Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes

Detalhes bibliográficos
Autor(a) principal: Zhu, Ruixin
Data de Publicação: 2022
Outros Autores: Craciun, Ionut, Bernhards-Werge, Jan, Jalo, Elli, Poppitt, Sally D, Silvestre, Marta P, Huttunen-Lenz, Maija, McNarry, Melitta A, Stratton, Gareth, Handjiev, Svetoslav, Handjieva-Darlenska, Teodora, Navas-Carretero, Santiago, Sundvall, Jouko, Adam, Tanja C, Drummen, Mathijs, Simpson, Elizabeth J, Macdonald, Ian A, Brand-Miller, Jennie, Muirhead, Roslyn, Lam, Tony, Vestentoft, Pia S, Færch, Kristine, Martinez, J Alfredo, Fogelholm, Mikael, Raben, Anne
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/141562
Resumo: Funding: Open Access funding provided by University of Helsinki including Helsinki University Central Hospital. This research was supported by the EU Seventh Framework Programme (FP7; 2007– 2013) (grant no. 312057); National Health and Medical Research Council (EU Collaborative Grant AUS 8, ID 1067711); Glycemic Diabetologia Index Foundation Australia through royalties to the University of Sydney; Health Research Council of New Zealand (grant no. 14/191) and University of Auckland Faculty Research Development Fund; Cambridge Weight Plan, which donated all products for the 8 week weight loss period; Danish Agriculture & Food Council; Danish Meat Research Institute; National Institute for Health Research Biomedical Research Centre (NIHR BRC) (UK); Biotechnology and Biological Sciences Research Council (BBSRC) (UK); Engineering and Physical Sciences Research Council (EPSRC) (UK); Nutritics (Dublin), which donated all dietary analysis software used by the University of Nottingham; Juho Vainio Foundation (Finland); Academy of Finland (grant nos 272376, 314383, 266286 and 314135); Finnish Medical Foundation; Gyllenberg Foundation (Finland); Novo Nordisk Foundation; Finnish Diabetes Research Foundation; University of Helsinki; Government Research Funds for Helsinki University Hospital; Jenny and Antti Wihuri Foundation (Finland); Emil Aaltonen Foundation (Finland); and China Scholarship Council. The funders were not involved in the design of the study, the collection, analysis and interpretation of the data or writing of the report and did not impose any restrictions regarding the publication of the report.
id RCAP_f402088cbda292549517c2b218e369ec
oai_identifier_str oai:run.unl.pt:10362/141562
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetesresults from the diabetes prevention study PREVIEWCardiovascular diseaseMenMiddle-aged peopleObesityOlder peopleWeight lossWeight loss maintenanceWomenYoung peopleSDG 3 - Good Health and Well-beingFunding: Open Access funding provided by University of Helsinki including Helsinki University Central Hospital. This research was supported by the EU Seventh Framework Programme (FP7; 2007– 2013) (grant no. 312057); National Health and Medical Research Council (EU Collaborative Grant AUS 8, ID 1067711); Glycemic Diabetologia Index Foundation Australia through royalties to the University of Sydney; Health Research Council of New Zealand (grant no. 14/191) and University of Auckland Faculty Research Development Fund; Cambridge Weight Plan, which donated all products for the 8 week weight loss period; Danish Agriculture & Food Council; Danish Meat Research Institute; National Institute for Health Research Biomedical Research Centre (NIHR BRC) (UK); Biotechnology and Biological Sciences Research Council (BBSRC) (UK); Engineering and Physical Sciences Research Council (EPSRC) (UK); Nutritics (Dublin), which donated all dietary analysis software used by the University of Nottingham; Juho Vainio Foundation (Finland); Academy of Finland (grant nos 272376, 314383, 266286 and 314135); Finnish Medical Foundation; Gyllenberg Foundation (Finland); Novo Nordisk Foundation; Finnish Diabetes Research Foundation; University of Helsinki; Government Research Funds for Helsinki University Hospital; Jenny and Antti Wihuri Foundation (Finland); Emil Aaltonen Foundation (Finland); and China Scholarship Council. The funders were not involved in the design of the study, the collection, analysis and interpretation of the data or writing of the report and did not impose any restrictions regarding the publication of the report.AIMS/HYPOTHESIS: