Metabolically healthy overweight adolescents : definition and components

Detalhes bibliográficos
Autor(a) principal: Videira-Silva, Antonio
Data de Publicação: 2020
Outros Autores: Freira, Silvia, Fonseca, Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46119
Resumo: © 2020 Annals of Pediatric Endocrinology & Metabolism. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
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spelling Metabolically healthy overweight adolescents : definition and componentsAdolescentsOverweightWeight managementMetabolic healthMetabolic syndrome© 2020 Annals of Pediatric Endocrinology & Metabolism. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly citedPurpose: In adolescents, the definition and clinical implications of metabolically healthy overweight (MHO) status have not been established. This study aimed to investigate the prevalence of MHO according to its most widespread definition, which is based on metabolic syndrome (MS), and to explore further metabolic indicators such as Homeostatic Model Assessment of Insulin Resistance, total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, and C-reactive protein levels, together with metabolic health predictors in a sample of adolescents attending a pediatric obesity clinic. Methods: Data from 487 adolescents categorized as overweight (52.6% females, 88.1% white), with a mean body mass index (BMI) z-score of 2.74 (±1.07 standard deviation [SD]), and a mean age of 14.4 years (±2.2 SD) were cross-sectionally analyzed. From this original sample, a subsample of 176 adolescents underwent a second assessment at 12 (±6 SD) months for longitudinal analysis. Results: From the 487 adolescents originally analyzed, 200 (41.1%) were categorized as MHO, but only 93 (19.1%) had none of the metabolic indicators considered in this study. According to longitudinal analysis, 30 of the 68 adolescents (44%) categorized as MHO at baseline became non-MHO over time. BMI z-score was the best predictor of metabolic health both in cross-sectional and longitudinal analyses. Increased BMI z-score reduced the odds of being categorized as MHO (odds ratio [OR], 0.6; 95% confidence interval [CI], 0.4–0.9; P=.008) and increased the odds of having hypertension (OR 2.1, 95% CI: 1.4–3.3, P=0.001), insulin resistance (OR, 2.4; 95% CI, 1.4–4.1, P=0.001), or a proinflammatory state (OR, 1.2; 95% CI, 1.1–1.3, P=0.002). Conclusion: Diagnosis of MHO should not be exclusively based on MS parameters, and other metabolic indicators should be considered. Adolescents categorized as overweight should participate in weight-management lifestyle interventions regardless of their metabolic health phenotype.AVS is supported by the Portuguese Foundation for Science and Technology (SFRH/BD/130193/2017)Korean Society of Pediatric EndocrinologyRepositório da Universidade de LisboaVideira-Silva, AntonioFreira, SilviaFonseca, Helena2021-02-02T13:21:12Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46119engAnn Pediatr Endocrinol Metab 2020;25:256-2642287-101210.6065/apem.2040052.0262287-1292info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:17Zoai:repositorio.ul.pt:10451/46119Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:23.483433Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Metabolically healthy overweight adolescents : definition and components
title Metabolically healthy overweight adolescents : definition and components
spellingShingle Metabolically healthy overweight adolescents : definition and components
Videira-Silva, Antonio
Adolescents
Overweight
Weight management
Metabolic health
Metabolic syndrome
title_short Metabolically healthy overweight adolescents : definition and components
title_full Metabolically healthy overweight adolescents : definition and components
title_fullStr Metabolically healthy overweight adolescents : definition and components
title_full_unstemmed Metabolically healthy overweight adolescents : definition and components
title_sort Metabolically healthy overweight adolescents : definition and components
author Videira-Silva, Antonio
author_facet Videira-Silva, Antonio
Freira, Silvia
Fonseca, Helena
author_role author
author2 Freira, Silvia
Fonseca, Helena
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Videira-Silva, Antonio
Freira, Silvia
Fonseca, Helena
dc.subject.por.fl_str_mv Adolescents
Overweight
Weight management
Metabolic health
Metabolic syndrome
topic Adolescents
Overweight
Weight management
Metabolic health
Metabolic syndrome
description © 2020 Annals of Pediatric Endocrinology & Metabolism. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-02-02T13:21:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46119
url http://hdl.handle.net/10451/46119
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ann Pediatr Endocrinol Metab 2020;25:256-264
2287-1012
10.6065/apem.2040052.026
2287-1292
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Korean Society of Pediatric Endocrinology
publisher.none.fl_str_mv Korean Society of Pediatric Endocrinology
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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