Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/135510 |
Resumo: | Funding: The ADJUST study was supported by an investigatorinitiated grant from Medtronic. The company had no interference on study design or data analysis. All procedures were monitored by an external independent CRO. RR is supported by a grant from the Portuguese Foundation for Science and Technology (SFRH-BPD-110426-2015). The authors wish to thank the commitment of participants and care team at APDP e Diabetes Portugal. |
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Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapyDevicesEducationLifestylePsychological aspectsSelf-managementMedicine (miscellaneous)Endocrinology, Diabetes and MetabolismNutrition and DieteticsCardiology and Cardiovascular MedicineSDG 3 - Good Health and Well-beingFunding: The ADJUST study was supported by an investigatorinitiated grant from Medtronic. The company had no interference on study design or data analysis. All procedures were monitored by an external independent CRO. RR is supported by a grant from the Portuguese Foundation for Science and Technology (SFRH-BPD-110426-2015). The authors wish to thank the commitment of participants and care team at APDP e Diabetes Portugal.Background and aims: Blinded retrospective continuous glucose monitoring (rCGM) provides detailed information about real-life glycaemic profile. In persons with type 2 diabetes without adequate glycaemic control, the structured introduction of rCGM may be beneficial to sustain improvements in diabetes management. Methods and results: 102 individuals with insulin-treated type 2 diabetes, age less than 66 years old and HbA1c >7.5%, were recruited. Participants performed a 7-day blinded rCGM (iPro2) every four months for one year. Biochemical, anthropometric, and rCGM data was collected. Participants' and healthcare professionals’ perceptions were assessed. 90 participants completed the protocol. HbA1c was 9.1 ± 0.1% one year prior to enrolment and 9.4 ± 0.1% at enrolment (p < 0.01). With the rCGM-based intervention, a decrease in HbA1c was achieved at 4 months (8.4 ± 0.1%, p < 0.0001), and 12 months (8.1 ± 0.1%, p < 0.0001). A significant increase in time-in-range was observed (50.8 ± 2.4 at baseline vs 61.5 ± 2.2% at 12 months, for 70–180 mg/dL, p < 0.001), with no difference in exposure time to hypoglycaemia. After 12 months, there was an increase in self-reported diabetes treatment satisfaction (p < 0.05). Conclusion: In persons with type 2 diabetes and poor metabolic control, specific data from blinded rCGM informed therapeutic changes and referral to targeted education consultations on nutrition and insulin administration technique. Therapeutic changes were made more frequently and targeted to changes in medication dose, timing, and/or type, as well as to lifestyle. Together, these brought significant improvements in clinical outcomes, effective shared decision-making, and satisfaction with treatment. Registration number: NCT04141111.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNRibeiro, Rogério TavaresAndrade, RitaNascimento do Ó, DulceLopes, Ana FilipaRaposo, João Filipe2022-03-30T11:26:41Z2021-04-092021-04-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/135510eng0939-4753PURE: 28429015https://doi.org/10.1016/j.numecd.2020.12.024info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:13:48Zoai:run.unl.pt:10362/135510Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:25.092492Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapy |
| title |
Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapy |
| spellingShingle |
Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapy Ribeiro, Rogério Tavares Devices Education Lifestyle Psychological aspects Self-management Medicine (miscellaneous) Endocrinology, Diabetes and Metabolism Nutrition and Dietetics Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| title_short |
Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapy |
| title_full |
Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapy |
| title_fullStr |
Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapy |
| title_full_unstemmed |
Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapy |
| title_sort |
Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapy |
| author |
Ribeiro, Rogério Tavares |
| author_facet |
Ribeiro, Rogério Tavares Andrade, Rita Nascimento do Ó, Dulce Lopes, Ana Filipa Raposo, João Filipe |
| author_role |
author |
| author2 |
Andrade, Rita Nascimento do Ó, Dulce Lopes, Ana Filipa Raposo, João Filipe |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
| dc.contributor.author.fl_str_mv |
Ribeiro, Rogério Tavares Andrade, Rita Nascimento do Ó, Dulce Lopes, Ana Filipa Raposo, João Filipe |
| dc.subject.por.fl_str_mv |
Devices Education Lifestyle Psychological aspects Self-management Medicine (miscellaneous) Endocrinology, Diabetes and Metabolism Nutrition and Dietetics Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| topic |
Devices Education Lifestyle Psychological aspects Self-management Medicine (miscellaneous) Endocrinology, Diabetes and Metabolism Nutrition and Dietetics Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| description |
Funding: The ADJUST study was supported by an investigatorinitiated grant from Medtronic. The company had no interference on study design or data analysis. All procedures were monitored by an external independent CRO. RR is supported by a grant from the Portuguese Foundation for Science and Technology (SFRH-BPD-110426-2015). The authors wish to thank the commitment of participants and care team at APDP e Diabetes Portugal. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-04-09 2021-04-09T00:00:00Z 2022-03-30T11:26:41Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/135510 |
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http://hdl.handle.net/10362/135510 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0939-4753 PURE: 28429015 https://doi.org/10.1016/j.numecd.2020.12.024 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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