Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections

Detalhes bibliográficos
Autor(a) principal: Albuquerque, A. S.
Data de Publicação: 2007
Outros Autores: Cortesão, C. S., Foxall, R. B., Victorino, R. M., Sousa, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/18296
Resumo: Copyright © 2007 by The American Association of Immunologists, Inc.
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spelling Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infectionsCopyright © 2007 by The American Association of Immunologists, Inc.IL-7 is a nonredundant cytokine for T cell homeostasis. Circulating IL-7 levels increase in lymphopenic clinical settings, including HIV-1 infection. HIV-2 infection is considered a “natural” model of attenuated HIV disease given its much slower rate of CD4 decline than HIV-1 and limited impact on the survival of the majority of infected adults. We compared untreated HIV-1- and HIV-2-infected patients and found that the HIV-2 cohort demonstrated a delayed increase in IL-7 levels during the progressive depletion of circulating CD4 T cells as well as a dissociation between the acquisition of markers of T cell effector differentiation and the loss of IL-7Rα expression. This comparison of two persistent infections associated with progressive CD4 depletion and immune activation demonstrates that a better prognosis is not necessarily associated with higher levels of IL-7. Moreover, the delayed increase in IL-7 coupled with sustained expression of IL-7Rα suggests a maximization of available resources in HIV-2. The observation that increased IL-7 levels early in HIV-1 infection were unable to reduce the rate of CD4 loss and the impaired expression of the IL-7Rα irrespective of the state of cell differentiation raises concerns regarding the use of IL-7 therapy in HIV-1 infection.This work was supported by a grant from Fundação para a Ciência e a Tecnologia and by Programa Operacional Ciência e Inovação 2010 Grant POCI2010 (to A.E.S.). A.S.A., C.S.C., R.B.F., and R.S.S. received scholarships from the Fundação para a Ciência e a Technologia.American Association of ImmunologistsRepositório da Universidade de LisboaAlbuquerque, A. S.Cortesão, C. S.Foxall, R. B.Victorino, R. M.Sousa, A. E.2015-06-17T11:05:39Z20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/18296engJ Immunol 2007; 178:3252-32590022-1767http://www.jimmunol.org/content/178/5/3252.longmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:04:31Zoai:repositorio.ul.pt:10451/18296Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:53.974757Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections
title Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections
spellingShingle Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections
Albuquerque, A. S.
title_short Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections
title_full Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections
title_fullStr Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections
title_full_unstemmed Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections
title_sort Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections
author Albuquerque, A. S.
author_facet Albuquerque, A. S.
Cortesão, C. S.
Foxall, R. B.
Victorino, R. M.
Sousa, A. E.
author_role author
author2 Cortesão, C. S.
Foxall, R. B.
Victorino, R. M.
Sousa, A. E.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Albuquerque, A. S.
Cortesão, C. S.
Foxall, R. B.
Victorino, R. M.
Sousa, A. E.
description Copyright © 2007 by The American Association of Immunologists, Inc.
publishDate 2007
dc.date.none.fl_str_mv 2007
2007-01-01T00:00:00Z
2015-06-17T11:05:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/18296
url http://hdl.handle.net/10451/18296
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Immunol 2007; 178:3252-3259
0022-1767
http://www.jimmunol.org/content/178/5/3252.long
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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