Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker

Detalhes bibliográficos
Autor(a) principal: Martins, Gabriela Ferreira Vasconcelos
Data de Publicação: 2022
Outros Autores: Riveiro, A., Chiussi, S., Sales, M. G. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/75600
Resumo: Available online 13 January 2022
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spelling Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarkerMolecularly-imprinted polymerFlexible substrateGold-based electrodesElectrochemical (bio)sensorOxidative stress biomarkerAvailable online 13 January 2022In recent years, the development of flexible and wearable devices for healthcare and biomedical applications has become an emerging technological goal, particularly with personalized medicine on the rise. As a response to the increasing demand for in-situ sensing platforms that fulfil some essential requirements like sensitivity, reproducibility and high stability, electrochemical sensors have boosted their way for innovative approaches. So, high-quality flexible sensing strategies are still a demand for local monitoring. Herein, a flexible three-electrode system was fabricated on transparent polymeric sheet substrate through physical deposition of gold as working, counter, and reference electrodes. Along the fabrication process, the electrochemical performance of these electrodes was assessed by means of cyclic voltammetry (CV) while gold adherence to the plastic material was continuously improved. Afterwards, a high-performance molecularly-imprinted sensing film inspired by natural recognition mechanism was assembled through electropolymerization of phenol monomer, in the presence of 3-nitrotyrosine (3-NT), directly on the gold surface. Under the optimized conditions, the flexible (bio)sensor platform was able to detect the presence of 3-NT over the concentration range 10 pg/mL 1 g/mL, enabling one of the lower limits of detection found in the literature (1.13 pg/mL or 24.9 pM). The obtained (bio)sensor displayed good reproducibility, stability and selectivity over the chosen interfering substances. Overall, the developed electrochemical device may serve as a flexible, miniaturized, and reliable platform, with potential to be applied in the future as wearable sensing technology.The authors acknowledge the financial support from IBEROS project (Instituto de Bioingeniería en Red para el Envejecimiento Saludable, INTERREG POCTEP/0245_IBEROS_1_E) supported by FEDER, also within the cooperation region of Galicia/Spain and North of Portugal, and the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of PEst UIDB/04469/2020 unit.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoMartins, Gabriela Ferreira VasconcelosRiveiro, A.Chiussi, S.Sales, M. G. F.2022-052022-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/75600engMartins, Gabriela; Riveiro, A.; Chiussi, S.; Sales, M. G. F., Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker. Biosensors and Bioelectronics: X, 10(100107), 20222590-137010.1016/j.biosx.2022.100107100107https://www.sciencedirect.com/journal/biosensors-and-bioelectronics-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:26:13Zoai:repositorium.sdum.uminho.pt:1822/75600Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:20:35.672078Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker
title Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker
spellingShingle Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker
Martins, Gabriela Ferreira Vasconcelos
Molecularly-imprinted polymer
Flexible substrate
Gold-based electrodes
Electrochemical (bio)sensor
Oxidative stress biomarker
title_short Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker
title_full Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker
title_fullStr Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker
title_full_unstemmed Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker
title_sort Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker
author Martins, Gabriela Ferreira Vasconcelos
author_facet Martins, Gabriela Ferreira Vasconcelos
Riveiro, A.
Chiussi, S.
Sales, M. G. F.
author_role author
author2 Riveiro, A.
Chiussi, S.
Sales, M. G. F.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Martins, Gabriela Ferreira Vasconcelos
Riveiro, A.
Chiussi, S.
Sales, M. G. F.
dc.subject.por.fl_str_mv Molecularly-imprinted polymer
Flexible substrate
Gold-based electrodes
Electrochemical (bio)sensor
Oxidative stress biomarker
topic Molecularly-imprinted polymer
Flexible substrate
Gold-based electrodes
Electrochemical (bio)sensor
Oxidative stress biomarker
description Available online 13 January 2022
publishDate 2022
dc.date.none.fl_str_mv 2022-05
2022-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/75600
url https://hdl.handle.net/1822/75600
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Martins, Gabriela; Riveiro, A.; Chiussi, S.; Sales, M. G. F., Flexible sensing devices integrating molecularly-imprinted polymers for the detection of 3-nitrotyrosine biomarker. Biosensors and Bioelectronics: X, 10(100107), 2022
2590-1370
10.1016/j.biosx.2022.100107
100107
https://www.sciencedirect.com/journal/biosensors-and-bioelectronics-x
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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