Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni

Detalhes bibliográficos
Autor(a) principal: Oliveira, Katia C.
Data de Publicação: 2019
Outros Autores: Cardoso, Rita, Dos Santos, Antonio C., Fernandes, Rúben, Botelho, Monica C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/15046
Resumo: Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system.
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spelling Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoniSteroid hormonesSchistosoma mansoni infectionHost-parasite interactionEstradiolTestosteroneProgesteroneInfertilityObjective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system.Repositório Científico do Instituto Politécnico do PortoOliveira, Katia C.Cardoso, RitaDos Santos, Antonio C.Fernandes, RúbenBotelho, Monica C.2020-12-10T01:30:25Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/15046engOliveira, K. C., Cardoso, R., Santos, A. C. D., Fernandes, R., & Botelho, M. C. (2019). Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni. Endocrine, Metabolic & Immune Disorders - Drug Targets, 19(8), 1122–1126.10.2174/1871530319666190529121204info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-10T01:49:14Zoai:recipp.ipp.pt:10400.22/15046Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:49.886726Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni
title Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni
spellingShingle Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni
Oliveira, Katia C.
Steroid hormones
Schistosoma mansoni infection
Host-parasite interaction
Estradiol
Testosterone
Progesterone
Infertility
title_short Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni
title_full Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni
title_fullStr Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni
title_full_unstemmed Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni
title_sort Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni
author Oliveira, Katia C.
author_facet Oliveira, Katia C.
Cardoso, Rita
Dos Santos, Antonio C.
Fernandes, Rúben
Botelho, Monica C.
author_role author
author2 Cardoso, Rita
Dos Santos, Antonio C.
Fernandes, Rúben
Botelho, Monica C.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Oliveira, Katia C.
Cardoso, Rita
Dos Santos, Antonio C.
Fernandes, Rúben
Botelho, Monica C.
dc.subject.por.fl_str_mv Steroid hormones
Schistosoma mansoni infection
Host-parasite interaction
Estradiol
Testosterone
Progesterone
Infertility
topic Steroid hormones
Schistosoma mansoni infection
Host-parasite interaction
Estradiol
Testosterone
Progesterone
Infertility
description Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2020-12-10T01:30:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/15046
url http://hdl.handle.net/10400.22/15046
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oliveira, K. C., Cardoso, R., Santos, A. C. D., Fernandes, R., & Botelho, M. C. (2019). Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni. Endocrine, Metabolic & Immune Disorders - Drug Targets, 19(8), 1122–1126.
10.2174/1871530319666190529121204
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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