Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/27117 https://doi.org/10.1016/j.pneurobio.2013.10.002 |
Resumo: | Neuropeptide Y (NPY) and NPY receptors are widely expressed in the central nervous system, including the retina. Retinal cells, in particular neurons, astrocytes, and Müller, microglial and endothelial cells express this peptide and its receptors (Y1, Y2, Y4 and/or Y5). Several studies have shown that NPY is expressed in the retina of various mammalian and non-mammalian species. However, studies analyzing the distribution of NPY receptors in the retina are still scarce. Although the physiological roles of NPY in the retina have not been completely elucidated, its early expression strongly suggests that NPY may be involved in the development of retinal circuitry. NPY inhibits the increase in [Ca2+]i triggered by elevated KCl in retinal neurons, protects retinal neural cells against toxic insults and induces the proliferation of retinal progenitor cells. In this review, we will focus on the roles of NPY in the retina, specifically proliferation, neuromodulation and neuroprotection. Alterations in the NPY system in the retina might contribute to the pathogenesis of retinal degenerative diseases, such as diabetic retinopathy and glaucoma, and NPY and its receptors might be viewed as potentially novel therapeutic targets. |
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Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotectionNeuropeptide YNPY receptorsRetinaRetinal neural cellsNeuroprotectionNeuromodulationNeuropeptide Y (NPY) and NPY receptors are widely expressed in the central nervous system, including the retina. Retinal cells, in particular neurons, astrocytes, and Müller, microglial and endothelial cells express this peptide and its receptors (Y1, Y2, Y4 and/or Y5). Several studies have shown that NPY is expressed in the retina of various mammalian and non-mammalian species. However, studies analyzing the distribution of NPY receptors in the retina are still scarce. Although the physiological roles of NPY in the retina have not been completely elucidated, its early expression strongly suggests that NPY may be involved in the development of retinal circuitry. NPY inhibits the increase in [Ca2+]i triggered by elevated KCl in retinal neurons, protects retinal neural cells against toxic insults and induces the proliferation of retinal progenitor cells. In this review, we will focus on the roles of NPY in the retina, specifically proliferation, neuromodulation and neuroprotection. Alterations in the NPY system in the retina might contribute to the pathogenesis of retinal degenerative diseases, such as diabetic retinopathy and glaucoma, and NPY and its receptors might be viewed as potentially novel therapeutic targets.Elsevier2014-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/27117http://hdl.handle.net/10316/27117https://doi.org/10.1016/j.pneurobio.2013.10.002engSANTOS-CARVALHO, Ana [et al.] - Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection. "Progress in Neurobiology". ISSN 0301-0082. Vol. 112 (2014) p. 70-790301-0082http://www.sciencedirect.com/science/article/pii/S0301008213001020Santos-Carvalho, AnaÁlvaro, Ana RitaMartins, JoãoAmbrósio, António FranciscoCavadas, Cláudiainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-07-21T10:06:42Zoai:estudogeral.uc.pt:10316/27117Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:35.393142Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection |
title |
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection |
spellingShingle |
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection Santos-Carvalho, Ana Neuropeptide Y NPY receptors Retina Retinal neural cells Neuroprotection Neuromodulation |
title_short |
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection |
title_full |
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection |
title_fullStr |
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection |
title_full_unstemmed |
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection |
title_sort |
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection |
author |
Santos-Carvalho, Ana |
author_facet |
Santos-Carvalho, Ana Álvaro, Ana Rita Martins, João Ambrósio, António Francisco Cavadas, Cláudia |
author_role |
author |
author2 |
Álvaro, Ana Rita Martins, João Ambrósio, António Francisco Cavadas, Cláudia |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos-Carvalho, Ana Álvaro, Ana Rita Martins, João Ambrósio, António Francisco Cavadas, Cláudia |
dc.subject.por.fl_str_mv |
Neuropeptide Y NPY receptors Retina Retinal neural cells Neuroprotection Neuromodulation |
topic |
Neuropeptide Y NPY receptors Retina Retinal neural cells Neuroprotection Neuromodulation |
description |
Neuropeptide Y (NPY) and NPY receptors are widely expressed in the central nervous system, including the retina. Retinal cells, in particular neurons, astrocytes, and Müller, microglial and endothelial cells express this peptide and its receptors (Y1, Y2, Y4 and/or Y5). Several studies have shown that NPY is expressed in the retina of various mammalian and non-mammalian species. However, studies analyzing the distribution of NPY receptors in the retina are still scarce. Although the physiological roles of NPY in the retina have not been completely elucidated, its early expression strongly suggests that NPY may be involved in the development of retinal circuitry. NPY inhibits the increase in [Ca2+]i triggered by elevated KCl in retinal neurons, protects retinal neural cells against toxic insults and induces the proliferation of retinal progenitor cells. In this review, we will focus on the roles of NPY in the retina, specifically proliferation, neuromodulation and neuroprotection. Alterations in the NPY system in the retina might contribute to the pathogenesis of retinal degenerative diseases, such as diabetic retinopathy and glaucoma, and NPY and its receptors might be viewed as potentially novel therapeutic targets. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/27117 http://hdl.handle.net/10316/27117 https://doi.org/10.1016/j.pneurobio.2013.10.002 |
url |
http://hdl.handle.net/10316/27117 https://doi.org/10.1016/j.pneurobio.2013.10.002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
SANTOS-CARVALHO, Ana [et al.] - Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection. "Progress in Neurobiology". ISSN 0301-0082. Vol. 112 (2014) p. 70-79 0301-0082 http://www.sciencedirect.com/science/article/pii/S0301008213001020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133822353145856 |