Renal morphophysiological changes in Wistar rats with malnutrition intra uterine.
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/506 |
Resumo: | Many epidemiological studies suggest that the intra uterine environment is extremely important in determining the future of individual health. Changes in maternal nutritional status, reflected in birth weight may program the offspring to the development of diseases in adulthood. Studies with animals exposed to intrauterine malnutrition have suggested a reduction in the number of clusters in addition to increased blood pressure.To review the literature morphophysiology changes in the kidney of adult Wistar rats exposed to malnutrition during intrauterine life.We performed a search in the following databases: PubMed, MEDLINE, SCIENCE DIRECT, LILACS. The main search terms were malnutrition and renal function in Portuguese and English. We included original articles involving albino rats. We excluded review articles as well as those involving humans.According to Franco et al (2009) renal function and the number of glomeruli reduced by poor on intrauterine development, predisposing offspring to kidney disease in adulthood. According to Chen (2009) ultra-glomerular structure is not affected by maternal malnutrition suggesting that this factor does not contribute to the pathogenesis of hypertension after maternal malnutrition. Viana-son et al (2009) believes that stress on placents, causes disruption on sodium pumps in the proximal tubules of the kidney, resulting hypertension.The intrauterine malnutrition appears to interfere with the programming of kidney function with changes in glomerular morphophysiology, however, its mechanisms remain uncertain. We suggest further studies of the type and randomized clinical trials aimed at understanding the factors that trigger this process. |
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Renal morphophysiological changes in Wistar rats with malnutrition intra uterine.Alterações morfofisiológicas renais em ratos wistar submetidos à má-nutrição intrauterina.Many epidemiological studies suggest that the intra uterine environment is extremely important in determining the future of individual health. Changes in maternal nutritional status, reflected in birth weight may program the offspring to the development of diseases in adulthood. Studies with animals exposed to intrauterine malnutrition have suggested a reduction in the number of clusters in addition to increased blood pressure.To review the literature morphophysiology changes in the kidney of adult Wistar rats exposed to malnutrition during intrauterine life.We performed a search in the following databases: PubMed, MEDLINE, SCIENCE DIRECT, LILACS. The main search terms were malnutrition and renal function in Portuguese and English. We included original articles involving albino rats. We excluded review articles as well as those involving humans.According to Franco et al (2009) renal function and the number of glomeruli reduced by poor on intrauterine development, predisposing offspring to kidney disease in adulthood. According to Chen (2009) ultra-glomerular structure is not affected by maternal malnutrition suggesting that this factor does not contribute to the pathogenesis of hypertension after maternal malnutrition. Viana-son et al (2009) believes that stress on placents, causes disruption on sodium pumps in the proximal tubules of the kidney, resulting hypertension.The intrauterine malnutrition appears to interfere with the programming of kidney function with changes in glomerular morphophysiology, however, its mechanisms remain uncertain. We suggest further studies of the type and randomized clinical trials aimed at understanding the factors that trigger this process.Many epidemiological studies suggest that the intra uterine environment is extremely important in determining the future of individual health. Changes in maternal nutritional status, reflected in birth weight may program the offspring to the development of diseases in adulthood. Studies with animals exposed to intrauterine malnutrition have suggested a reduction in the number of clusters in addition to increased blood pressure.To review the literature morphophysiology changes in the kidney of adult Wistar rats exposed to malnutrition during intrauterine life.We performed a search in the following databases: PubMed, MEDLINE, SCIENCE DIRECT, LILACS. The main search terms were malnutrition and renal function in Portuguese and English. We included original articles involving albino rats. We excluded review articles as well as those involving humans.According to Franco et al (2009) renal function and the number of glomeruli reduced by poor on intrauterine development, predisposing offspring to kidney disease in adulthood. According to Chen (2009) ultra-glomerular structure is not affected