Lifestyle interventions are the first-line treatment option for body weight and cardiometabolic health management. However, whether age groups or women and men respond differently to lifestyle interventions is under debate. We aimed to examine age- and sex-specific effects of a low-energy diet (LED) followed by a long-term lifestyle intervention on body weight, body composition and cardiometabolic health markers in adults with prediabetes (i.e. impaired fasting glucose and/or impaired glucose tolerance). METHODS: This observational study used longitudinal data from 2223 overweight participants with prediabetes in the multicentre diabetes prevention study PREVIEW. The participants underwent a LED-induced rapid weight loss (WL) period followed by a 3 year lifestyle-based weight maintenance (WM) intervention. Changes in outcomes of interest in prespecified age (younger: 25-45 years; middle-aged: 46-54 years; older: 55-70 years) or sex (women and men) groups were compared. RESULTS: In total, 783 younger, 319 middle-aged and 1121 older adults and 1503 women and 720 men were included in the analysis. In the available case and complete case analyses, multivariable-adjusted linear mixed models showed that younger and older adults had similar weight loss after the LED, whereas older adults had greater sustained weight loss after the WM intervention (adjusted difference for older vs younger adults -1.25% [95% CI -1.92, -0.58], p<0.001). After the WM intervention, older adults lost more fat-free mass and bone mass and had smaller improvements in 2 h plasma glucose (adjusted difference for older vs younger adults 0.65 mmol/l [95% CI 0.50, 0.80], p<0.001) and systolic blood pressure (adjusted difference for older vs younger adults 2.57 mmHg [95% CI 1.37, 3.77], p<0.001) than younger adults. Older adults had smaller decreases in fasting and 2 h glucose, HbA 1c and systolic blood pressure after the WM intervention than middle-aged adults. In the complete case analysis, the above-mentioned differences between middle-aged and older adults disappeared, but the direction of the effect size did not change. After the WL period, compared with men, women had less weight loss (adjusted difference for women vs men 1.78% [95% CI 1.12, 2.43], p<0.001) with greater fat-free mass and bone mass loss and smaller improvements in HbA 1c, LDL-cholesterol and diastolic blood pressure. After the WM intervention, women had greater fat-free mass and bone mass loss and smaller improvements in HbA 1c and LDL-cholesterol, while they had greater improvements in fasting glucose, triacylglycerol (adjusted difference for women vs men -0.08 mmol/l [-0.11, -0.04], p<0.001) and HDL-cholesterol. CONCLUSIONS/INTERPRETATION: Older adults benefited less from a lifestyle intervention in relation to body composition and cardiometabolic health markers than younger adults, despite greater sustained weight loss. Women benefited less from a LED followed by a lifestyle intervention in relation to body weight and body composition than men. Future interventions targeting older adults or women should take prevention of fat-free mass and bone mass loss into consideration. CLINICAL TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT01777893.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNZhu, RuixinCraciun, IonutBernhards-Werge, JanJalo, ElliPoppitt, Sally DSilvestre, Marta PHuttunen-Lenz, MaijaMcNarry, Melitta AStratton, GarethHandjiev, SvetoslavHandjieva-Darlenska, TeodoraNavas-Carretero, SantiagoSundvall, JoukoAdam, Tanja CDrummen, MathijsSimpson, Elizabeth JMacdonald, Ian ABrand-Miller, JennieMuirhead, RoslynLam, TonyVestentoft, Pia SFærch, KristineMartinez, J AlfredoFogelholm, MikaelRaben, Anne2022-07-07T22:27:56Z2022-082022-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/141562eng0012-186XPURE: 45210721https://doi.org/10.1007/s00125-022-05716-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:18:57Zoai:run.unl.pt:10362/141562Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:01.925772Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes
results from the diabetes prevention study PREVIEW
title Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes
spellingShingle Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes
Zhu, Ruixin
