Multi-material implants for temporomandibular joint disc repair : tailored additive manufacturing production

Detalhes bibliográficos
Autor(a) principal: Moura, Carla
Data de Publicação: 2020
Outros Autores: Trindade, Daniela, Vieira, Milena, Francisco, Luís, Ângelo, David, Alves, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47368
Resumo: Copyright © 2020 Moura, Trindade, Vieira, Francisco, Ângelo and Alves. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Multi-material implants for temporomandibular joint disc repair : tailored additive manufacturing productionTemporomandibular joint discProcessing conditionsPoly(ε-caprolactone)Poly(ethylene glycol) diacrylatemulti-material structuresCopyright © 2020 Moura, Trindade, Vieira, Francisco, Ângelo and Alves. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Temporomandibular disorders (TMD) affect a substantial percentage of the population, and the resources spent on their treatment are considerable. Despite the worldwide efforts around Tissue Engineering of the temporomandibular joint (TMJ) disc, a proper implant offering a long-term solution for TMD was not yet developed. To contribute to these efforts, this work is focused on the research and development of implants for TMJ disc regeneration. Scaffolds and hydrogels mimicking the TMJ disc of black Merino sheep were produced using different materials, poly(ε-caprolactone) (PCL) and poly(ethylene glycol) diacrylate (PEGDA), and as a multi-material structure. Different parameters of the scaffold manufacturing were assessed: the influence of processing temperatures, filament diameter, and biological environment. Moreover, two multi-material approaches were also assessed, scaffold with a hydrogel shell and scaffold with a hydrogel core. It was found that increasing temperature, the scaffolds' porosity decreases, increasing their compressive modulus. Decreasing the filament size (300 to 200 μm) decreases the compressive modulus to almost half of the initial value. Scaffolds with 200 μm filaments are the ones with a closer modulus to the native disc and their properties are maintained under hydrated conditions. The introduction of a hydrogel core in these scaffolds presented better mechanical properties to TMJ disc substitution.This work was supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro 2020 through the Project references: UID/Multi/04044/2019; PAMI – ROTEIRO/0328/2013 (No. 022158), MATIS (CENTRO-01-0145-FEDER-000014 – 3362), and BIODISCUS (CENTRO-01-0247-FEDER-039969).Frontiers MediaRepositório da Universidade de LisboaMoura, CarlaTrindade, DanielaVieira, MilenaFrancisco, LuísÂngelo, DavidAlves, Nuno2021-04-12T15:46:52Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47368engFront. Bioeng. Biotechnol. 8:34210.3389/fbioe.2020.003422296-4185info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:50:13Zoai:repositorio.ul.pt:10451/47368Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:25.584779Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Multi-material implants for temporomandibular joint disc repair : tailored additive manufacturing production
title Multi-material implants for temporomandibular joint disc repair : tailored additive manufacturing production
spellingShingle Multi-material implants for temporomandibular joint disc repair : tailored additive manufacturing production
Moura, Carla
Temporomandibular joint disc
Processing conditions
Poly(ε-caprolactone)
Poly(ethylene glycol) diacrylate
multi-material structures
title_short Multi-material implants for temporomandibular joint disc repair : tailored additive manufacturing production
title_full Multi-material implants for temporomandibular joint disc repair : tailored additive manufacturing production
title_fullStr Multi-material implants for temporomandibular joint disc repair : tailored additive manufacturing production
title_full_unstemmed Multi-material implants for temporomandibular joint disc repair : tailored additive manufacturing production
title_sort Multi-material implants for temporomandibular joint disc repair : tailored additive manufacturing production
author Moura, Carla
author_facet Moura, Carla
Trindade, Daniela
Vieira, Milena
Francisco, Luís
Ângelo, David
Alves, Nuno
author_role author
author2 Trindade, Daniela
Vieira, Milena
Francisco, Luís
Ângelo, David
Alves, Nuno
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Moura, Carla
Trindade, Daniela
Vieira, Milena
Francisco, Luís
Ângelo, David
Alves, Nuno
dc.subject.por.fl_str_mv Temporomandibular joint disc
Processing conditions
Poly(ε-caprolactone)
Poly(ethylene glycol) diacrylate
multi-material structures
topic Temporomandibular joint disc
Processing conditions
Poly(ε-caprolactone)
Poly(ethylene glycol) diacrylate
multi-material structures
description Copyright © 2020 Moura, Trindade, Vieira, Francisco, Ângelo and Alves. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-04-12T15:46:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47368
url http://hdl.handle.net/10451/47368
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front. Bioeng. Biotechnol. 8:342
10.3389/fbioe.2020.00342
2296-4185
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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