Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children

Detalhes bibliográficos
Autor(a) principal: Guiyedi, V.
Data de Publicação: 2007
Outros Autores: Chanseaud, Y., Fesel, C., Snounou, G., Rousselle, J.C., Lim, P., Koko, J., Namane, A., Cazenave, P.A., Kombila, M., Pied, S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/214
http://dx.doi.org/10.1371/journal.pone.0000389
Resumo: Hypergammaglobulinemia and polyclonal B-cell activation commonly occur in Plasmodium sp. infections. Some of the antibodies produced recognize self-components and are correlated with disease severity in P. falciparum malaria. However, it is not known whether some self-reactive antibodies produced during P. falciparum infection contribute to the events leading to cerebral malaria (CM). We show here a correlation between self-antibody responses to a human brain protein and high levels of circulating TNF alpha (TNFα), with the manifestation of CM in Gabonese children
id RCAP_e2386f6aef34e655cdf9782c74c86251
oai_identifier_str oai:arca.igc.gulbenkian.pt:10400.7/214
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese childrenImmunoglobulin G/immunologyMalaria, Cerebral/immunologyMalaria, Falciparum/immunologySpectrin/immunologyHypergammaglobulinemia and polyclonal B-cell activation commonly occur in Plasmodium sp. infections. Some of the antibodies produced recognize self-components and are correlated with disease severity in P. falciparum malaria. However, it is not known whether some self-reactive antibodies produced during P. falciparum infection contribute to the events leading to cerebral malaria (CM). We show here a correlation between self-antibody responses to a human brain protein and high levels of circulating TNF alpha (TNFα), with the manifestation of CM in Gabonese childrenPublic Library of ScienceARCAGuiyedi, V.Chanseaud, Y.Fesel, C.Snounou, G.Rousselle, J.C.Lim, P.Koko, J.Namane, A.Cazenave, P.A.Kombila, M.Pied, S.2011-05-18T16:29:42Z2007-042007-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/214http://dx.doi.org/10.1371/journal.pone.0000389eng1932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-21T14:21:38Zoai:arca.igc.gulbenkian.pt:10400.7/214Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-21T14:21:38Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children
title Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children
spellingShingle Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children
Guiyedi, V.
Immunoglobulin G/immunology
Malaria, Cerebral/immunology
Malaria, Falciparum/immunology
Spectrin/immunology
title_short Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children
title_full Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children
title_fullStr Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children
title_full_unstemmed Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children
title_sort Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children
author Guiyedi, V.
author_facet Guiyedi, V.
Chanseaud, Y.
Fesel, C.
Snounou, G.
Rousselle, J.C.
Lim, P.
Koko, J.
Namane, A.
Cazenave, P.A.
Kombila, M.
Pied, S.
author_role author
author2 Chanseaud, Y.
Fesel, C.
Snounou, G.
Rousselle, J.C.
Lim, P.
Koko, J.
Namane, A.
Cazenave, P.A.
Kombila, M.
Pied, S.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Guiyedi, V.
Chanseaud, Y.
Fesel, C.
Snounou, G.
Rousselle, J.C.
Lim, P.
Koko, J.
Namane, A.
Cazenave, P.A.
Kombila, M.
Pied, S.
dc.subject.por.fl_str_mv Immunoglobulin G/immunology
Malaria, Cerebral/immunology
Malaria, Falciparum/immunology
Spectrin/immunology
topic Immunoglobulin G/immunology
Malaria, Cerebral/immunology
Malaria, Falciparum/immunology
Spectrin/immunology
description Hypergammaglobulinemia and polyclonal B-cell activation commonly occur in Plasmodium sp. infections. Some of the antibodies produced recognize self-components and are correlated with disease severity in P. falciparum malaria. However, it is not known whether some self-reactive antibodies produced during P. falciparum infection contribute to the events leading to cerebral malaria (CM). We show here a correlation between self-antibody responses to a human brain protein and high levels of circulating TNF alpha (TNFα), with the manifestation of CM in Gabonese children
publishDate 2007
dc.date.none.fl_str_mv 2007-04
2007-04-01T00:00:00Z
2011-05-18T16:29:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/214
http://dx.doi.org/10.1371/journal.pone.0000389
url http://hdl.handle.net/10400.7/214
http://dx.doi.org/10.1371/journal.pone.0000389
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1932-6203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817549562351452160

Registros relacionados