Sex and suicide : the curious case of Toll-like receptors

Detalhes bibliográficos
Autor(a) principal: Navarro-Costa, Paulo
Data de Publicação: 2020
Outros Autores: Molaro, Antoine, Misra, Chandra Shekhar, Meiklejohn, Colin, Ellis, Peter
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/42969
Resumo: Copyright: © 2020 Navarro-Costa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling Sex and suicide : the curious case of Toll-like receptorsCopyright: © 2020 Navarro-Costa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.During in vitro fertilisation (IVF), pharmacological activation of the murine X chromosome–encoded receptor proteins Toll-like receptor (TLR) 7 and TLR8 reportedly results in male-biased litters by selectively disrupting the motility of X-bearing sperm cells. Thus—in the context of agonist treatment during IVF—these receptors act as ‘suicidal’ segregation distorters that impair their own transmission to the next generation. Such behaviour would, from an evolutionary perspective, be strongly selected against if present during natural fertilisation. Consequently, TLR7/8 biology in vivo must differ significantly from this in vitro situation to allow these genes to persist in the genome. Here, we use our current understanding of male germ cell biology and TLR function as a starting point to explore the mechanistic and evolutionary aspects of this apparent paradox.The following funding sources are acknowledged: PAN-C, Fundação para a Ciência e a Tecnologia (PTDC/MEC-AND/30221/2017); AM, Damon Runyon Cancer Research Foundation (DRG:2192-14) and NIH (R01 GM074108); CSM, Fundação para a Ciência e a Tecnologia doctoral scholarship (PD/BD/114362/2016); CDM, NIH R01-GM123194; and PJE, the UK Higher Education Funding Council for England (HEFCE), the Biotechnology and Biological Sciences Research Council (BBSRC, BB/N000463/1), and the Leverhulme Trust (RPG-2019-414 194). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.PLOSRepositório da Universidade de LisboaNavarro-Costa, PauloMolaro, AntoineMisra, Chandra ShekharMeiklejohn, ColinEllis, Peter2020-04-20T16:59:30Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/42969engPLoS Biol 18 (3), March 23, 20201544-917310.1371/journal.pbio.30006631545-7885info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:43:11Zoai:repositorio.ul.pt:10451/42969Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:55:53.195616Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sex and suicide : the curious case of Toll-like receptors
title Sex and suicide : the curious case of Toll-like receptors
spellingShingle Sex and suicide : the curious case of Toll-like receptors
Navarro-Costa, Paulo
title_short Sex and suicide : the curious case of Toll-like receptors
title_full Sex and suicide : the curious case of Toll-like receptors
title_fullStr Sex and suicide : the curious case of Toll-like receptors
title_full_unstemmed Sex and suicide : the curious case of Toll-like receptors
title_sort Sex and suicide : the curious case of Toll-like receptors
author Navarro-Costa, Paulo
author_facet Navarro-Costa, Paulo
Molaro, Antoine
Misra, Chandra Shekhar
Meiklejohn, Colin
Ellis, Peter
author_role author
author2 Molaro, Antoine
Misra, Chandra Shekhar
Meiklejohn, Colin
Ellis, Peter
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Navarro-Costa, Paulo
Molaro, Antoine
Misra, Chandra Shekhar
Meiklejohn, Colin
Ellis, Peter
description Copyright: © 2020 Navarro-Costa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-20T16:59:30Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/42969
url http://hdl.handle.net/10451/42969
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS Biol 18 (3), March 23, 2020
1544-9173
10.1371/journal.pbio.3000663
1545-7885
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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