Cardiovascular disease
Men
Middle-aged people
Obesity
Older people
Weight loss
Weight loss maintenance
Women
Young people
SDG 3 - Good Health and Well-being
title_short Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes
title_full Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes
title_fullStr Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes
title_full_unstemmed Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes
title_sort Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes
author Zhu, Ruixin
author_facet Zhu, Ruixin
Craciun, Ionut
Bernhards-Werge, Jan
Jalo, Elli
Poppitt, Sally D
Silvestre, Marta P
Huttunen-Lenz, Maija
McNarry, Melitta A
Stratton, Gareth
Handjiev, Svetoslav
Handjieva-Darlenska, Teodora
Navas-Carretero, Santiago
Sundvall, Jouko
Adam, Tanja C
Drummen, Mathijs
Simpson, Elizabeth J
Macdonald, Ian A
Brand-Miller, Jennie
Muirhead, Roslyn
Lam, Tony
Vestentoft, Pia S
Færch, Kristine
Martinez, J Alfredo
Fogelholm, Mikael
Raben, Anne
author_role author
author2 Craciun, Ionut
Bernhards-Werge, Jan
Jalo, Elli
Poppitt, Sally D
Silvestre, Marta P
Huttunen-Lenz, Maija
McNarry, Melitta A
Stratton, Gareth
Handjiev, Svetoslav
Handjieva-Darlenska, Teodora
Navas-Carretero, Santiago
Sundvall, Jouko
Adam, Tanja C
Drummen, Mathijs
Simpson, Elizabeth J
Macdonald, Ian A
Brand-Miller, Jennie
Muirhead, Roslyn
Lam, Tony
Vestentoft, Pia S
Færch, Kristine
Martinez, J Alfredo
Fogelholm, Mikael
Raben, Anne
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Zhu, Ruixin
Craciun, Ionut
Bernhards-Werge, Jan
Jalo, Elli
Poppitt, Sally D
Silvestre, Marta P
Huttunen-Lenz, Maija
McNarry, Melitta A
Stratton, Gareth
Handjiev, Svetoslav
Handjieva-Darlenska, Teodora
Navas-Carretero, Santiago
Sundvall, Jouko
Adam, Tanja C
Drummen, Mathijs
Simpson, Elizabeth J
Macdonald, Ian A
Brand-Miller, Jennie
Muirhead, Roslyn
Lam, Tony
Vestentoft, Pia S
Færch, Kristine
Martinez, J Alfredo
Fogelholm, Mikael
Raben, Anne
dc.subject.por.fl_str_mv Cardiovascular disease
Men
Middle-aged people
Obesity
Older people
Weight loss
Weight loss maintenance
Women
Young people
SDG 3 - Good Health and Well-being
topic Cardiovascular disease
Men
Middle-aged people
Obesity
Older people
Weight loss
Weight loss maintenance
Women
Young people
SDG 3 - Good Health and Well-being
description Funding: Open Access funding provided by University of Helsinki including Helsinki University Central Hospital. This research was supported by the EU Seventh Framework Programme (FP7; 2007– 2013) (grant no. 312057); National Health and Medical Research Council (EU Collaborative Grant AUS 8, ID 1067711); Glycemic Diabetologia Index Foundation Australia through royalties to the University of Sydney; Health Research Council of New Zealand (grant no. 14/191) and University of Auckland Faculty Research Development Fund; Cambridge Weight Plan, which donated all products for the 8 week weight loss period; Danish Agriculture & Food Council; Danish Meat Research Institute; National Institute for Health Research Biomedical Research Centre (NIHR BRC) (UK); Biotechnology and Biological Sciences Research Council (BBSRC) (UK); Engineering and Physical Sciences Research Council (EPSRC) (UK); Nutritics (Dublin), which donated all dietary analysis software used by the University of Nottingham; Juho Vainio Foundation (Finland); Academy of Finland (grant nos 272376, 314383, 266286 and 314135); Finnish Medical Foundation; Gyllenberg Foundation (Finland); Novo Nordisk Foundation; Finnish Diabetes Research Foundation; University of Helsinki; Government Research Funds for Helsinki University Hospital; Jenny and Antti Wihuri Foundation (Finland); Emil Aaltonen Foundation (Finland); and China Scholarship Council. The funders were not involved in the design of the study, the collection, analysis and interpretation of the data or writing of the report and did not impose any restrictions regarding the publication of the report.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-07T22:27:56Z
2022-08
2022-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/141562
url http://hdl.handle.net/10362/141562
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0012-186X
PURE: 45210721
https://doi.org/10.1007/s00125-022-05716-3
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799138097943805952