by maternal malnutrition suggesting that this factor does not contribute to the pathogenesis of hypertension after maternal malnutrition. Viana-son et al (2009) believes that stress on placents, causes disruption on sodium pumps in the proximal tubules of the kidney, resulting hypertension.The intrauterine malnutrition appears to interfere with the programming of kidney function with changes in glomerular morphophysiology, however, its mechanisms remain uncertain. We suggest further studies of the type and randomized clinical trials aimed at understanding the factors that trigger this process.Ordem dos Médicos2011-12-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/506oai:ojs.www.actamedicaportuguesa.com:article/506Acta Médica Portuguesa; Vol. 24 No. 5 (2011): Setembro-Outubro; 799-804Acta Médica Portuguesa; Vol. 24 N.º 5 (2011): Setembro-Outubro; 799-8041646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/506https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/506/214Assis, Thiago de OliveiraAlves Fidelis, Thiago Andréinfo:eu-repo/semantics/openAccess2022-12-20T10:56:25Zoai:ojs.www.actamedicaportuguesa.com:article/506Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:16:32.774784Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Renal morphophysiological changes in Wistar rats with malnutrition intra uterine. Alterações morfofisiológicas renais em ratos wistar submetidos à má-nutrição intrauterina. |
title |
Renal morphophysiological changes in Wistar rats with malnutrition intra uterine. |
spellingShingle |
Renal morphophysiological changes in Wistar rats with malnutrition intra uterine. Assis, Thiago de Oliveira |
title_short |
Renal morphophysiological changes in Wistar rats with malnutrition intra uterine. |
title_full |
Renal morphophysiological changes in Wistar rats with malnutrition intra uterine. |
title_fullStr |
Renal morphophysiological changes in Wistar rats with malnutrition intra uterine. |
title_full_unstemmed |
Renal morphophysiological changes in Wistar rats with malnutrition intra uterine. |
title_sort |
Renal morphophysiological changes in Wistar rats with malnutrition intra uterine. |
author |
Assis, Thiago de Oliveira |
author_facet |
Assis, Thiago de Oliveira Alves Fidelis, Thiago André |
author_role |
author |
author2 |
Alves Fidelis, Thiago André |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Assis, Thiago de Oliveira Alves Fidelis, Thiago André |
description |
Many epidemiological studies suggest that the intra uterine environment is extremely important in determining the future of individual health. Changes in maternal nutritional status, reflected in birth weight may program the offspring to the development of diseases in adulthood. Studies with animals exposed to intrauterine malnutrition have suggested a reduction in the number of clusters in addition to increased blood pressure.To review the literature morphophysiology changes in the kidney of adult Wistar rats exposed to malnutrition during intrauterine life.We performed a search in the following databases: PubMed, MEDLINE, SCIENCE DIRECT, LILACS. The main search terms were malnutrition and renal function in Portuguese and English. We included original articles involving albino rats. We excluded review articles as well as those involving humans.According to Franco et al (2009) renal function and the number of glomeruli reduced by poor on intrauterine development, predisposing offspring to kidney disease in adulthood. According to Chen (2009) ultra-glomerular structure is not affected by maternal malnutrition suggesting that this factor does not contribute to the pathogenesis of hypertension after maternal malnutrition. Viana-son et al (2009) believes that stress on placents, causes disruption on sodium pumps in the proximal tubules of the kidney, resulting hypertension.The intrauterine malnutrition appears to interfere with the programming of kidney function with changes in glomerular morphophysiology, however, its mechanisms remain uncertain. We suggest further studies of the type and randomized clinical trials aimed at understanding the factors that trigger this process. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-29 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/506 oai:ojs.www.actamedicaportuguesa.com:article/506 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/506 |
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oai:ojs.www.actamedicaportuguesa.com:article/506 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/506 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/506/214 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 24 No. 5 (2011): Setembro-Outubro; 799-804 Acta Médica Portuguesa; Vol. 24 N.º 5 (2011): Setembro-Outubro; 799-804 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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