Association of cyclosporine and mycophenolate mofetil in the treatment of steroid and cyclosporine resistant focal segmental glomerulosclerosis

Detalhes bibliográficos
Autor(a) principal: Viegas,Marcio
Data de Publicação: 2015
Outros Autores: Candido,Cristina, Parreira,Lucia, Assunção,Jose, Vinhas,José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100013
Resumo: Background: Focal and segmental glomerulosclerosis is a common cause of nephrotic syndrome. In cases of steroid and cyclosporine resistance several alternatives have been suggested, based on limited studies with conflicting results. Several studies in organ transplantation have shown that the association of cyclosporine and mycophenolate mofetil has a synergic immunosuppressive effect. Clinical cases: We present two cases of nephrotic syndrome due to idiopathic focal segmental glomerulosclerosis with resistance to steroids, cyclosporine plus low -dose steroids and to mycophenolate mofetil in monotherapy in one of them, where complete remission was achieved with the association of cyclosporine and mycophenolate mofetil. There were no significant complications or renal failure during follow-up in both cases. Conclusion: Combined therapy with cyclosporine and mycophenolate mofetil appears to be effective and safe in the treatment of steroid and cyclosporine resistant idiopathic focal segmental glomerulosclerosis
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spelling Association of cyclosporine and mycophenolate mofetil in the treatment of steroid and cyclosporine resistant focal segmental glomerulosclerosisCyclosporineidiopathic focal and segmental glomerulosclerosismycophenolate mofetilBackground: Focal and segmental glomerulosclerosis is a common cause of nephrotic syndrome. In cases of steroid and cyclosporine resistance several alternatives have been suggested, based on limited studies with conflicting results. Several studies in organ transplantation have shown that the association of cyclosporine and mycophenolate mofetil has a synergic immunosuppressive effect. Clinical cases: We present two cases of nephrotic syndrome due to idiopathic focal segmental glomerulosclerosis with resistance to steroids, cyclosporine plus low -dose steroids and to mycophenolate mofetil in monotherapy in one of them, where complete remission was achieved with the association of cyclosporine and mycophenolate mofetil. There were no significant complications or renal failure during follow-up in both cases. Conclusion: Combined therapy with cyclosporine and mycophenolate mofetil appears to be effective and safe in the treatment of steroid and cyclosporine resistant idiopathic focal segmental glomerulosclerosisSociedade Portuguesa de Nefrologia2015-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100013Portuguese Journal of Nephrology & Hypertension v.29 n.1 2015reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100013Viegas,MarcioCandido,CristinaParreira,LuciaAssunção,JoseVinhas,Joséinfo:eu-repo/semantics/openAccess2024-02-06T17:04:48Zoai:scielo:S0872-01692015000100013Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:54.327105Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Association of cyclosporine and mycophenolate mofetil in the treatment of steroid and cyclosporine resistant focal segmental glomerulosclerosis
title Association of cyclosporine and mycophenolate mofetil in the treatment of steroid and cyclosporine resistant focal segmental glomerulosclerosis
spellingShingle Association of cyclosporine and mycophenolate mofetil in the treatment of steroid and cyclosporine resistant focal segmental glomerulosclerosis
Viegas,Marcio
Cyclosporine
idiopathic focal and segmental glomerulosclerosis
mycophenolate mofetil
title_short Association of cyclosporine and mycophenolate mofetil in the treatment of steroid and cyclosporine resistant focal segmental glomerulosclerosis
title_full Association of cyclosporine and mycophenolate mofetil in the treatment of steroid and cyclosporine resistant focal segmental glomerulosclerosis
title_fullStr Association of cyclosporine and mycophenolate mofetil in the treatment of steroid and cyclosporine resistant focal segmental glomerulosclerosis
title_full_unstemmed Association of cyclosporine and mycophenolate mofetil in the treatment of steroid and cyclosporine resistant focal segmental glomerulosclerosis
title_sort Association of cyclosporine and mycophenolate mofetil in the treatment of steroid and cyclosporine resistant focal segmental glomerulosclerosis
author Viegas,Marcio
author_facet Viegas,Marcio
Candido,Cristina
Parreira,Lucia
Assunção,Jose
Vinhas,José
author_role author
author2 Candido,Cristina
Parreira,Lucia
Assunção,Jose
Vinhas,José
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Viegas,Marcio
Candido,Cristina
Parreira,Lucia
Assunção,Jose
Vinhas,José
dc.subject.por.fl_str_mv Cyclosporine
idiopathic focal and segmental glomerulosclerosis
mycophenolate mofetil
topic Cyclosporine
idiopathic focal and segmental glomerulosclerosis
mycophenolate mofetil
description Background: Focal and segmental glomerulosclerosis is a common cause of nephrotic syndrome. In cases of steroid and cyclosporine resistance several alternatives have been suggested, based on limited studies with conflicting results. Several studies in organ transplantation have shown that the association of cyclosporine and mycophenolate mofetil has a synergic immunosuppressive effect. Clinical cases: We present two cases of nephrotic syndrome due to idiopathic focal segmental glomerulosclerosis with resistance to steroids, cyclosporine plus low -dose steroids and to mycophenolate mofetil in monotherapy in one of them, where complete remission was achieved with the association of cyclosporine and mycophenolate mofetil. There were no significant complications or renal failure during follow-up in both cases. Conclusion: Combined therapy with cyclosporine and mycophenolate mofetil appears to be effective and safe in the treatment of steroid and cyclosporine resistant idiopathic focal segmental glomerulosclerosis
publishDate 2015
dc.date.none.fl_str_mv 2015-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100013
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.29 n.1 2015
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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