Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications

Detalhes bibliográficos
Autor(a) principal: Carrelo, Henrique
Data de Publicação: 2023
Outros Autores: Escoval, André R., Vieira, Tânia, Jiménez-Rosado, Mercedes, Silva, Jorge Carvalho, Romero, Alberto, Soares, Paula Isabel P., Borges, João Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/162710
Resumo: This work is funded by National Funds through the FCT—Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. This study was also financially supported by MCIN/AEI/10.13039/501100011033///FEDER, UE, through project PID2021-124294OB-C21. Publisher Copyright: © 2023 by the authors.
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spelling Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia ApplicationshydrogelsmicroparticlesPluronicrheologyBioengineeringBiomaterialsOrganic ChemistryPolymers and PlasticsSDG 3 - Good Health and Well-beingThis work is funded by National Funds through the FCT—Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. This study was also financially supported by MCIN/AEI/10.13039/501100011033///FEDER, UE, through project PID2021-124294OB-C21. Publisher Copyright: © 2023 by the authors.Cancer is a disease that continues to greatly impact our society. Developing new and more personalized treatment options is crucial to decreasing the cancer burden. In this study, we combined magnetic polysaccharide microparticles with a Pluronic thermoresponsive hydrogel to develop a multifunctional, injectable drug delivery system (DDS) for magnetic hyperthermia applications. Gellan gum and alginate microparticles were loaded with superparamagnetic iron oxide nanoparticles (SPIONs) with and without coating. The magnetic microparticles’ registered temperature increases up to 4 °C upon the application of an alternating magnetic field. These magnetic microparticles were mixed with drug-loaded microparticles, and, subsequently, this mixture was embedded within a Pluronic thermoresponsive hydrogel that is capable of being in the gel state at 37 °C. The proposed DDS was capable of slowly releasing methylene blue, used as a model drug, for up to 9 days. The developed hydrogel/microparticle system had a smaller rate of drug release compared with microparticles alone. This system proved to be a potential thermoresponsive DDS suitable for magnetic hyperthermia applications, thus enabling a synergistic treatment for cancer.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisDF – Departamento de FísicaRUNCarrelo, HenriqueEscoval, André R.Vieira, TâniaJiménez-Rosado, MercedesSilva, Jorge CarvalhoRomero, AlbertoSoares, Paula Isabel P.Borges, João Paulo2024-01-24T17:02:12Z2023-12-152023-12-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20application/pdfhttp://hdl.handle.net/10362/162710eng2310-2861PURE: 81996763https://doi.org/10.3390/gels9120982info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:45:40Zoai:run.unl.pt:10362/162710Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:02.194459Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
title Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
spellingShingle Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
Carrelo, Henrique
hydrogels
microparticles
Pluronic
rheology
Bioengineering
Biomaterials
Organic Chemistry
Polymers and Plastics
SDG 3 - Good Health and Well-being
title_short Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
title_full Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
title_fullStr Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
title_full_unstemmed Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
title_sort Injectable Thermoresponsive Microparticle/Hydrogel System with Superparamagnetic Nanoparticles for Drug Release and Magnetic Hyperthermia Applications
author Carrelo, Henrique
author_facet Carrelo, Henrique
Escoval, André R.
Vieira, Tânia
Jiménez-Rosado, Mercedes
Silva, Jorge Carvalho
Romero, Alberto
Soares, Paula Isabel P.
Borges, João Paulo
author_role author
author2 Escoval, André R.
Vieira, Tânia
Jiménez-Rosado, Mercedes
Silva, Jorge Carvalho
Romero, Alberto
Soares, Paula Isabel P.
Borges, João Paulo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
DF – Departamento de Física
RUN
dc.contributor.author.fl_str_mv Carrelo, Henrique
Escoval, André R.
Vieira, Tânia
Jiménez-Rosado, Mercedes
Silva, Jorge Carvalho
Romero, Alberto
Soares, Paula Isabel P.
Borges, João Paulo
dc.subject.por.fl_str_mv hydrogels
microparticles
Pluronic
rheology
Bioengineering
Biomaterials
Organic Chemistry
Polymers and Plastics
SDG 3 - Good Health and Well-being
topic hydrogels
microparticles
Pluronic
rheology
Bioengineering
Biomaterials
Organic Chemistry
Polymers and Plastics
SDG 3 - Good Health and Well-being
description This work is funded by National Funds through the FCT—Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/50025/2020-2023 and LA/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. This study was also financially supported by MCIN/AEI/10.13039/501100011033///FEDER, UE, through project PID2021-124294OB-C21. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-15
2023-12-15T00:00:00Z
2024-01-24T17:02:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/162710
url http://hdl.handle.net/10362/162710
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2310-2861
PURE: 81996763
https://doi.org/10.3390/gels9120982
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 20
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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