Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years

Detalhes bibliográficos
Autor(a) principal: Stal, Rosalinde
Data de Publicação: 2022
Outros Autores: Sepriano, Alexandre, van Gaalen, Floris Alexander, Baraliakos, Xenofon, van den Berg, Rosaline, Reijnierse, Monique, Braun, Juergen, Landewé, Robert B M, van der Heijde, Désirée
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/135841
Resumo: © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.
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spelling Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 yearsradiographic axial spondyloarthritissyndesmophytesfacet jointsankylosislow dose CT© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.OBJECTIVES: In radiographic axial spondyloarthritis (r-axSpA), spinal damage manifests as syndesmophytes and facet joint ankylosis (FJA). We evaluated whether the presence of one lesion increased the risk of the other lesion. METHODS: Patients with r-axSpA underwent low-dose CT (ldCT) and MRI of the whole spine at baseline and two years. On ldCT, vertebrae were scored for presence and size of syndesmophytes; facet joints were assessed for ankylosis. MR images were assessed for inflammation. Two hypotheses were tested: 1) presence of FJA is associated with new syndesmophyte(s) on the same vertebral unit (VU) two years later, and 2) presence of bridging syndesmophyte(s) is associated with new FJA on the same VU two years later. Two Generalized Estimating Equations models were tested per hypothesis using increase of FJA/syndesmophytes (model A) or presence of FJA/syndesmophytes (model B) as outcome, adjusted for inflammation at baseline. Secondary analyses tested the hypotheses with outcomes on adjacent VUs and dose-response effects. RESULTS: Fifty-one patients were included (mean age 49, 84% male, 82% HLA-B27+). Baseline bridging syndesmophytes occurred more often (range: 10-60% per VU) than FJA (range: 8-36%). ORs(95%CI) for presence of bridging syndesmophytes on development of FJA were 3.55(2.03-6.21) for model A and 3.30(2.14-5.09) for model B. ORs for presence of baseline FJA on new syndesmophytes were 1.87(1.20-2.92) for model A and 1.69(0.88-3.22) for model B. Secondary analyses yielded positive ORs for both hypotheses. CONCLUSIONS: Bone formation in vertebrae and in facet joints influence each other's occurrence, with the effect of syndesmophytes being larger than that of FJA.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNStal, RosalindeSepriano, Alexandrevan Gaalen, Floris AlexanderBaraliakos, Xenofonvan den Berg, RosalineReijnierse, MoniqueBraun, JuergenLandewé, Robert B Mvan der Heijde, Désirée2022-04-04T22:38:22Z2022-122022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/135841eng1462-0324PURE: 42509194https://doi.org/10.1093/rheumatology/keac176info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:14:07Zoai:run.unl.pt:10362/135841Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:31.059049Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years
title Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years
spellingShingle Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years
Stal, Rosalinde
radiographic axial spondyloarthritis
syndesmophytes
facet joints
ankylosis
low dose CT
title_short Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years
title_full Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years
title_fullStr Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years
title_full_unstemmed Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years
title_sort Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years
author Stal, Rosalinde
author_facet Stal, Rosalinde
Sepriano, Alexandre
van Gaalen, Floris Alexander
Baraliakos, Xenofon
van den Berg, Rosaline
Reijnierse, Monique
Braun, Juergen
Landewé, Robert B M
van der Heijde, Désirée
author_role author
author2 Sepriano, Alexandre
van Gaalen, Floris Alexander
Baraliakos, Xenofon
van den Berg, Rosaline
Reijnierse, Monique
Braun, Juergen
Landewé, Robert B M
van der Heijde, Désirée
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Stal, Rosalinde
Sepriano, Alexandre
van Gaalen, Floris Alexander
Baraliakos, Xenofon
van den Berg, Rosaline
Reijnierse, Monique
Braun, Juergen
Landewé, Robert B M
van der Heijde, Désirée
dc.subject.por.fl_str_mv radiographic axial spondyloarthritis
syndesmophytes
facet joints
ankylosis
low dose CT
topic radiographic axial spondyloarthritis
syndesmophytes
facet joints
ankylosis
low dose CT
description © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-04T22:38:22Z
2022-12
2022-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/135841
url http://hdl.handle.net/10362/135841
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1462-0324
PURE: 42509194
https://doi.org/10.1093/rheumatology/keac176
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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