Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/163192 |
Resumo: | Funding Information: This work was supported by Reuma Nederland and Novartis. Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trialInflammationMagnetic Resonance ImagingSpondylitis, AnkylosingRheumatologyImmunology and AllergyImmunologyFunding Information: This work was supported by Reuma Nederland and Novartis. Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.Objectives To determine how much of the effect of vertebral corner inflammation on development of syndesmophytes is explained by vertebral corner fat deposition. Methods Patients with radiographic axial spondyloarthritis (r-axSpA) from the SIAS (Sensitive Imaging in Ankylosing Spondylitis) cohort and ASSERT (Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy) trial were assessed at T0, T1 (SIAS: 1 year; ASSERT: 24 weeks) and T2 (2 years). Syndesmophytes assessed in each vertebral corner by whole spine low-dose CT (SIAS) or spinal radiographs (ASSERT) at T0 and T2 were considered present if seen by two of two readers. Inflammation (T0) and fat deposition (T0 and T1) on MRI were present if seen by ≥2 of 3 readers (SIAS) or 2 of 2 readers (ASSERT). Vertebral corners showing fat deposition or a syndesmophyte at baseline were ignored. Mediation analysis was applied to determine what proportion of the total effect of inflammation on syndesmophyte formation could be explained via the path of intermediate fat deposition. Results Forty-nine SIAS patients (with 2667 vertebral corners) and 168 ASSERT patients (with 2918 vertebral corners) were analysed. The presence of inflammation at T0 increased the probability of a new syndesmophyte in the same vertebral corner at T2 by 9.3%. Of this total effect, 0.2% (2% (0.2 of 9.3) of the total effect) went via intermediate new fat deposition. In ASSERT, the total effect was 7.3%, of which 0.8% (10% of the total effect) went via new fat deposition. Conclusion In r-axSpA, vertebral corner inflammation may lead to syndesmophyte formation but in a minority of cases via visible fat deposition.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNStal, RosalindeRamiro, SofiaVan Der Heijde, DesiréeVan Gaalen, Floris A.Baraliakos, XenofonMachado, Pedro M.De Hooge, ManoukVan Den Berg, RosalineReijnierse, MoniqueBraun, JuergenLandewé, RobertSepriano, Alexandre2024-02-07T00:03:57Z2023-07-052023-07-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/163192eng2044-6055PURE: 82857171https://doi.org/10.1136/rmdopen-2023-003118info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:46:17Zoai:run.unl.pt:10362/163192Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:18.121348Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial |
| title |
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial |
| spellingShingle |
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial Stal, Rosalinde Inflammation Magnetic Resonance Imaging Spondylitis, Ankylosing Rheumatology Immunology and Allergy Immunology |
| title_short |
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial |
| title_full |
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial |
| title_fullStr |
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial |
| title_full_unstemmed |
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial |
| title_sort |
Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial |
| author |
Stal, Rosalinde |
| author_facet |
Stal, Rosalinde Ramiro, Sofia Van Der Heijde, Desirée Van Gaalen, Floris A. Baraliakos, Xenofon Machado, Pedro M. De Hooge, Manouk Van Den Berg, Rosaline Reijnierse, Monique Braun, Juergen Landewé, Robert Sepriano, Alexandre |
| author_role |
author |
| author2 |
Ramiro, Sofia Van Der Heijde, Desirée Van Gaalen, Floris A. Baraliakos, Xenofon Machado, Pedro M. De Hooge, Manouk Van Den Berg, Rosaline Reijnierse, Monique Braun, Juergen Landewé, Robert Sepriano, Alexandre |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Stal, Rosalinde Ramiro, Sofia Van Der Heijde, Desirée Van Gaalen, Floris A. Baraliakos, Xenofon Machado, Pedro M. De Hooge, Manouk Van Den Berg, Rosaline Reijnierse, Monique Braun, Juergen Landewé, Robert Sepriano, Alexandre |
| dc.subject.por.fl_str_mv |
Inflammation Magnetic Resonance Imaging Spondylitis, Ankylosing Rheumatology Immunology and Allergy Immunology |
| topic |
Inflammation Magnetic Resonance Imaging Spondylitis, Ankylosing Rheumatology Immunology and Allergy Immunology |
| description |
Funding Information: This work was supported by Reuma Nederland and Novartis. Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
| publishDate |
2023 |
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2023-07-05 2023-07-05T00:00:00Z 2024-02-07T00:03:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/163192 |
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http://hdl.handle.net/10362/163192 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2044-6055 PURE: 82857171 https://doi.org/10.1136/rmdopen-2023-003118 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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