p53 as the Focus of Gene Therapy: Past, Present and Future

Detalhes bibliográficos
Autor(a) principal: Valente, Joana
Data de Publicação: 2018
Outros Autores: Queiroz, João, Sousa, Fani
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/8178
Resumo: Several gene deviations can be responsible for triggering oncogenic processes. However, mutations in tumour suppressor genes are usually more associated to malignant diseases, with p53 being one of the most affected and studied element. p53 is implicated in a number of known cellular functions, including DNA damage repair, cell cycle arrest in G1/S and G2/M and apoptosis, being an interesting target for cancer treatment.
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spelling p53 as the Focus of Gene Therapy: Past, Present and FutureAntineoplastic AgentsCombined Modality TherapyGenetic TherapyGenetic VectorsHumansMutationNeoplasmsTransfectionTumor Suppressor Protein p53Several gene deviations can be responsible for triggering oncogenic processes. However, mutations in tumour suppressor genes are usually more associated to malignant diseases, with p53 being one of the most affected and studied element. p53 is implicated in a number of known cellular functions, including DNA damage repair, cell cycle arrest in G1/S and G2/M and apoptosis, being an interesting target for cancer treatment.Bentham Science PublishersuBibliorumValente, JoanaQueiroz, JoãoSousa, Fani2020-01-09T16:31:05Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/8178eng10.2174/1389450119666180115165447metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:47:58Zoai:ubibliorum.ubi.pt:10400.6/8178Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:48:34.302851Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv p53 as the Focus of Gene Therapy: Past, Present and Future
title p53 as the Focus of Gene Therapy: Past, Present and Future
spellingShingle p53 as the Focus of Gene Therapy: Past, Present and Future
Valente, Joana
Antineoplastic Agents
Combined Modality Therapy
Genetic Therapy
Genetic Vectors
Humans
Mutation
Neoplasms
Transfection
Tumor Suppressor Protein p53
title_short p53 as the Focus of Gene Therapy: Past, Present and Future
title_full p53 as the Focus of Gene Therapy: Past, Present and Future
title_fullStr p53 as the Focus of Gene Therapy: Past, Present and Future
title_full_unstemmed p53 as the Focus of Gene Therapy: Past, Present and Future
title_sort p53 as the Focus of Gene Therapy: Past, Present and Future
author Valente, Joana
author_facet Valente, Joana
Queiroz, João
Sousa, Fani
author_role author
author2 Queiroz, João
Sousa, Fani
author2_role author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Valente, Joana
Queiroz, João
Sousa, Fani
dc.subject.por.fl_str_mv Antineoplastic Agents
Combined Modality Therapy
Genetic Therapy
Genetic Vectors
Humans
Mutation
Neoplasms
Transfection
Tumor Suppressor Protein p53
topic Antineoplastic Agents
Combined Modality Therapy
Genetic Therapy
Genetic Vectors
Humans
Mutation
Neoplasms
Transfection
Tumor Suppressor Protein p53
description Several gene deviations can be responsible for triggering oncogenic processes. However, mutations in tumour suppressor genes are usually more associated to malignant diseases, with p53 being one of the most affected and studied element. p53 is implicated in a number of known cellular functions, including DNA damage repair, cell cycle arrest in G1/S and G2/M and apoptosis, being an interesting target for cancer treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2020-01-09T16:31:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/8178
url http://hdl.handle.net/10400.6/8178
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.2174/1389450119666180115165447
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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