Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity

Detalhes bibliográficos
Autor(a) principal: Brandão, Pedro
Data de Publicação: 2021
Outros Autores: Marques, Carolina S., Carreiro, Elisabete P., Pineiro, Marta, Burke, Anthony J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10174/31433
https://doi.org/10.1002/tcr.202000167
Resumo: Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and even, under certain conditions, ring-opening reactions occur that leads to other heterocyclic compounds. Over the past few years, new methodologies have been described for the application of this important and easily available starting material in MCRs. In this review, we explore these novelties, displaying them according to the structure of the final products obtained.
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spelling Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversityisatinspirooxindolesmulticomponent reactionssustainabilitycatalysisoxindoleMulticomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and even, under certain conditions, ring-opening reactions occur that leads to other heterocyclic compounds. Over the past few years, new methodologies have been described for the application of this important and easily available starting material in MCRs. In this review, we explore these novelties, displaying them according to the structure of the final products obtained.The Chemical Society of Japan & Wiley-VCH GmbH2022-03-23T16:16:40Z2022-03-232021-02-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/31433http://hdl.handle.net/10174/31433https://doi.org/10.1002/tcr.202000167enghttps://onlinelibrary.wiley.com/doi/10.1002/tcr.202000167ndcarolsmarq@uevora.ptbetepc@uevora.ptndajb@uevora.pt307Brandão, PedroMarques, Carolina S.Carreiro, Elisabete P.Pineiro, MartaBurke, Anthony J.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-08T04:45:11ZPortal AgregadorONG
dc.title.none.fl_str_mv Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity
title Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity
spellingShingle Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity
Brandão, Pedro
isatin
spirooxindoles
multicomponent reactions
sustainability
catalysis
oxindole
title_short Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity
title_full Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity
title_fullStr Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity
title_full_unstemmed Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity
title_sort Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity
author Brandão, Pedro
author_facet Brandão, Pedro
Marques, Carolina S.
Carreiro, Elisabete P.
Pineiro, Marta
Burke, Anthony J.
author_role author
author2 Marques, Carolina S.
Carreiro, Elisabete P.
Pineiro, Marta
Burke, Anthony J.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Brandão, Pedro
Marques, Carolina S.
Carreiro, Elisabete P.
Pineiro, Marta
Burke, Anthony J.
dc.subject.por.fl_str_mv isatin
spirooxindoles
multicomponent reactions
sustainability
catalysis
oxindole
topic isatin
spirooxindoles
multicomponent reactions
sustainability
catalysis
oxindole
description Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and even, under certain conditions, ring-opening reactions occur that leads to other heterocyclic compounds. Over the past few years, new methodologies have been described for the application of this important and easily available starting material in MCRs. In this review, we explore these novelties, displaying them according to the structure of the final products obtained.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-14T00:00:00Z
2022-03-23T16:16:40Z
2022-03-23
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10174/31433
http://hdl.handle.net/10174/31433
https://doi.org/10.1002/tcr.202000167
url http://hdl.handle.net/10174/31433
https://doi.org/10.1002/tcr.202000167
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://onlinelibrary.wiley.com/doi/10.1002/tcr.202000167
nd
carolsmarq@uevora.pt
betepc@uevora.pt
nd
ajb@uevora.pt
307
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The Chemical Society of Japan & Wiley-VCH GmbH
publisher.none.fl_str_mv The Chemical Society of Japan & Wiley-VCH GmbH
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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