Ionic Levothyroxine Formulations

Detalhes bibliográficos
Autor(a) principal: Barreira, António
Data de Publicação: 2023
Outros Autores: Santos, Andreia F. M., Dionísio, Madalena, Jesus, Ana R., Duarte, Ana Rita C., Petrovski, Željko, Paninho, Ana B., Ventura, Márcia G., Branco, Luís C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154627
Resumo: Funding Information: Ana R. Jesus and Ana Rita C. Duarte acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme, under grant agreement No ERC-2016-CoG 725034. Publisher Copyright: © 2023 by the authors.
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spelling Ionic Levothyroxine FormulationsSynthesis, Bioavailability, and Cytotoxicity Studiescytotoxicityionic formulationslevothyroxine (T4)permeabilitysolubilityT4 based ionic liquids (T4-ILs)CatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistryFunding Information: Ana R. Jesus and Ana Rita C. Duarte acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme, under grant agreement No ERC-2016-CoG 725034. Publisher Copyright: © 2023 by the authors.Thyroid diseases affect a considerable portion of the population, with hypothyroidism being one of the most commonly reported thyroid diseases. Levothyroxine (T4) is clinically used to treat hypothyroidism and suppress thyroid stimulating hormone secretion in other thyroid diseases. In this work, an attempt to improve T4 solubility is made through the synthesis of ionic liquids (ILs) based on this drug. In this context, [Na][T4] was combined with choline [Ch]+ and 1-(2-hydroxyethyl)-3-methylimidazolium [C2OHMiM]+ cations in order to prepare the desired T4-ILs. All compounds were characterized by NMR, ATR-FTIR, elemental analysis, and DSC, aiming to check their chemical structure, purities, and thermal properties. The serum, water, and PBS solubilities of the T4-ILs were compared to [Na][T4], as well as the permeability assays. It is important to note an improved adsorption capacity, in which no significant cytotoxicity was observed against L929 cells. [C2OHMiM][T4] seems to be a good alternative to the commercial levothyroxine sodium salt with promising bioavailability.DQ - Departamento de QuímicaLAQV@REQUIMTERUNBarreira, AntónioSantos, Andreia F. M.Dionísio, MadalenaJesus, Ana R.Duarte, Ana Rita C.Petrovski, ŽeljkoPaninho, Ana B.Ventura, Márcia G.Branco, Luís C.2023-06-29T22:17:50Z2023-05-162023-05-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/154627eng1661-6596PURE: 64822827https://doi.org/10.3390/ijms24108822info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:07Zoai:run.unl.pt:10362/154627Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:42.436682Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ionic Levothyroxine Formulations
Synthesis, Bioavailability, and Cytotoxicity Studies
title Ionic Levothyroxine Formulations
spellingShingle Ionic Levothyroxine Formulations
Barreira, António
cytotoxicity
ionic formulations
levothyroxine (T4)
permeability
solubility
T4 based ionic liquids (T4-ILs)
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
title_short Ionic Levothyroxine Formulations
title_full Ionic Levothyroxine Formulations
title_fullStr Ionic Levothyroxine Formulations
title_full_unstemmed Ionic Levothyroxine Formulations
title_sort Ionic Levothyroxine Formulations
author Barreira, António
author_facet Barreira, António
Santos, Andreia F. M.
Dionísio, Madalena
Jesus, Ana R.
Duarte, Ana Rita C.
Petrovski, Željko
Paninho, Ana B.
Ventura, Márcia G.
Branco, Luís C.
author_role author
author2 Santos, Andreia F. M.
Dionísio, Madalena
Jesus, Ana R.
Duarte, Ana Rita C.
Petrovski, Željko
Paninho, Ana B.
Ventura, Márcia G.
Branco, Luís C.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Barreira, António
Santos, Andreia F. M.
Dionísio, Madalena
Jesus, Ana R.
Duarte, Ana Rita C.
Petrovski, Željko
Paninho, Ana B.
Ventura, Márcia G.
Branco, Luís C.
dc.subject.por.fl_str_mv cytotoxicity
ionic formulations
levothyroxine (T4)
permeability
solubility
T4 based ionic liquids (T4-ILs)
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
topic cytotoxicity
ionic formulations
levothyroxine (T4)
permeability
solubility
T4 based ionic liquids (T4-ILs)
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
description Funding Information: Ana R. Jesus and Ana Rita C. Duarte acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme, under grant agreement No ERC-2016-CoG 725034. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-29T22:17:50Z
2023-05-16
2023-05-16T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154627
url http://hdl.handle.net/10362/154627
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
PURE: 64822827
https://doi.org/10.3390/ijms24108822
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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