portugal) and University of Alberta Hospital (Edmonton, Canada) on 08/2013-08/2017. Primary exposure was FB at 3 and 7 days post ICU admission. Primary endpoint was hospital mortality. Results: Amongst 333 patients, median age was 56 years and 67.6% were men. Median MELD, APACHEII, CLIF-SOFA, and CLIF-C-ACLF scores on ICU admission were 27, 28, 14, and 54, respectively. ICU and hospital mortality rates were 33.0% and 49.2%, respectively. While median FB at 3 days post ICU admission (+5.46 l vs. +6.62 l; P = 0.74) was not associated with hospital mortality, higher median FB at 7 days post ICU admission (+13.50 l vs. +6.90 l; P = 0.036) was associated with higher hospital mortality. This association remained significant (OR 95%CI = 1.04 [1.01;1.07] per each l) after adjustment for confounders (age, ascites, infection, lactate, and number of organ failures). Conclusions: FB may be a therapeutic target that helps to improve the outcomes of patients with acute-on-chronic liver failure. This data may inform future clinical trials. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2022-12-07T16:14:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4309 |
url |
http://hdl.handle.net/10400.17/4309 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Crit Care. 2021 Jun;63:238-242 10.1016/j.jcrc.2020.09.012. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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