Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.5/22015 |
Resumo: | Aristotelia serrata, wineberry, or makomako, is a small deciduous fast-growing shrub of New Zealand that produces a berry. In this study leaf extracts were produced using ultra-sound technology. Alzheimer’s Disease is a progressive mental deterioration related with ageing and senility, in which approved drugs for treatment inhibit butyrylcholinesterase(BChE), an enzyme present in the human brain. The ultrasound assisted extraction of natural anti-butyrylcholinesterase and antioxidants from this plant, and the yield of extraction were optimized using response surface methodology. The effect of acoustic power density(0.13–0.65 W/mL), time (1–20 min), and ethanol concentration (20–80%) on BChE inhibition,antioxidant activity, and extraction yield was determined, the optimum extraction conditions being 0.53 W/mL, 17.12 min and 74% ethanol. The optimized extracts were produced to experimentally validate the predicted responses. The IC50 concentrations were experimentally determined (26.2 ug/mL for BChE, 5.5 ug/mL for radical scavenging activity). A. serrata leaf extracts have potential to be used as complements to medicines traditionally used for memory dysfunction |
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Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extractionplant extractsultrasound extractionoptimizationyieldantioxidant activityAlzheimer’s DiseaseAristotelia serrata, wineberry, or makomako, is a small deciduous fast-growing shrub of New Zealand that produces a berry. In this study leaf extracts were produced using ultra-sound technology. Alzheimer’s Disease is a progressive mental deterioration related with ageing and senility, in which approved drugs for treatment inhibit butyrylcholinesterase(BChE), an enzyme present in the human brain. The ultrasound assisted extraction of natural anti-butyrylcholinesterase and antioxidants from this plant, and the yield of extraction were optimized using response surface methodology. The effect of acoustic power density(0.13–0.65 W/mL), time (1–20 min), and ethanol concentration (20–80%) on BChE inhibition,antioxidant activity, and extraction yield was determined, the optimum extraction conditions being 0.53 W/mL, 17.12 min and 74% ethanol. The optimized extracts were produced to experimentally validate the predicted responses. The IC50 concentrations were experimentally determined (26.2 ug/mL for BChE, 5.5 ug/mL for radical scavenging activity). A. serrata leaf extracts have potential to be used as complements to medicines traditionally used for memory dysfunctionElsevierRepositório da Universidade de LisboaMajid, HafizSilva, Filipa V.M.2021-09-27T09:46:40Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/22015engH. Majid, F.V.M. Silva. 2020. Improvement of butyrylcholinesterase enzyme inhibition and medicinal properties of extracts of Aristotelia serrata leaves by ultrasound extraction. Food and Bioproducts Processing 124, 445-454https://doi.org/10.1016/j.fbp.2020.10.004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:51:34Zoai:www.repository.utl.pt:10400.5/22015Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:06:31.785896Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
title |
Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
spellingShingle |
Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction Majid, Hafiz plant extracts ultrasound extraction optimization yield antioxidant activity Alzheimer’s Disease |
title_short |
Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
title_full |
Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
title_fullStr |
Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
title_full_unstemmed |
Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
title_sort |
Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
author |
Majid, Hafiz |
author_facet |
Majid, Hafiz Silva, Filipa V.M. |
author_role |
author |
author2 |
Silva, Filipa V.M. |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Majid, Hafiz Silva, Filipa V.M. |
dc.subject.por.fl_str_mv |
plant extracts ultrasound extraction optimization yield antioxidant activity Alzheimer’s Disease |
topic |
plant extracts ultrasound extraction optimization yield antioxidant activity Alzheimer’s Disease |
description |
Aristotelia serrata, wineberry, or makomako, is a small deciduous fast-growing shrub of New Zealand that produces a berry. In this study leaf extracts were produced using ultra-sound technology. Alzheimer’s Disease is a progressive mental deterioration related with ageing and senility, in which approved drugs for treatment inhibit butyrylcholinesterase(BChE), an enzyme present in the human brain. The ultrasound assisted extraction of natural anti-butyrylcholinesterase and antioxidants from this plant, and the yield of extraction were optimized using response surface methodology. The effect of acoustic power density(0.13–0.65 W/mL), time (1–20 min), and ethanol concentration (20–80%) on BChE inhibition,antioxidant activity, and extraction yield was determined, the optimum extraction conditions being 0.53 W/mL, 17.12 min and 74% ethanol. The optimized extracts were produced to experimentally validate the predicted responses. The IC50 concentrations were experimentally determined (26.2 ug/mL for BChE, 5.5 ug/mL for radical scavenging activity). A. serrata leaf extracts have potential to be used as complements to medicines traditionally used for memory dysfunction |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-09-27T09:46:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.5/22015 |
url |
http://hdl.handle.net/10400.5/22015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
H. Majid, F.V.M. Silva. 2020. Improvement of butyrylcholinesterase enzyme inhibition and medicinal properties of extracts of Aristotelia serrata leaves by ultrasound extraction. Food and Bioproducts Processing 124, 445-454 https://doi.org/10.1016/j.fbp.2020.10.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131157772632064 |