Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/11249 |
Resumo: | It has recently been shown (Vaz, W.L.C., E.C.C. Melo, and T.E. ThomPson. 1989. Biophys. J. 56:869-875; 1990. Biophys. J. 58:273-275) that in lipid bilayer membranes in which ordered and disordered phases coexist, the ordered phase can form a two-dimensional reticular structure that subdivides the coexisting disordered phase into a disconnected domain structure. Here we consider theoretically the yields of bimolecular reactions between membrane-localized reactants, when both the reactants and products are confined to the disordered phase. It is shown that compartmentalization of reactants in disconnected domains can lead to significant reductions in reaction yields. The reduction in yield was calculated for classical bimolecular processes and for enzyme-catalyzed reactions. These ideas can be used to explain certain experimental observations. |
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7160 |
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Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes2-phase phosphatidylcholine bilayerFluid-phase connectivityTranslational diffusionLateral diffusionMitochondrial2-componentTransitionsMobilityModelIt has recently been shown (Vaz, W.L.C., E.C.C. Melo, and T.E. ThomPson. 1989. Biophys. J. 56:869-875; 1990. Biophys. J. 58:273-275) that in lipid bilayer membranes in which ordered and disordered phases coexist, the ordered phase can form a two-dimensional reticular structure that subdivides the coexisting disordered phase into a disconnected domain structure. Here we consider theoretically the yields of bimolecular reactions between membrane-localized reactants, when both the reactants and products are confined to the disordered phase. It is shown that compartmentalization of reactants in disconnected domains can lead to significant reductions in reaction yields. The reduction in yield was calculated for classical bimolecular processes and for enzyme-catalyzed reactions. These ideas can be used to explain certain experimental observations.NIGMS NIH HHS [GM-23573, GM-14628]Biophysical SocietySapientiaMelo, E. C. C.Lourtie, I. M. G.Sankaram, M. B.Thompson, T. E.Vaz, Winchil2018-12-07T14:52:53Z1992-121992-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11249eng0006-349510.1016/S0006-3495(92)81735-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:23:00Zoai:sapientia.ualg.pt:10400.1/11249Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:02:44.965898Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes |
title |
Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes |
spellingShingle |
Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes Melo, E. C. C. 2-phase phosphatidylcholine bilayer Fluid-phase connectivity Translational diffusion Lateral diffusion Mitochondrial 2-component Transitions Mobility Model |
title_short |
Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes |
title_full |
Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes |
title_fullStr |
Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes |
title_full_unstemmed |
Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes |
title_sort |
Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes |
author |
Melo, E. C. C. |
author_facet |
Melo, E. C. C. Lourtie, I. M. G. Sankaram, M. B. Thompson, T. E. Vaz, Winchil |
author_role |
author |
author2 |
Lourtie, I. M. G. Sankaram, M. B. Thompson, T. E. Vaz, Winchil |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Melo, E. C. C. Lourtie, I. M. G. Sankaram, M. B. Thompson, T. E. Vaz, Winchil |
dc.subject.por.fl_str_mv |
2-phase phosphatidylcholine bilayer Fluid-phase connectivity Translational diffusion Lateral diffusion Mitochondrial 2-component Transitions Mobility Model |
topic |
2-phase phosphatidylcholine bilayer Fluid-phase connectivity Translational diffusion Lateral diffusion Mitochondrial 2-component Transitions Mobility Model |
description |
It has recently been shown (Vaz, W.L.C., E.C.C. Melo, and T.E. ThomPson. 1989. Biophys. J. 56:869-875; 1990. Biophys. J. 58:273-275) that in lipid bilayer membranes in which ordered and disordered phases coexist, the ordered phase can form a two-dimensional reticular structure that subdivides the coexisting disordered phase into a disconnected domain structure. Here we consider theoretically the yields of bimolecular reactions between membrane-localized reactants, when both the reactants and products are confined to the disordered phase. It is shown that compartmentalization of reactants in disconnected domains can lead to significant reductions in reaction yields. The reduction in yield was calculated for classical bimolecular processes and for enzyme-catalyzed reactions. These ideas can be used to explain certain experimental observations. |
publishDate |
1992 |
dc.date.none.fl_str_mv |
1992-12 1992-12-01T00:00:00Z 2018-12-07T14:52:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/11249 |
url |
http://hdl.handle.net/10400.1/11249 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0006-3495 10.1016/S0006-3495(92)81735-6 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Biophysical Society |
publisher.none.fl_str_mv |
Biophysical Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133261699481600 |