Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors

Detalhes bibliográficos
Autor(a) principal: Leitão, Ana Lúcia
Data de Publicação: 2021
Outros Autores: Enguita, Francisco J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46931
Resumo: Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
id RCAP_c8a16d6c8e3325b67d07f9f9ea2240bb
oai_identifier_str oai:repositorio.ul.pt:10451/46931
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighborsPolyesterEsterasePlastic polymerBiodegradationdepolymerizing esterasePETaseCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Esters are organic compounds widely represented in cellular structures and metabolism, originated by the condensation of organic acids and alcohols. Esterification reactions are also used by chemical industries for the production of synthetic plastic polymers. Polyester plastics are an increasing source of environmental pollution due to their intrinsic stability and limited recycling efforts. Bioremediation of polyesters based on the use of specific microbial enzymes is an interesting alternative to the current methods for the valorization of used plastics. Microbial esterases are promising catalysts for the biodegradation of polyesters that can be engineered to improve their biochemical properties. In this work, we analyzed the structure-activity relationships in microbial esterases, with special focus on the recently described plastic-degrading enzymes isolated from marine microorganisms and their structural homologs. Our analysis, based on structure-alignment, molecular docking, coevolution of amino acids and surface electrostatics determined the specific characteristics of some polyester hydrolases that could be related with their efficiency in the degradation of aromatic polyesters, such as phthalates.This work is supported by the Portuguese Foundation for Science and Technology (FCT) under the framework of the research grant PTDC-MED-GEN-29389-2017.MDPIRepositório da Universidade de LisboaLeitão, Ana LúciaEnguita, Francisco J.2021-03-19T16:27:00Z2021-02-262021-02-26T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46931engInt. J. Mol. Sci. 2021, 22, 2332.1661-659610.3390/ijms220523321422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:30Zoai:repositorio.ul.pt:10451/46931Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:00.457750Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
title Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
spellingShingle Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
Leitão, Ana Lúcia
Polyester
Esterase
Plastic polymer
Biodegradation
depolymerizing esterase
PETase
title_short Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
title_full Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
title_fullStr Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
title_full_unstemmed Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
title_sort Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors
author Leitão, Ana Lúcia
author_facet Leitão, Ana Lúcia
Enguita, Francisco J.
author_role author
author2 Enguita, Francisco J.
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Leitão, Ana Lúcia
Enguita, Francisco J.
dc.subject.por.fl_str_mv Polyester
Esterase
Plastic polymer
Biodegradation
depolymerizing esterase
PETase
topic Polyester
Esterase
Plastic polymer
Biodegradation
depolymerizing esterase
PETase
description Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-03-19T16:27:00Z
2021-02-26
2021-02-26T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46931
url http://hdl.handle.net/10451/46931
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int. J. Mol. Sci. 2021, 22, 2332.
1661-6596
10.3390/ijms22052332
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134535766507520

Registros relacionados