Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review

Detalhes bibliográficos
Autor(a) principal: Modesto, Rita
Data de Publicação: 2022
Outros Autores: Estarreja, João, Silva, Inês, Rocha, João, Pinto, Rui, Mateus, Vanessa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/14656
Resumo: Project IPL/2021/PharmCAC_ESTeSL.
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oai_identifier_str oai:repositorio.ipl.pt:10400.21/14656
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network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic reviewColitisColorectal cancerPreclinical studiesDisease animal modelsAnimal experimentationIPL/2021/ PharmCAC_ESTeSLFCT_UIDB/05608/2020FCT_UIDP/05608/2020Project IPL/2021/PharmCAC_ESTeSL.FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.Animal models for colitis-associated colorectal cancer (CACC) represent an important tool to explore the mechanistic basis of cancer-related inflammation, providing important evidence that several inflammatory mediators play specific roles in the initiation and perpetuation of colitis and CACC. Although several original articles have been published describing the CACC model in rodents, there is no consensus about the induction method. This review aims to identify, summarize, compare, and discuss the chemical methods for the induction of CACC through the PRISMA methodology. Methods: We searched MEDLINE via the Pubmed platform for studies published through March 2021, using a highly sensitive search expression. The inclusion criteria were only original articles, articles where a chemically-induced animal model of CACC is described, preclinical studies in vivo with rodents, and articles published in English. Results: Chemically inducible models typically begin with the administration of a carcinogenic compound (as azoxymethane (AOM) or 1,2-dimethylhydrazine (DMH)), and inflammation is caused by repeated cycles of colitis-inducing agents (such as 2,4,6-trinitrobenzenesulfonic acid (TNBS) or dextran sulfate sodium (DSS)). The strains mostly used are C57BL/6 and Balb/c with 5–6 weeks. To characterize the preclinical model, the parameters more used include body weight, stool consistency, and morbidity, inflammatory biomarkers such as tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β, angiogenesis markers such as proliferating cell nuclear antigen (PCNA), a marker of proliferation Ki-67, and caspase 3, the presence of ulcers, thickness or hyperemia in the colon, and histological evaluation of inflammation. Conclusion: The AOM administration seems to be important to the CACC induction method since the carcinogenic effect is achieved with just one administration. DSS has been the more used inflammatory agent; however, the TNBS contribution should be more studied, since it allows a reliable, robust, and highly reproducible animal model of intestinal inflammation.RCIPLModesto, RitaEstarreja, JoãoSilva, InêsRocha, JoãoPinto, RuiMateus, Vanessa2022-05-23T12:11:42Z2022-052022-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14656engModesto R, Estarreja J, Silva IJ, Rocha J, Pinto R, Mateus V. Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review. J Clin Med. 2022;11(10):2739.10.3390/jcm11102739info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:11:08Zoai:repositorio.ipl.pt:10400.21/14656Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:25.659907Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review
title Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review
spellingShingle Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review
Modesto, Rita
Colitis
Colorectal cancer
Preclinical studies
Disease animal models
Animal experimentation
IPL/2021/ PharmCAC_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
title_short Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review
title_full Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review
title_fullStr Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review
title_full_unstemmed Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review
title_sort Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review
author Modesto, Rita
author_facet Modesto, Rita
Estarreja, João
Silva, Inês
Rocha, João
Pinto, Rui
Mateus, Vanessa
author_role author
author2 Estarreja, João
Silva, Inês
Rocha, João
Pinto, Rui
Mateus, Vanessa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Modesto, Rita
Estarreja, João
Silva, Inês
Rocha, João
Pinto, Rui
Mateus, Vanessa
dc.subject.por.fl_str_mv Colitis
Colorectal cancer
Preclinical studies
Disease animal models
Animal experimentation
IPL/2021/ PharmCAC_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
topic Colitis
Colorectal cancer
Preclinical studies
Disease animal models
Animal experimentation
IPL/2021/ PharmCAC_ESTeSL
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
description Project IPL/2021/PharmCAC_ESTeSL.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-23T12:11:42Z
2022-05
2022-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/14656
url http://hdl.handle.net/10400.21/14656
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Modesto R, Estarreja J, Silva IJ, Rocha J, Pinto R, Mateus V. Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: a systematic review. J Clin Med. 2022;11(10):2739.
10.3390/jcm11102739
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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