The role of ionic liquids in the pharmaceutical field: an overview of relevant applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/30886 |
Resumo: | Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems. |
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The role of ionic liquids in the pharmaceutical field: an overview of relevant applicationsActive pharmaceutical ingredientsDrug delivery systemsFormulationsIonic liquidsSolubilityPermeabilitySolubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.MDPI2021-03-16T11:15:36Z2020-11-05T00:00:00Z2020-11-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/30886eng1661-659610.3390/ijms21218298Pedro, Sónia N.Freire, Carmen S. R.Silvestre, Armando J. D.Freire, Mara G.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:59:41Zoai:ria.ua.pt:10773/30886Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:02:52.609138Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The role of ionic liquids in the pharmaceutical field: an overview of relevant applications |
title |
The role of ionic liquids in the pharmaceutical field: an overview of relevant applications |
spellingShingle |
The role of ionic liquids in the pharmaceutical field: an overview of relevant applications Pedro, Sónia N. Active pharmaceutical ingredients Drug delivery systems Formulations Ionic liquids Solubility Permeability |
title_short |
The role of ionic liquids in the pharmaceutical field: an overview of relevant applications |
title_full |
The role of ionic liquids in the pharmaceutical field: an overview of relevant applications |
title_fullStr |
The role of ionic liquids in the pharmaceutical field: an overview of relevant applications |
title_full_unstemmed |
The role of ionic liquids in the pharmaceutical field: an overview of relevant applications |
title_sort |
The role of ionic liquids in the pharmaceutical field: an overview of relevant applications |
author |
Pedro, Sónia N. |
author_facet |
Pedro, Sónia N. Freire, Carmen S. R. Silvestre, Armando J. D. Freire, Mara G. |
author_role |
author |
author2 |
Freire, Carmen S. R. Silvestre, Armando J. D. Freire, Mara G. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Pedro, Sónia N. Freire, Carmen S. R. Silvestre, Armando J. D. Freire, Mara G. |
dc.subject.por.fl_str_mv |
Active pharmaceutical ingredients Drug delivery systems Formulations Ionic liquids Solubility Permeability |
topic |
Active pharmaceutical ingredients Drug delivery systems Formulations Ionic liquids Solubility Permeability |
description |
Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-05T00:00:00Z 2020-11-05 2021-03-16T11:15:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/30886 |
url |
http://hdl.handle.net/10773/30886 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1661-6596 10.3390/ijms21218298 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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