Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/8550 |
Resumo: | The early diagnosis of and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 is crucial in preventing possible irreversible neurologic damage, megaloblastic anemia, and failure to thrive. We assess the usefulness of the early detection of asymptomatic B12 deficiency related to acquired conditions and highlight the importance of monitoring serum vitamin B12 levels during pregnancy. We describe demographic, clinical, dietary, and biochemical data, including the evolution of a vitamin B12 deficiency's functional biomarkers. We enrolled 12 newborns (5 males) with an age range of 1-2 months old that were exclusively breastfed and asymptomatic. These cases were referred to our metabolic unit due to alterations in expanded newborn screening: high levels of methylmalonic acid and/or total homocysteine (tHcy). All mothers were under a vegetarian diet except three who had abnormal B12 absorption, and all presented low or borderline serum B12 level and high plasma levels of tHcy. Supplementation with oral vitB12 re-established the metabolic homeostasis of the mothers. In infants, therapy with an intramuscular injection of 1.0 mg hydroxocobalamin led to the rapid normalization of the metabolic pattern, and a healthy outcome was observed. Acquired B12 deficiency should be ruled out before proceeding in a differential diagnosis of cobalamin metabolism deficits, methylmalonic acidemia, and homocystinuria. |
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Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early DetectionMethylmalonic AcidNewborn ScreeningPregnancyTotal HomocysteineVitamin B12 DeficiencyDoenças GenéticasThe early diagnosis of and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 is crucial in preventing possible irreversible neurologic damage, megaloblastic anemia, and failure to thrive. We assess the usefulness of the early detection of asymptomatic B12 deficiency related to acquired conditions and highlight the importance of monitoring serum vitamin B12 levels during pregnancy. We describe demographic, clinical, dietary, and biochemical data, including the evolution of a vitamin B12 deficiency's functional biomarkers. We enrolled 12 newborns (5 males) with an age range of 1-2 months old that were exclusively breastfed and asymptomatic. These cases were referred to our metabolic unit due to alterations in expanded newborn screening: high levels of methylmalonic acid and/or total homocysteine (tHcy). All mothers were under a vegetarian diet except three who had abnormal B12 absorption, and all presented low or borderline serum B12 level and high plasma levels of tHcy. Supplementation with oral vitB12 re-established the metabolic homeostasis of the mothers. In infants, therapy with an intramuscular injection of 1.0 mg hydroxocobalamin led to the rapid normalization of the metabolic pattern, and a healthy outcome was observed. Acquired B12 deficiency should be ruled out before proceeding in a differential diagnosis of cobalamin metabolism deficits, methylmalonic acidemia, and homocystinuria.MDPIRepositório Científico do Instituto Nacional de SaúdeLipari Pinto, PatríciaFlorindo, CristinaJaneiro, PatríciaSantos, Rita LoureiroMexia, SandraRocha, HugoTavares de Almeida, IsabelVilarinho, LauraGaspar, Ana2023-03-08T15:14:55Z2022-10-202022-10-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8550engNutrients. 2022 Oct 20;14(20):4397. doi: 10.3390/nu14204397.2072-664310.3390/nu14204397info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:38Zoai:repositorio.insa.pt:10400.18/8550Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:11.423481Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title |
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
spellingShingle |
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection Lipari Pinto, Patrícia Methylmalonic Acid Newborn Screening Pregnancy Total Homocysteine Vitamin B12 Deficiency Doenças Genéticas |
title_short |
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title_full |
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title_fullStr |
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title_full_unstemmed |
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
title_sort |
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection |
author |
Lipari Pinto, Patrícia |
author_facet |
Lipari Pinto, Patrícia Florindo, Cristina Janeiro, Patrícia Santos, Rita Loureiro Mexia, Sandra Rocha, Hugo Tavares de Almeida, Isabel Vilarinho, Laura Gaspar, Ana |
author_role |
author |
author2 |
Florindo, Cristina Janeiro, Patrícia Santos, Rita Loureiro Mexia, Sandra Rocha, Hugo Tavares de Almeida, Isabel Vilarinho, Laura Gaspar, Ana |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Lipari Pinto, Patrícia Florindo, Cristina Janeiro, Patrícia Santos, Rita Loureiro Mexia, Sandra Rocha, Hugo Tavares de Almeida, Isabel Vilarinho, Laura Gaspar, Ana |
dc.subject.por.fl_str_mv |
Methylmalonic Acid Newborn Screening Pregnancy Total Homocysteine Vitamin B12 Deficiency Doenças Genéticas |
topic |
Methylmalonic Acid Newborn Screening Pregnancy Total Homocysteine Vitamin B12 Deficiency Doenças Genéticas |
description |
The early diagnosis of and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 is crucial in preventing possible irreversible neurologic damage, megaloblastic anemia, and failure to thrive. We assess the usefulness of the early detection of asymptomatic B12 deficiency related to acquired conditions and highlight the importance of monitoring serum vitamin B12 levels during pregnancy. We describe demographic, clinical, dietary, and biochemical data, including the evolution of a vitamin B12 deficiency's functional biomarkers. We enrolled 12 newborns (5 males) with an age range of 1-2 months old that were exclusively breastfed and asymptomatic. These cases were referred to our metabolic unit due to alterations in expanded newborn screening: high levels of methylmalonic acid and/or total homocysteine (tHcy). All mothers were under a vegetarian diet except three who had abnormal B12 absorption, and all presented low or borderline serum B12 level and high plasma levels of tHcy. Supplementation with oral vitB12 re-established the metabolic homeostasis of the mothers. In infants, therapy with an intramuscular injection of 1.0 mg hydroxocobalamin led to the rapid normalization of the metabolic pattern, and a healthy outcome was observed. Acquired B12 deficiency should be ruled out before proceeding in a differential diagnosis of cobalamin metabolism deficits, methylmalonic acidemia, and homocystinuria. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-20 2022-10-20T00:00:00Z 2023-03-08T15:14:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8550 |
url |
http://hdl.handle.net/10400.18/8550 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nutrients. 2022 Oct 20;14(20):4397. doi: 10.3390/nu14204397. 2072-6643 10.3390/nu14204397 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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