Delayed Diagnosis of Occult Phosphaturic Mesenchymal Tumor in the Foot
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4116 |
Resumo: | Phosphaturic mesenchymal tumors are the main cause of tumor-induced osteomalacia, a distinctive paraneoplastic syndrome mediated by overproduction of fibroblast growth factor 23, that leads to renal phosphate wasting and hypophosphatemia. Diagnosis of this mesenchymal tumors is difficult and usually delayed for several years. We present the case of a 70-years-old-male with generalized bone pain, multiple pathological fractures and persistent hypophosphatemia, diagnosed with tumor-induced osteomalacia after 4 years of the onset of symptoms. The tumor was localized in the forefoot using Gallium 68-DOTANOC positron emission tomography-computed tomography and successfully surgically treated. This case report highlights the importance of recognizing these rare tumors, as early diagnosis can prevent long-term morbidity. |
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Delayed Diagnosis of Occult Phosphaturic Mesenchymal Tumor in the FootHCC ORTPhosphaturic Mesenchymal TumorsTumor-Induced OsteomalaciaFibroblast Growth Factor 23HypophosphatemiaPhosphaturic mesenchymal tumors are the main cause of tumor-induced osteomalacia, a distinctive paraneoplastic syndrome mediated by overproduction of fibroblast growth factor 23, that leads to renal phosphate wasting and hypophosphatemia. Diagnosis of this mesenchymal tumors is difficult and usually delayed for several years. We present the case of a 70-years-old-male with generalized bone pain, multiple pathological fractures and persistent hypophosphatemia, diagnosed with tumor-induced osteomalacia after 4 years of the onset of symptoms. The tumor was localized in the forefoot using Gallium 68-DOTANOC positron emission tomography-computed tomography and successfully surgically treated. This case report highlights the importance of recognizing these rare tumors, as early diagnosis can prevent long-term morbidity.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPECorreia, JMachado, MGonçalves, RJonge, FMicaelo, MPedrosa, CPortela, J2022-06-15T14:05:18Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4116engRadiol Case Rep. 2021 Apr 9;16(6):1355-1362.10.1016/j.radcr.2021.03.015.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:45:24Zoai:repositorio.chlc.min-saude.pt:10400.17/4116Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:27.510883Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Delayed Diagnosis of Occult Phosphaturic Mesenchymal Tumor in the Foot |
title |
Delayed Diagnosis of Occult Phosphaturic Mesenchymal Tumor in the Foot |
spellingShingle |
Delayed Diagnosis of Occult Phosphaturic Mesenchymal Tumor in the Foot Correia, J HCC ORT Phosphaturic Mesenchymal Tumors Tumor-Induced Osteomalacia Fibroblast Growth Factor 23 Hypophosphatemia |
title_short |
Delayed Diagnosis of Occult Phosphaturic Mesenchymal Tumor in the Foot |
title_full |
Delayed Diagnosis of Occult Phosphaturic Mesenchymal Tumor in the Foot |
title_fullStr |
Delayed Diagnosis of Occult Phosphaturic Mesenchymal Tumor in the Foot |
title_full_unstemmed |
Delayed Diagnosis of Occult Phosphaturic Mesenchymal Tumor in the Foot |
title_sort |
Delayed Diagnosis of Occult Phosphaturic Mesenchymal Tumor in the Foot |
author |
Correia, J |
author_facet |
Correia, J Machado, M Gonçalves, R Jonge, F Micaelo, M Pedrosa, C Portela, J |
author_role |
author |
author2 |
Machado, M Gonçalves, R Jonge, F Micaelo, M Pedrosa, C Portela, J |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Correia, J Machado, M Gonçalves, R Jonge, F Micaelo, M Pedrosa, C Portela, J |
dc.subject.por.fl_str_mv |
HCC ORT Phosphaturic Mesenchymal Tumors Tumor-Induced Osteomalacia Fibroblast Growth Factor 23 Hypophosphatemia |
topic |
HCC ORT Phosphaturic Mesenchymal Tumors Tumor-Induced Osteomalacia Fibroblast Growth Factor 23 Hypophosphatemia |
description |
Phosphaturic mesenchymal tumors are the main cause of tumor-induced osteomalacia, a distinctive paraneoplastic syndrome mediated by overproduction of fibroblast growth factor 23, that leads to renal phosphate wasting and hypophosphatemia. Diagnosis of this mesenchymal tumors is difficult and usually delayed for several years. We present the case of a 70-years-old-male with generalized bone pain, multiple pathological fractures and persistent hypophosphatemia, diagnosed with tumor-induced osteomalacia after 4 years of the onset of symptoms. The tumor was localized in the forefoot using Gallium 68-DOTANOC positron emission tomography-computed tomography and successfully surgically treated. This case report highlights the importance of recognizing these rare tumors, as early diagnosis can prevent long-term morbidity. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2022-06-15T14:05:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4116 |
url |
http://hdl.handle.net/10400.17/4116 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Radiol Case Rep. 2021 Apr 9;16(6):1355-1362. 10.1016/j.radcr.2021.03.015. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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