Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations

• Autor(a) principal: Thorpe, Harry A
• Data de Publicação: 2022
• Outros Autores: Tourrette, Elise, Yahara, Koji, Vale, Filipa F., Liu, Siqi, Oleastro, Mónica, Alarcon, Teresa, Perets, Tsachi-Tsadok, Latifi-Navid, Saeid, Yamaoka, Yoshio, Martinez-Gonzalez, Beatriz, Karayiannis, Ioannis, Karamitros, Timokratis, Sgouras, Dionyssios N., Elamin, Wael, Pascoe, Ben, Sheppard, Samuel K., Ronkainen, Jukka, Aro, Pertti, Engstrand, Lars, Agreus, Lars, Suerbaum, Sebastian, Thorell, Kaisa, Falush, Daniel
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10451/59116

Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori from East Asia, which have undergone little admixture, have accumulated many more non-synonymous mutations than African strains. European and Middle Eastern bacteria have elevated African ancestry at the sites of these mutations, implying selection to remove them during admixture. Simulations show that population fitness can be restored after bottlenecks by migration and subsequent admixture of small numbers of bacteria from non-bottlenecked populations. We conclude that recent spread of African DNA has been driven by deleterious mutations accumulated during the original out-of-Africa bottleneck.