Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/135841 |
Resumo: | © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 yearsradiographic axial spondyloarthritissyndesmophytesfacet jointsankylosislow dose CT© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.OBJECTIVES: In radiographic axial spondyloarthritis (r-axSpA), spinal damage manifests as syndesmophytes and facet joint ankylosis (FJA). We evaluated whether the presence of one lesion increased the risk of the other lesion. METHODS: Patients with r-axSpA underwent low-dose CT (ldCT) and MRI of the whole spine at baseline and two years. On ldCT, vertebrae were scored for presence and size of syndesmophytes; facet joints were assessed for ankylosis. MR images were assessed for inflammation. Two hypotheses were tested: 1) presence of FJA is associated with new syndesmophyte(s) on the same vertebral unit (VU) two years later, and 2) presence of bridging syndesmophyte(s) is associated with new FJA on the same VU two years later. Two Generalized Estimating Equations models were tested per hypothesis using increase of FJA/syndesmophytes (model A) or presence of FJA/syndesmophytes (model B) as outcome, adjusted for inflammation at baseline. Secondary analyses tested the hypotheses with outcomes on adjacent VUs and dose-response effects. RESULTS: Fifty-one patients were included (mean age 49, 84% male, 82% HLA-B27+). Baseline bridging syndesmophytes occurred more often (range: 10-60% per VU) than FJA (range: 8-36%). ORs(95%CI) for presence of bridging syndesmophytes on development of FJA were 3.55(2.03-6.21) for model A and 3.30(2.14-5.09) for model B. ORs for presence of baseline FJA on new syndesmophytes were 1.87(1.20-2.92) for model A and 1.69(0.88-3.22) for model B. Secondary analyses yielded positive ORs for both hypotheses. CONCLUSIONS: Bone formation in vertebrae and in facet joints influence each other's occurrence, with the effect of syndesmophytes being larger than that of FJA.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNStal, RosalindeSepriano, Alexandrevan Gaalen, Floris AlexanderBaraliakos, Xenofonvan den Berg, RosalineReijnierse, MoniqueBraun, JuergenLandewé, Robert B Mvan der Heijde, Désirée2022-04-04T22:38:22Z2022-122022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/135841eng1462-0324PURE: 42509194https://doi.org/10.1093/rheumatology/keac176info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:14:07Zoai:run.unl.pt:10362/135841Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:31.059049Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years |
title |
Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years |
spellingShingle |
Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years Stal, Rosalinde radiographic axial spondyloarthritis syndesmophytes facet joints ankylosis low dose CT |
title_short |
Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years |
title_full |
Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years |
title_fullStr |
Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years |
title_full_unstemmed |
Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years |
title_sort |
Associations between syndesmophytes and facet joint ankylosis in radiographic axial spondyloarthritis patients on low-dose CT over 2 years |
author |
Stal, Rosalinde |
author_facet |
Stal, Rosalinde Sepriano, Alexandre van Gaalen, Floris Alexander Baraliakos, Xenofon van den Berg, Rosaline Reijnierse, Monique Braun, Juergen Landewé, Robert B M van der Heijde, Désirée |
author_role |
author |
author2 |
Sepriano, Alexandre van Gaalen, Floris Alexander Baraliakos, Xenofon van den Berg, Rosaline Reijnierse, Monique Braun, Juergen Landewé, Robert B M van der Heijde, Désirée |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Stal, Rosalinde Sepriano, Alexandre van Gaalen, Floris Alexander Baraliakos, Xenofon van den Berg, Rosaline Reijnierse, Monique Braun, Juergen Landewé, Robert B M van der Heijde, Désirée |
dc.subject.por.fl_str_mv |
radiographic axial spondyloarthritis syndesmophytes facet joints ankylosis low dose CT |
topic |
radiographic axial spondyloarthritis syndesmophytes facet joints ankylosis low dose CT |
description |
© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-04T22:38:22Z 2022-12 2022-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/135841 |
url |
http://hdl.handle.net/10362/135841 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1462-0324 PURE: 42509194 https://doi.org/10.1093/rheumatology/keac176 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138086222823425 |