Intermediary metabolism: An intricate network at the crossroads of cell fate and function
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/94387 https://doi.org/10.1016/j.bbadis.2020.165887 |
Resumo: | Intermediary metabolism is traditionally viewed as the large, highly integrated network of reactions that provides cells with metabolic energy, reducing power and biosynthetic intermediates. The elucidation of its major pathways and molecular mechanisms of energy transduction occupied some of the brightest scientific minds for almost two centuries. When these goals were achieved, a sense that intermediary metabolism was mostly a solved problem pervaded the broader biochemical community, and the field lost its vitality. However, intermediary metabolism has recently been re-energized by several paradigm-shifting discoveries that challenged its perception as a self-contained system and re-positioned it at the crossroads of all aspects of cell function, from cell growth, proliferation and death to epigenetics and immunity. Emphasis is now increasingly placed on the involvement of metabolic dysfunction in human disease. In this review, we will navigate from the dawn of intermediary metabolism research to present day work on this ever-expanding field. |
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Intermediary metabolism: An intricate network at the crossroads of cell fate and functionMetabolismHistorical perspectiveMetabolic regulationEpigeneticsApoptosisImmunometabolismIntermediary metabolism is traditionally viewed as the large, highly integrated network of reactions that provides cells with metabolic energy, reducing power and biosynthetic intermediates. The elucidation of its major pathways and molecular mechanisms of energy transduction occupied some of the brightest scientific minds for almost two centuries. When these goals were achieved, a sense that intermediary metabolism was mostly a solved problem pervaded the broader biochemical community, and the field lost its vitality. However, intermediary metabolism has recently been re-energized by several paradigm-shifting discoveries that challenged its perception as a self-contained system and re-positioned it at the crossroads of all aspects of cell function, from cell growth, proliferation and death to epigenetics and immunity. Emphasis is now increasingly placed on the involvement of metabolic dysfunction in human disease. In this review, we will navigate from the dawn of intermediary metabolism research to present day work on this ever-expanding field.Associação de Apoio ao Centro de Investigação em Meio Ambiente, Genética e Oncobiologia (ACIMAGO, grant 16/12). L.M.R.F. is the Jeffrey G. Klein Family Diabetes Fellow at the University of California, San Francisco. A.M.L. was supported by an NIH T32 Training Grant (CA009302-40).D31F-2F85-32BE | Margarida Conceição Moreira Sobralinfo:eu-repo/semantics/publishedVersionElsevier2020-06-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/94387http://hdl.handle.net/10316/94387https://doi.org/10.1016/j.bbadis.2020.165887eng0925-4439cv-prod-1499356https://www.sciencedirect.com/science/article/pii/S0925443920302350Leonardo M. R. Ferreira, Leonardo M. R.Li, Albert M.Serafim, Teresa L.Sobral, Margarida C.Alpoim, Maria CarmenUrbano, Ana M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-10-26T12:36:08Zoai:estudogeral.uc.pt:10316/94387Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:13:05.011440Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Intermediary metabolism: An intricate network at the crossroads of cell fate and function |
title |
Intermediary metabolism: An intricate network at the crossroads of cell fate and function |
spellingShingle |
Intermediary metabolism: An intricate network at the crossroads of cell fate and function Leonardo M. R. Ferreira, Leonardo M. R. Metabolism Historical perspective Metabolic regulation Epigenetics Apoptosis Immunometabolism |
title_short |
Intermediary metabolism: An intricate network at the crossroads of cell fate and function |
title_full |
Intermediary metabolism: An intricate network at the crossroads of cell fate and function |
title_fullStr |
Intermediary metabolism: An intricate network at the crossroads of cell fate and function |
title_full_unstemmed |
Intermediary metabolism: An intricate network at the crossroads of cell fate and function |
title_sort |
Intermediary metabolism: An intricate network at the crossroads of cell fate and function |
author |
Leonardo M. R. Ferreira, Leonardo M. R. |
author_facet |
Leonardo M. R. Ferreira, Leonardo M. R. Li, Albert M. Serafim, Teresa L. Sobral, Margarida C. Alpoim, Maria Carmen Urbano, Ana M. |
author_role |
author |
author2 |
Li, Albert M. Serafim, Teresa L. Sobral, Margarida C. Alpoim, Maria Carmen Urbano, Ana M. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Leonardo M. R. Ferreira, Leonardo M. R. Li, Albert M. Serafim, Teresa L. Sobral, Margarida C. Alpoim, Maria Carmen Urbano, Ana M. |
dc.subject.por.fl_str_mv |
Metabolism Historical perspective Metabolic regulation Epigenetics Apoptosis Immunometabolism |
topic |
Metabolism Historical perspective Metabolic regulation Epigenetics Apoptosis Immunometabolism |
description |
Intermediary metabolism is traditionally viewed as the large, highly integrated network of reactions that provides cells with metabolic energy, reducing power and biosynthetic intermediates. The elucidation of its major pathways and molecular mechanisms of energy transduction occupied some of the brightest scientific minds for almost two centuries. When these goals were achieved, a sense that intermediary metabolism was mostly a solved problem pervaded the broader biochemical community, and the field lost its vitality. However, intermediary metabolism has recently been re-energized by several paradigm-shifting discoveries that challenged its perception as a self-contained system and re-positioned it at the crossroads of all aspects of cell function, from cell growth, proliferation and death to epigenetics and immunity. Emphasis is now increasingly placed on the involvement of metabolic dysfunction in human disease. In this review, we will navigate from the dawn of intermediary metabolism research to present day work on this ever-expanding field. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/94387 http://hdl.handle.net/10316/94387 https://doi.org/10.1016/j.bbadis.2020.165887 |
url |
http://hdl.handle.net/10316/94387 https://doi.org/10.1016/j.bbadis.2020.165887 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0925-4439 cv-prod-1499356 https://www.sciencedirect.com/science/article/pii/S0925443920302350 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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