Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materials

Detalhes bibliográficos
Autor(a) principal: Machado, Jorge
Data de Publicação: 2020
Outros Autores: Carvalho, Patrícia M. S., Félix, Ana, Doutel, Delfin, Santos, José Paulo, Carvalho, Maria Luísa, Pessanha, Sofia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/114330
Resumo: UID/FIS/04559/2019 to LIBPhys-UNL from the FCT/MCTES/PIDDAC, Portugal. FCT contract No. PD/BD/128324/2017.
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spelling Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materialsAnalytical ChemistrySpectroscopyUID/FIS/04559/2019 to LIBPhys-UNL from the FCT/MCTES/PIDDAC, Portugal. FCT contract No. PD/BD/128324/2017.In this work, we aim at achieving the most accurate quantitative determination of elements in human tissues by means of X-ray Fluorescence spectrometry using the external calibration approach. A calibration curve built using a set of certified reference materials (CRM) of animal tissue was compared with the one obtained with a set of CRMs of plants and leaves with lower atomic number Z but with correction of the matrix using the scattering peaks of the X-ray tube anode. Finally, a calibration curve combining the two sets of CRMs was built and the accuracy of the quantification using the three methods was compared and a more precise method of quantification was obtained. This improved approach was tested on five paired samples of normal and tumour human tissue. Despite the high heterogeneity of the samples, and given the improvement in accuracy of the measurements, significant differences were found in the elemental concentration of low-Z elements. This journal isLIBPhys-UNLDF – Departamento de FísicaNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNMachado, JorgeCarvalho, Patrícia M. S.Félix, AnaDoutel, DelfinSantos, José PauloCarvalho, Maria LuísaPessanha, Sofia2022-03-31T00:31:41Z2020-122020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/114330eng0267-9477PURE: 27916504https://doi.org/10.1039/d0ja00307ginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-10T15:59:02ZPortal AgregadorONG
dc.title.none.fl_str_mv Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materials
title Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materials
spellingShingle Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materials
Machado, Jorge
Analytical Chemistry
Spectroscopy
title_short Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materials
title_full Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materials
title_fullStr Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materials
title_full_unstemmed Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materials
title_sort Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materials
author Machado, Jorge
author_facet Machado, Jorge
Carvalho, Patrícia M. S.
Félix, Ana
Doutel, Delfin
Santos, José Paulo
Carvalho, Maria Luísa
Pessanha, Sofia
author_role author
author2 Carvalho, Patrícia M. S.
Félix, Ana
Doutel, Delfin
Santos, José Paulo
Carvalho, Maria Luísa
Pessanha, Sofia
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv LIBPhys-UNL
DF – Departamento de Física
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Machado, Jorge
Carvalho, Patrícia M. S.
Félix, Ana
Doutel, Delfin
Santos, José Paulo
Carvalho, Maria Luísa
Pessanha, Sofia
dc.subject.por.fl_str_mv Analytical Chemistry
Spectroscopy
topic Analytical Chemistry
Spectroscopy
description UID/FIS/04559/2019 to LIBPhys-UNL from the FCT/MCTES/PIDDAC, Portugal. FCT contract No. PD/BD/128324/2017.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
2020-12-01T00:00:00Z
2022-03-31T00:31:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/114330
url http://hdl.handle.net/10362/114330
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0267-9477
PURE: 27916504
https://doi.org/10.1039/d0ja00307g
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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