Aspergillus collected in specific indoor settings: their molecular identification and susceptibility pattern

Detalhes bibliográficos
Autor(a) principal: Simões, Daniela
Data de Publicação: 2019
Outros Autores: Aranha Caetano, Liliana, Veríssimo, Cristina, Viegas, Carla, Sabino, Raquel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6473
Resumo: Exposure to Aspergillus conidia is an increased risk factor for the development of respiratory symptoms. The emergence of azole resistance in Aspergillus fumigatus is a major concern for the scientific community. The aim of this study was to perform the molecular identification of Aspergillus species collected from different occupational and non-occupational indoor settings and to study the azole susceptibility profile of the collected Fumigati isolates. The selected Aspergillus isolates were identified as belonging to the sections Fumigati, Nigri Versicolores, Terrei, Clavati and Nidulantes. All the Aspergillus fumigatus were screened for azole resistance using an agar media supplemented with itraconazole, voriconazole and posaconazole. None of the tested isolates showed resistance to those azoles. Knowledge of Aspergillus epidemiology in specific indoor environments allows a better risk characterization regarding Aspergillus burden. This study allowed the analysis of the molecular epidemiology and the determination of the susceptibility pattern of Aspergillus section Fumigati found in the studied indoor settings.
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spelling Aspergillus collected in specific indoor settings: their molecular identification and susceptibility patternAspergillusOccupational ExposureMolecular EpidemiologyAntifungal SusceptibilityIndoor AirInfecções RespiratóriasExposure to Aspergillus conidia is an increased risk factor for the development of respiratory symptoms. The emergence of azole resistance in Aspergillus fumigatus is a major concern for the scientific community. The aim of this study was to perform the molecular identification of Aspergillus species collected from different occupational and non-occupational indoor settings and to study the azole susceptibility profile of the collected Fumigati isolates. The selected Aspergillus isolates were identified as belonging to the sections Fumigati, Nigri Versicolores, Terrei, Clavati and Nidulantes. All the Aspergillus fumigatus were screened for azole resistance using an agar media supplemented with itraconazole, voriconazole and posaconazole. None of the tested isolates showed resistance to those azoles. Knowledge of Aspergillus epidemiology in specific indoor environments allows a better risk characterization regarding Aspergillus burden. This study allowed the analysis of the molecular epidemiology and the determination of the susceptibility pattern of Aspergillus section Fumigati found in the studied indoor settings.This work was supported by FCT – Fundação para Ciência e Tecnologia under the project EXPOsE – Establishing protocols to assess occupational exposure to microbiota in clinical settings (02/SAICT/2016 – Grant nº 23222).Taylor & Francis/ International Federation of Environmental HealthRepositório Científico do Instituto Nacional de SaúdeSimões, DanielaAranha Caetano, LilianaVeríssimo, CristinaViegas, CarlaSabino, Raquel2020-04-21T18:55:30Z2019-08-132019-08-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6473engInt J Environ Health Res. 2019 Aug 13;1-10. doi: 10.1080/09603123.2019.1650903. Online ahead of print0960-312310.1080/09603123.2019.1650903info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:32Zoai:repositorio.insa.pt:10400.18/6473Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:18.042545Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Aspergillus collected in specific indoor settings: their molecular identification and susceptibility pattern
title Aspergillus collected in specific indoor settings: their molecular identification and susceptibility pattern
spellingShingle Aspergillus collected in specific indoor settings: their molecular identification and susceptibility pattern
Simões, Daniela
Aspergillus
Occupational Exposure
Molecular Epidemiology
Antifungal Susceptibility
Indoor Air
Infecções Respiratórias
title_short Aspergillus collected in specific indoor settings: their molecular identification and susceptibility pattern
title_full Aspergillus collected in specific indoor settings: their molecular identification and susceptibility pattern
title_fullStr Aspergillus collected in specific indoor settings: their molecular identification and susceptibility pattern
title_full_unstemmed Aspergillus collected in specific indoor settings: their molecular identification and susceptibility pattern
title_sort Aspergillus collected in specific indoor settings: their molecular identification and susceptibility pattern
author Simões, Daniela
author_facet Simões, Daniela
Aranha Caetano, Liliana
Veríssimo, Cristina
Viegas, Carla
Sabino, Raquel
author_role author
author2 Aranha Caetano, Liliana
Veríssimo, Cristina
Viegas, Carla
Sabino, Raquel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Simões, Daniela
Aranha Caetano, Liliana
Veríssimo, Cristina
Viegas, Carla
Sabino, Raquel
dc.subject.por.fl_str_mv Aspergillus
Occupational Exposure
Molecular Epidemiology
Antifungal Susceptibility
Indoor Air
Infecções Respiratórias
topic Aspergillus
Occupational Exposure
Molecular Epidemiology
Antifungal Susceptibility
Indoor Air
Infecções Respiratórias
description Exposure to Aspergillus conidia is an increased risk factor for the development of respiratory symptoms. The emergence of azole resistance in Aspergillus fumigatus is a major concern for the scientific community. The aim of this study was to perform the molecular identification of Aspergillus species collected from different occupational and non-occupational indoor settings and to study the azole susceptibility profile of the collected Fumigati isolates. The selected Aspergillus isolates were identified as belonging to the sections Fumigati, Nigri Versicolores, Terrei, Clavati and Nidulantes. All the Aspergillus fumigatus were screened for azole resistance using an agar media supplemented with itraconazole, voriconazole and posaconazole. None of the tested isolates showed resistance to those azoles. Knowledge of Aspergillus epidemiology in specific indoor environments allows a better risk characterization regarding Aspergillus burden. This study allowed the analysis of the molecular epidemiology and the determination of the susceptibility pattern of Aspergillus section Fumigati found in the studied indoor settings.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-13
2019-08-13T00:00:00Z
2020-04-21T18:55:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6473
url http://hdl.handle.net/10400.18/6473
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Environ Health Res. 2019 Aug 13;1-10. doi: 10.1080/09603123.2019.1650903. Online ahead of print
0960-3123
10.1080/09603123.2019.1650903
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis/ International Federation of Environmental Health
publisher.none.fl_str_mv Taylor & Francis/ International Federation of Environmental Health
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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