Serial progression of cortical and medullary thymic epithelial microenvironments.
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10216/114507 |
Resumo: | Thymic epithelial cells (TECs) provide key instructive signals for T-cell differentiation. Thymic cortical (cTECs) and medullary (mTECs) epithelial cells constitute two functionally distinct microenvironments for T-cell development, which derive from a common bipotent TEC progenitor. While seminal studies have partially elucidated events downstream of bipotent TECs in relation to the emergence of mTECs and their progenitors, the control and timing of the emergence of the cTEC lineage, particularly in relation to that of mTEC progenitors, has remained elusive. In this review, we describe distinct models that explain cTEC/mTEC lineage divergence from common bipotent progenitors. In particular, we summarize recent studies in mice providing evidence that mTECs, including the auto-immune regulator(+) subset, derive from progenitors initially endowed with phenotypic properties typically associated with the cTEC lineage. These observations support a novel "serial progression" model of TEC development, in which progenitors serially acquire cTEC lineage markers, prior to their commitment to the mTEC differentiation pathway. Gaining a better understanding of the phenotypic properties of early stages in TEC progenitor development should help in determining the mechanisms regulating cTEC/mTEC lineage development, and in strategies aimed at thymus reconstitution involving TEC therapy. |
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Serial progression of cortical and medullary thymic epithelial microenvironments.AnimalsAutoimmunityCell Communication/immunologyCell DifferentiationCell LineageEpithelial Cells/immunologyHumansImmunotherapy/methodsImmunotherapy/trendsLymphoid Progenitor Cells/immunologyMiceModels, ImmunologicalT-Lymphocyte Subsets/immunologyT-Lymphocytes, Regulatory/immunologyThymus Gland/immunologyThymic epithelial cells (TECs) provide key instructive signals for T-cell differentiation. Thymic cortical (cTECs) and medullary (mTECs) epithelial cells constitute two functionally distinct microenvironments for T-cell development, which derive from a common bipotent TEC progenitor. While seminal studies have partially elucidated events downstream of bipotent TECs in relation to the emergence of mTECs and their progenitors, the control and timing of the emergence of the cTEC lineage, particularly in relation to that of mTEC progenitors, has remained elusive. In this review, we describe distinct models that explain cTEC/mTEC lineage divergence from common bipotent progenitors. In particular, we summarize recent studies in mice providing evidence that mTECs, including the auto-immune regulator(+) subset, derive from progenitors initially endowed with phenotypic properties typically associated with the cTEC lineage. These observations support a novel "serial progression" model of TEC development, in which progenitors serially acquire cTEC lineage markers, prior to their commitment to the mTEC differentiation pathway. Gaining a better understanding of the phenotypic properties of early stages in TEC progenitor development should help in determining the mechanisms regulating cTEC/mTEC lineage development, and in strategies aimed at thymus reconstitution involving TEC therapy.Wiley-VCH Verlag20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/114507eng0014-298010.1002/eji.201344110Alves, NLTakahama, YOhigashi, IRibeiro, ARBaik, SAnderson, GJenkinson, WEinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:53:06Zoai:repositorio-aberto.up.pt:10216/114507Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:28:40.587182Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Serial progression of cortical and medullary thymic epithelial microenvironments. |
title |
Serial progression of cortical and medullary thymic epithelial microenvironments. |
spellingShingle |
Serial progression of cortical and medullary thymic epithelial microenvironments. Alves, NL Animals Autoimmunity Cell Communication/immunology Cell Differentiation Cell Lineage Epithelial Cells/immunology Humans Immunotherapy/methods Immunotherapy/trends Lymphoid Progenitor Cells/immunology Mice Models, Immunological T-Lymphocyte Subsets/immunology T-Lymphocytes, Regulatory/immunology Thymus Gland/immunology |
title_short |
Serial progression of cortical and medullary thymic epithelial microenvironments. |
title_full |
Serial progression of cortical and medullary thymic epithelial microenvironments. |
title_fullStr |
Serial progression of cortical and medullary thymic epithelial microenvironments. |
title_full_unstemmed |
Serial progression of cortical and medullary thymic epithelial microenvironments. |
title_sort |
Serial progression of cortical and medullary thymic epithelial microenvironments. |
author |
Alves, NL |
author_facet |
Alves, NL Takahama, Y Ohigashi, I Ribeiro, AR Baik, S Anderson, G Jenkinson, WE |
author_role |
author |
author2 |
Takahama, Y Ohigashi, I Ribeiro, AR Baik, S Anderson, G Jenkinson, WE |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Alves, NL Takahama, Y Ohigashi, I Ribeiro, AR Baik, S Anderson, G Jenkinson, WE |
dc.subject.por.fl_str_mv |
Animals Autoimmunity Cell Communication/immunology Cell Differentiation Cell Lineage Epithelial Cells/immunology Humans Immunotherapy/methods Immunotherapy/trends Lymphoid Progenitor Cells/immunology Mice Models, Immunological T-Lymphocyte Subsets/immunology T-Lymphocytes, Regulatory/immunology Thymus Gland/immunology |
topic |
Animals Autoimmunity Cell Communication/immunology Cell Differentiation Cell Lineage Epithelial Cells/immunology Humans Immunotherapy/methods Immunotherapy/trends Lymphoid Progenitor Cells/immunology Mice Models, Immunological T-Lymphocyte Subsets/immunology T-Lymphocytes, Regulatory/immunology Thymus Gland/immunology |
description |
Thymic epithelial cells (TECs) provide key instructive signals for T-cell differentiation. Thymic cortical (cTECs) and medullary (mTECs) epithelial cells constitute two functionally distinct microenvironments for T-cell development, which derive from a common bipotent TEC progenitor. While seminal studies have partially elucidated events downstream of bipotent TECs in relation to the emergence of mTECs and their progenitors, the control and timing of the emergence of the cTEC lineage, particularly in relation to that of mTEC progenitors, has remained elusive. In this review, we describe distinct models that explain cTEC/mTEC lineage divergence from common bipotent progenitors. In particular, we summarize recent studies in mice providing evidence that mTECs, including the auto-immune regulator(+) subset, derive from progenitors initially endowed with phenotypic properties typically associated with the cTEC lineage. These observations support a novel "serial progression" model of TEC development, in which progenitors serially acquire cTEC lineage markers, prior to their commitment to the mTEC differentiation pathway. Gaining a better understanding of the phenotypic properties of early stages in TEC progenitor development should help in determining the mechanisms regulating cTEC/mTEC lineage development, and in strategies aimed at thymus reconstitution involving TEC therapy. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10216/114507 |
url |
http://hdl.handle.net/10216/114507 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0014-2980 10.1002/eji.201344110 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley-VCH Verlag |
publisher.none.fl_str_mv |
Wiley-VCH Verlag |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799135593730408448 |