The role of autophagy in cancer chemotherapy drug resistance
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.48797/sl.2022.10 |
Resumo: | About 650,000 cancer patients are treated with chemotherapy drugs each year. There have been tremendous advances in this field over the past several decades. However, major obstacles remain. One of these obstacles is that cancer cells become drug resistant. 90% of clinical failures in chemotherapy treatment are because of drug resistance. In this review, we focus on the role of autophagy in cancer cell drug resistance. In non-cancerous cells, autophagy is constitutively active, but can be augmented by nutrient deprivation, reactive oxygen species (ROS), and pathogen invasion. It can either keep cells alive or trigger apoptosis, depending on the degree of disruption of cell homeostasis. These are critical considerations in cancer treatment: autophagy can either kill cells or it can keep cancer cells alive, furthering drug resistance. In cancer cells, chemotherapy typically triggers ROS. ROS then activate autophagy through several pathways. Thus, understanding how autophagy works in cancer cells that have been exposed to drugs can be a valuable weapon to combat drug resistance. |
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The role of autophagy in cancer chemotherapy drug resistanceautophagychemotherapydrug resistancecancerreactive oxygen speciesAbout 650,000 cancer patients are treated with chemotherapy drugs each year. There have been tremendous advances in this field over the past several decades. However, major obstacles remain. One of these obstacles is that cancer cells become drug resistant. 90% of clinical failures in chemotherapy treatment are because of drug resistance. In this review, we focus on the role of autophagy in cancer cell drug resistance. In non-cancerous cells, autophagy is constitutively active, but can be augmented by nutrient deprivation, reactive oxygen species (ROS), and pathogen invasion. It can either keep cells alive or trigger apoptosis, depending on the degree of disruption of cell homeostasis. These are critical considerations in cancer treatment: autophagy can either kill cells or it can keep cancer cells alive, furthering drug resistance. In cancer cells, chemotherapy typically triggers ROS. ROS then activate autophagy through several pathways. Thus, understanding how autophagy works in cancer cells that have been exposed to drugs can be a valuable weapon to combat drug resistance.IUCS-CESPU Publishing2022-05-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.48797/sl.2022.10https://doi.org/10.48797/sl.2022.10Scientific Letters; Vol. 1 No. 1 (2022); 42795-5117reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://publicacoes.cespu.pt/index.php/sl/article/view/10https://publicacoes.cespu.pt/index.php/sl/article/view/10/6Copyright (c) 2022 Monireh Asoudeh, Paul Dalhaimerinfo:eu-repo/semantics/openAccessAsoudeh, MonirehDalhaimer, Paul2023-04-22T08:45:12Zoai:publicacoes.cespu.pt:article/10Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:46:16.551683Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The role of autophagy in cancer chemotherapy drug resistance |
title |
The role of autophagy in cancer chemotherapy drug resistance |
spellingShingle |
The role of autophagy in cancer chemotherapy drug resistance Asoudeh, Monireh autophagy chemotherapy drug resistance cancer reactive oxygen species |
title_short |
The role of autophagy in cancer chemotherapy drug resistance |
title_full |
The role of autophagy in cancer chemotherapy drug resistance |
title_fullStr |
The role of autophagy in cancer chemotherapy drug resistance |
title_full_unstemmed |
The role of autophagy in cancer chemotherapy drug resistance |
title_sort |
The role of autophagy in cancer chemotherapy drug resistance |
author |
Asoudeh, Monireh |
author_facet |
Asoudeh, Monireh Dalhaimer, Paul |
author_role |
author |
author2 |
Dalhaimer, Paul |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Asoudeh, Monireh Dalhaimer, Paul |
dc.subject.por.fl_str_mv |
autophagy chemotherapy drug resistance cancer reactive oxygen species |
topic |
autophagy chemotherapy drug resistance cancer reactive oxygen species |
description |
About 650,000 cancer patients are treated with chemotherapy drugs each year. There have been tremendous advances in this field over the past several decades. However, major obstacles remain. One of these obstacles is that cancer cells become drug resistant. 90% of clinical failures in chemotherapy treatment are because of drug resistance. In this review, we focus on the role of autophagy in cancer cell drug resistance. In non-cancerous cells, autophagy is constitutively active, but can be augmented by nutrient deprivation, reactive oxygen species (ROS), and pathogen invasion. It can either keep cells alive or trigger apoptosis, depending on the degree of disruption of cell homeostasis. These are critical considerations in cancer treatment: autophagy can either kill cells or it can keep cancer cells alive, furthering drug resistance. In cancer cells, chemotherapy typically triggers ROS. ROS then activate autophagy through several pathways. Thus, understanding how autophagy works in cancer cells that have been exposed to drugs can be a valuable weapon to combat drug resistance. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-13 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.48797/sl.2022.10 https://doi.org/10.48797/sl.2022.10 |
url |
https://doi.org/10.48797/sl.2022.10 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://publicacoes.cespu.pt/index.php/sl/article/view/10 https://publicacoes.cespu.pt/index.php/sl/article/view/10/6 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Monireh Asoudeh, Paul Dalhaimer info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Monireh Asoudeh, Paul Dalhaimer |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
IUCS-CESPU Publishing |
publisher.none.fl_str_mv |
IUCS-CESPU Publishing |
dc.source.none.fl_str_mv |
Scientific Letters; Vol. 1 No. 1 (2022); 4 2795-5117 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130934435381248 |