Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata

Detalhes bibliográficos
Autor(a) principal: Susano, Patrícia
Data de Publicação: 2021
Outros Autores: Silva, Joana, Alves, Celso, Martins, Alice, Gaspar, Helena, Pinteus, Susete, Mouga, Teresa, Goettert, Márcia Ines, Petrovski, Željko, Branco, Luís B., Pedrosa, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/131848
Resumo: UID/04292/2020 InSAICT-PAC/0019/2015-LISBOA-01-0145-FEDER-016405 POCI-01-0145-FEDER-029250
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spelling Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costataalgaeanti-enzymaticanti-inflammatoryantimicrobialantioxidantmarine natural productsphenolic compoundsphotoprotectiveskincareDrug DiscoveryUID/04292/2020 InSAICT-PAC/0019/2015-LISBOA-01-0145-FEDER-016405 POCI-01-0145-FEDER-029250The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed Carpomitra costata. The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five C. costata fractions (F1-F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC50 of 140.1 µg/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC50 of 7.2, 4.8 and 85.9 µg/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF-α and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of C. costata as a source of bioactive ingredients for further dermatological applications.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNSusano, PatríciaSilva, JoanaAlves, CelsoMartins, AliceGaspar, HelenaPinteus, SuseteMouga, TeresaGoettert, Márcia InesPetrovski, ŽeljkoBranco, Luís B.Pedrosa, Rui2022-01-29T06:05:16Z2021-02-282021-02-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/131848eng1660-3397PURE: 36441518https://doi.org/10.3390/md19030135info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:10:33Zoai:run.unl.pt:10362/131848Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:17.199942Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata
title Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata
spellingShingle Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata
Susano, Patrícia
algae
anti-enzymatic
anti-inflammatory
antimicrobial
antioxidant
marine natural products
phenolic compounds
photoprotective
skincare
Drug Discovery
title_short Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata
title_full Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata
title_fullStr Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata
title_full_unstemmed Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata
title_sort Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata
author Susano, Patrícia
author_facet Susano, Patrícia
Silva, Joana
Alves, Celso
Martins, Alice
Gaspar, Helena
Pinteus, Susete
Mouga, Teresa
Goettert, Márcia Ines
Petrovski, Željko
Branco, Luís B.
Pedrosa, Rui
author_role author
author2 Silva, Joana
Alves, Celso
Martins, Alice
Gaspar, Helena
Pinteus, Susete
Mouga, Teresa
Goettert, Márcia Ines
Petrovski, Željko
Branco, Luís B.
Pedrosa, Rui
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Susano, Patrícia
Silva, Joana
Alves, Celso
Martins, Alice
Gaspar, Helena
Pinteus, Susete
Mouga, Teresa
Goettert, Márcia Ines
Petrovski, Željko
Branco, Luís B.
Pedrosa, Rui
dc.subject.por.fl_str_mv algae
anti-enzymatic
anti-inflammatory
antimicrobial
antioxidant
marine natural products
phenolic compounds
photoprotective
skincare
Drug Discovery
topic algae
anti-enzymatic
anti-inflammatory
antimicrobial
antioxidant
marine natural products
phenolic compounds
photoprotective
skincare
Drug Discovery
description UID/04292/2020 InSAICT-PAC/0019/2015-LISBOA-01-0145-FEDER-016405 POCI-01-0145-FEDER-029250
publishDate 2021
dc.date.none.fl_str_mv 2021-02-28
2021-02-28T00:00:00Z
2022-01-29T06:05:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/131848
url http://hdl.handle.net/10362/131848
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1660-3397
PURE: 36441518
https://doi.org/10.3390/md19030135
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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