Serum levels of TNF-α, IL-6 and IL-10 in haemodialysis and renal transplant patients and in healthy subjects

• Autor(a) principal: Alwahaibi,Nasar Yousuf
• Data de Publicação: 2016
• Outros Autores: Alissaei,Halima Khalfan, Alshihi,Sara Abdullah, Alabri,Nadia, Albalushi,Samya Sulaiman, Albalooshi,Mohammed
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692016000300003
• topic: TNF-α; IL-6; IL-10; chronic renal failure; hemodialysis; renal transplant

Background: Inflammatory processes seem to play an important role in the development of atherosclerosis. Recurrent or chronic inflammatory processes are common in individuals with end-stage renal disease. There isno consensus approach to assess the degree of severity of inflammation in individuals with kidney disease. In recent years, there has been a growing interest in the role of various cytokines in chronic kidney disease (CKD). Cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) are mediators of inflammation that may play an important role in CKD. Interleukin 10 (IL-10) is a regulatory cytokine that seems to play a role in limiting inflammatory processes. Aim: The aim of this study was to evaluate the serum levels of TNF- α, IL-6 and IL-10 in a population of haemodialysis and renal transplant patients and in healthy subjects. Methods: This was a cross-sectional study. In 152 participants inflammation was assessed by measuring TNF-α, IL-6 and IL-10. The study included 53 haemodialysis patients, 45 renal transplant patients and 54 healthy subjects. Results: Serum levels of TNF-α were significantly higher in haemodialysis and renal transplant patients than in healthy subjects (40.2±10.8 vs 5.2±1.7 pg/mL; p<0.05; and 16.1±5.9 vs 5.2±1.7 pg/mL; p<0.05, respectively). Serum levels of IL-6 were significantly higher in haemodialysis patients than in healthy subjects (40.2±41.4 vs 16.4±5.4 pg/mL; p<0.05), whereas no significant difference was found between renal transplant patients and healthy subjects (20.1±8.3 vs 16.4±5.4 pg/mL; p=NS). Serum levels of IL-10 were significantly higher in haemodialysis and renal transplant patients than in healthy subjects (23.8±4.5 vs 10.5±3.9 pg/mL; p<0.05; and 19.4±3.1 vs 10.5±3.9 pg/mL; p<0.05, respectively). Conclusion: This study showed higher levels of inflammatory markers (TNF-α, IL-6) and of the regulatory cytokine IL-10 in haemodialysis patients than in healthy controls and higher levels of TNF-α and IL-10 in renal transplant patients than in healthy controls. In haemodialysis patients, increased levels of inflammatory markers usually predict a poor outcome