COVID-19 mRNA vaccine and antibody response in lactating women
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/126480 |
Resumo: | Funding Information: We thank Florian Krammer (Icahn School of Medicine at Mount Sinai, New York, USA) for kindly providing SARS-CoV-2 spike expression plasmids and Paula Alves, Pedro Cruz and Rute Castro from IBET for protein production and the support. Funding Information: This work was supported by Gilead Génese (PGG/009/2017) and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) to HS. HS and JG is supported by FCT through CEECIND/01049/2020 and PD/BD/128343/2017, respectively. ELISA assay was developed in the context of a Serology4COVID consortium, in which Instituto de Biologia Experimental e Tecnológica (IBET) produced and purified the Spike protein. The present publication was funded by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Publisher Copyright: © 2021, The Author(s). |
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COVID-19 mRNA vaccine and antibody response in lactating womena prospective cohort studyAntibodiesBreastfeedingCovid-19mRNA vaccinationObstetrics and GynaecologySDG 3 - Good Health and Well-beingFunding Information: We thank Florian Krammer (Icahn School of Medicine at Mount Sinai, New York, USA) for kindly providing SARS-CoV-2 spike expression plasmids and Paula Alves, Pedro Cruz and Rute Castro from IBET for protein production and the support. Funding Information: This work was supported by Gilead Génese (PGG/009/2017) and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) to HS. HS and JG is supported by FCT through CEECIND/01049/2020 and PD/BD/128343/2017, respectively. ELISA assay was developed in the context of a Serology4COVID consortium, in which Instituto de Biologia Experimental e Tecnológica (IBET) produced and purified the Spike protein. The present publication was funded by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Publisher Copyright: © 2021, The Author(s).Background: Immunological protection via breastfeeding is well known. The immunological profile of human milk changes during lactation. No clinical trials have been conducted in lactating women with the newest mRNA vaccines against SARS- CoV-2. A Few studies have shown the presence of antibodies in breastmilk after vaccination. The aim of this work is to study possible antibodies transfer via breastmilk and also the immunological characteristics of lactating women compared to non-lactating women, after using the BNT162b2 Pfizer vaccine. Methods: This is a prospective cohort study with a convenience homogenous sample of 24 healthcare workers (14 lactating and 10 non-lactating women) enrolled at the time of COVID-19 vaccination. Clinical data was registered in a questionnaire. Titers of SARS-CoV-2 spike IgG, IgA and IgM were quantified in post vaccination blood and human milk. Antibody quantification was performed by an in-house ELISA to SARS-CoV-2 trimeric spike protein. Results: All women showed immunity after vaccination with positive antibodies for IgM, IgA and IgG antibodies. The dominant serum antibody response was IgG. Modest levels of antibodies in breastmilk of lactating mothers were observed in this study, especially IgG in 42.9%. There was a moderate association between higher titers of IgG and a longer duration of breastfeeding (R= 0.55, p=0.041). Conclusions: Evidence of antibody transfer in human milk after COVID-19 vaccination is scarce. The presence of antibodies in human milk is reported, but immunization through breastfeeding is still to be established.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)RUNCharepe, NadiaGonçalves, JulianaJuliano, A. MargaridaLopes, David G.Canhão, HelenaSoares, HelenaSerrano, e. Fátima2021-10-22T03:43:03Z2021-122021-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/126480eng1471-2393PURE: 33996755https://doi.org/10.1186/s12884-021-04051-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:06:54Zoai:run.unl.pt:10362/126480Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:53.716872Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
COVID-19 mRNA vaccine and antibody response in lactating women a prospective cohort study |
title |
COVID-19 mRNA vaccine and antibody response in lactating women |
spellingShingle |
COVID-19 mRNA vaccine and antibody response in lactating women Charepe, Nadia Antibodies Breastfeeding Covid-19 mRNA vaccination Obstetrics and Gynaecology SDG 3 - Good Health and Well-being |
title_short |
COVID-19 mRNA vaccine and antibody response in lactating women |
title_full |
COVID-19 mRNA vaccine and antibody response in lactating women |
title_fullStr |
COVID-19 mRNA vaccine and antibody response in lactating women |
title_full_unstemmed |
COVID-19 mRNA vaccine and antibody response in lactating women |
title_sort |
COVID-19 mRNA vaccine and antibody response in lactating women |
author |
Charepe, Nadia |
author_facet |
Charepe, Nadia Gonçalves, Juliana Juliano, A. Margarida Lopes, David G. Canhão, Helena Soares, Helena Serrano, e. Fátima |
author_role |
author |
author2 |
Gonçalves, Juliana Juliano, A. Margarida Lopes, David G. Canhão, Helena Soares, Helena Serrano, e. Fátima |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
dc.contributor.author.fl_str_mv |
Charepe, Nadia Gonçalves, Juliana Juliano, A. Margarida Lopes, David G. Canhão, Helena Soares, Helena Serrano, e. Fátima |
dc.subject.por.fl_str_mv |
Antibodies Breastfeeding Covid-19 mRNA vaccination Obstetrics and Gynaecology SDG 3 - Good Health and Well-being |
topic |
Antibodies Breastfeeding Covid-19 mRNA vaccination Obstetrics and Gynaecology SDG 3 - Good Health and Well-being |
description |
Funding Information: We thank Florian Krammer (Icahn School of Medicine at Mount Sinai, New York, USA) for kindly providing SARS-CoV-2 spike expression plasmids and Paula Alves, Pedro Cruz and Rute Castro from IBET for protein production and the support. Funding Information: This work was supported by Gilead Génese (PGG/009/2017) and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) to HS. HS and JG is supported by FCT through CEECIND/01049/2020 and PD/BD/128343/2017, respectively. ELISA assay was developed in the context of a Serology4COVID consortium, in which Instituto de Biologia Experimental e Tecnológica (IBET) produced and purified the Spike protein. The present publication was funded by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020). Publisher Copyright: © 2021, The Author(s). |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-22T03:43:03Z 2021-12 2021-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/126480 |
url |
http://hdl.handle.net/10362/126480 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1471-2393 PURE: 33996755 https://doi.org/10.1186/s12884-021-04051-6 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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