Recalcitrant Acneiform Eruption Revealing Behçet’s Disease: A Case with Late but Successful Response to Adalimumab
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.75.4.759 |
Resumo: | Behçet's disease is a systemic vasculitis with a chronic-relapsing course, which can lead to significant morbidity and mortality. From the often-compelling challenge of making a prompt diagnosis comes the difficulty in its treatment. We report the case of a patient with an acneiform skin eruption revealing Behçet's disease that was refractory to conventional therapy and later completely responded to adalimumab. Although randomized controlled clinical trials are lacking in the literature, there is already significant evidence supporting anti-TNF agents as a major therapeutic advance in Behçet's disease, particularly in cases that are severe, refractory or intolerant to classical immunosuppression. |
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Recalcitrant Acneiform Eruption Revealing Behçet’s Disease: A Case with Late but Successful Response to AdalimumabErupção Acneiforme Refratária Reveladora de Doença de Behçet: A Propósito de um Caso Clínico com Resposta Tardia mas Eficaz ao AdalimumabAcneiform EruptionsAdalimumabTumor Necrosis Factor-alpha/antagonists & inhibitorsBehcet SyndromeAdalimumabErupções AcneiformesFactor de Necrose Tumoral alfa /antagonistas & inibidoresSíndrome de BehçetBehçet's disease is a systemic vasculitis with a chronic-relapsing course, which can lead to significant morbidity and mortality. From the often-compelling challenge of making a prompt diagnosis comes the difficulty in its treatment. We report the case of a patient with an acneiform skin eruption revealing Behçet's disease that was refractory to conventional therapy and later completely responded to adalimumab. Although randomized controlled clinical trials are lacking in the literature, there is already significant evidence supporting anti-TNF agents as a major therapeutic advance in Behçet's disease, particularly in cases that are severe, refractory or intolerant to classical immunosuppression.A doença de Behçet é uma vasculite sistémica crónica e recidivante que pode levar a um aumento significativo da morbilidade e mortalidade. Após superar o desafio em fazer o seu diagnóstico atempado, que muitas vezes se impõe, surge a dificuldade no seu tratamento. Relata-se um caso de um doente que se apresentou com uma erupção acneiforme reveladora de doença de Behçet, refratária à terapia convencional, que respondeu mais tarde e completamente, ao adalimumab. Na literatura científica, embora faltem ensaios clínicos controlados e randomizados, há já evidência significativa que suporta o papel dos agentes anti-TNF como um importante avanço terapêutico na doença de Behçet, particularmente em casos graves, refratários ou intolerantes à imunossupressão clássica.Sociedade Portuguesa de Dermatologia e Venereologia2018-01-26T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfimage/tiffimage/tiffimage/tiffhttps://doi.org/10.29021/spdv.75.4.759oai:ojs.revista.spdv.com.pt:article/759Journal of the Portuguese Society of Dermatology and Venereology; Vol 75 No 4 (2017): Outubro - Dezembro; 421-424Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 75 n. 4 (2017): Outubro - Dezembro; 421-4242182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spdv.com.pt/index.php/spdv/article/view/759https://doi.org/10.29021/spdv.75.4.759https://revista.spdv.com.pt/index.php/spdv/article/view/759/535https://revista.spdv.com.pt/index.php/spdv/article/view/759/724https://revista.spdv.com.pt/index.php/spdv/article/view/759/725https://revista.spdv.com.pt/index.php/spdv/article/view/759/726Vide, JúliaLopes, SofiaMagina, SofiaAzevedo, Filomenainfo:eu-repo/semantics/openAccess2022-10-06T12:35:02Zoai:ojs.revista.spdv.com.pt:article/759Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:01.951436Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Recalcitrant Acneiform Eruption Revealing Behçet’s Disease: A Case with Late but Successful Response to Adalimumab Erupção Acneiforme Refratária Reveladora de Doença de Behçet: A Propósito de um Caso Clínico com Resposta Tardia mas Eficaz ao Adalimumab |
title |
Recalcitrant Acneiform Eruption Revealing Behçet’s Disease: A Case with Late but Successful Response to Adalimumab |
spellingShingle |
Recalcitrant Acneiform Eruption Revealing Behçet’s Disease: A Case with Late but Successful Response to Adalimumab Vide, Júlia Acneiform Eruptions Adalimumab Tumor Necrosis Factor-alpha/antagonists & inhibitors Behcet Syndrome Adalimumab Erupções Acneiformes Factor de Necrose Tumoral alfa /antagonistas & inibidores Síndrome de Behçet |
title_short |
Recalcitrant Acneiform Eruption Revealing Behçet’s Disease: A Case with Late but Successful Response to Adalimumab |
title_full |
Recalcitrant Acneiform Eruption Revealing Behçet’s Disease: A Case with Late but Successful Response to Adalimumab |
title_fullStr |
Recalcitrant Acneiform Eruption Revealing Behçet’s Disease: A Case with Late but Successful Response to Adalimumab |
title_full_unstemmed |
Recalcitrant Acneiform Eruption Revealing Behçet’s Disease: A Case with Late but Successful Response to Adalimumab |
title_sort |
Recalcitrant Acneiform Eruption Revealing Behçet’s Disease: A Case with Late but Successful Response to Adalimumab |
author |
Vide, Júlia |
author_facet |
Vide, Júlia Lopes, Sofia Magina, Sofia Azevedo, Filomena |
author_role |
author |
author2 |
Lopes, Sofia Magina, Sofia Azevedo, Filomena |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Vide, Júlia Lopes, Sofia Magina, Sofia Azevedo, Filomena |
dc.subject.por.fl_str_mv |
Acneiform Eruptions Adalimumab Tumor Necrosis Factor-alpha/antagonists & inhibitors Behcet Syndrome Adalimumab Erupções Acneiformes Factor de Necrose Tumoral alfa /antagonistas & inibidores Síndrome de Behçet |
topic |
Acneiform Eruptions Adalimumab Tumor Necrosis Factor-alpha/antagonists & inhibitors Behcet Syndrome Adalimumab Erupções Acneiformes Factor de Necrose Tumoral alfa /antagonistas & inibidores Síndrome de Behçet |
description |
Behçet's disease is a systemic vasculitis with a chronic-relapsing course, which can lead to significant morbidity and mortality. From the often-compelling challenge of making a prompt diagnosis comes the difficulty in its treatment. We report the case of a patient with an acneiform skin eruption revealing Behçet's disease that was refractory to conventional therapy and later completely responded to adalimumab. Although randomized controlled clinical trials are lacking in the literature, there is already significant evidence supporting anti-TNF agents as a major therapeutic advance in Behçet's disease, particularly in cases that are severe, refractory or intolerant to classical immunosuppression. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-26T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.75.4.759 oai:ojs.revista.spdv.com.pt:article/759 |
url |
https://doi.org/10.29021/spdv.75.4.759 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/759 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/759 https://doi.org/10.29021/spdv.75.4.759 https://revista.spdv.com.pt/index.php/spdv/article/view/759/535 https://revista.spdv.com.pt/index.php/spdv/article/view/759/724 https://revista.spdv.com.pt/index.php/spdv/article/view/759/725 https://revista.spdv.com.pt/index.php/spdv/article/view/759/726 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf image/tiff image/tiff image/tiff |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 75 No 4 (2017): Outubro - Dezembro; 421-424 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 75 n. 4 (2017): Outubro - Dezembro; 421-424 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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