Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects

Detalhes bibliográficos
Autor(a) principal: Zielinska, Aleksandra
Data de Publicação: 2020
Outros Autores: Alves, Henrique, Marques, Vánia, Durazzo, Alessandra, Lucarini, Massimo, Alves, Thais F., Morsink, Margreet, Willemen, Niels, Eder, Piotr, Chaud, Marco V., Severino, Patricia, Santini, Antonello, Souto, Eliana B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/65835
Resumo: This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.
id RCAP_bf511c3ad8efdc69983a11afb48e9d48
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/65835
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effectscurcuminnanopharmaceuticsnanoparticlescancerhealth propertiesScience & TechnologyThis review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.The authors acknowledge the sponsorship received from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, co-financed by FEDER, under the Partnership Agreement PT2020 for the project UIDB/04469/2020 (strategic fund) granted to E.B.S., the National Council for Scientific and Technological Development (CNPq), Brazil, for the project 425271/2016-1 granted to M.V.C., and the Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES) and Fundação de Ámparo à Pesquisa do Estado de Sergipe (FAPITEC) (88887.159533/2017-00), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 301964/2019-0 Chamada 06/2019, and Chamada CNPq nº 01/2019), and Banco do Nordeste (FUNDECI 2017.0016) granted to P.S. The authors acknowledge the support of the research project: Nutraceutica come supporto nutrizionale nel paziente oncologico, CUP: B83D18000140007.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoZielinska, AleksandraAlves, HenriqueMarques, VániaDurazzo, AlessandraLucarini, MassimoAlves, Thais F.Morsink, MargreetWillemen, NielsEder, PiotrChaud, Marco V.Severino, PatriciaSantini, AntonelloSouto, Eliana B.2020-07-032020-07-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/65835engZielinska, Aleksandra; Alves, Henrique; Marques, Vánia; Durazzo, Alessandra; Lucarini, Massimo; Alves, Thais F.; Morsink, Margreet; Willemen, Niels; Eder, Piotr; Chaud, Marco V.; Severino, Patricia; Santini, Antonello; Souto, Eliana, Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects. Medicina, 56(7), 336, 20201010-660X1648-914410.3390/medicina5607033632635279https://www.mdpi.com/1010-660X/56/7/336info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:21:48Zoai:repositorium.sdum.uminho.pt:1822/65835Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:15:11.043229Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects
title Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects
spellingShingle Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects
Zielinska, Aleksandra
curcumin
nanopharmaceutics
nanoparticles
cancer
health properties
Science & Technology
title_short Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects
title_full Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects
title_fullStr Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects
title_full_unstemmed Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects
title_sort Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects
author Zielinska, Aleksandra
author_facet Zielinska, Aleksandra
Alves, Henrique
Marques, Vánia
Durazzo, Alessandra
Lucarini, Massimo
Alves, Thais F.
Morsink, Margreet
Willemen, Niels
Eder, Piotr
Chaud, Marco V.
Severino, Patricia
Santini, Antonello
Souto, Eliana B.
author_role author
author2 Alves, Henrique
Marques, Vánia
Durazzo, Alessandra
Lucarini, Massimo
Alves, Thais F.
Morsink, Margreet
Willemen, Niels
Eder, Piotr
Chaud, Marco V.
Severino, Patricia
Santini, Antonello
Souto, Eliana B.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Zielinska, Aleksandra
Alves, Henrique
Marques, Vánia
Durazzo, Alessandra
Lucarini, Massimo
Alves, Thais F.
Morsink, Margreet
Willemen, Niels
Eder, Piotr
Chaud, Marco V.
Severino, Patricia
Santini, Antonello
Souto, Eliana B.
dc.subject.por.fl_str_mv curcumin
nanopharmaceutics
nanoparticles
cancer
health properties
Science & Technology
topic curcumin
nanopharmaceutics
nanoparticles
cancer
health properties
Science & Technology
description This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-03
2020-07-03T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/65835
url http://hdl.handle.net/1822/65835
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Zielinska, Aleksandra; Alves, Henrique; Marques, Vánia; Durazzo, Alessandra; Lucarini, Massimo; Alves, Thais F.; Morsink, Margreet; Willemen, Niels; Eder, Piotr; Chaud, Marco V.; Severino, Patricia; Santini, Antonello; Souto, Eliana, Properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects. Medicina, 56(7), 336, 2020
1010-660X
1648-9144
10.3390/medicina56070336
32635279
https://www.mdpi.com/1010-660X/56/7/336
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132597105721344

Registros relacionados