Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/18294 |
Resumo: | © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins |
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Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremiaAIDSB-cell activating factorB-cellsHIV-2immune activationmemory B-cells© 2012 Wolters Kluwer Health | Lippincott Williams & WilkinsObjective: Memory B-cell loss has long been recognized as an important contributor to HIV immunodeficiency. HIV-2 infection, which is characterized by a slow rate of progression to AIDS and reduced to undetectable viremia, provides a unique model to investigate B-cell disturbances. Design and methods: B-cell subsets were evaluated in 38 HIV-2-infected individuals, along with markers of T-cell activation and serum levels of immunoglobulins and a major B-cell homeostatic cytokine, B-cell activating factor (BAFF). Untreated HIV-1-infected and seronegative control individuals were studied in parallel. Statistical analysis was performed using Mann–Whitney tests and Spearman's correlations. Results: We found that HIV-2 was associated with significant depletion of both unswitched (CD27+IgD+) and switched (CD27+IgDneg) memory B-cells that directly correlated with T-cell activation, even in individuals with undetectable plasma viral load. Nevertheless, the presence of detectable viremia, even at low levels, was associated with significant memory B-cell loss and higher BAFF levels. Moreover, these alterations were not recovered by antiretroviral-therapy, as treated HIV-2-infected patients showed more pronounced B-cell disturbances, possibly related to their extended length of infection. Conclusion: These first data regarding B-cell imbalances during HIV-2 infection show that, irrespective of viremia, prolonged HIV infection leads to irreversible damage of memory B-cell homeostasis.This work was supported by grant (PIC/IC/82712/2007) from ‘Fundação para a Ciência e a Tecnologia’ (FCT) and by ‘Programa Operacional Ciência e Inovação 2010’ (POCI2010), as well as by Fundaçao Calouste Gulbenkian to AES. RT, RBF, RSS, and RC received scholarships from FCT.Lippincott Williams & WilkinsRepositório da Universidade de LisboaTendeiro, R.Fernandes, S.Foxall, R. B.Marcelino, J. M.Taveira, N.Soares, R. S.Baptista, A. P.Cavaleiro, R.Gomes, P.Victorino, R. M.Sousa, A. E.2015-06-17T10:52:26Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/18294engAIDS 2012, 26:1607–16170269-9370http://journals.lww.com/aidsonline/Fulltext/2012/08240/Memory_B_cell_depletion_is_a_feature_of_HIV_2.3.aspxmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:04:30Zoai:repositorio.ul.pt:10451/18294Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:53.377715Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia |
| title |
Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia |
| spellingShingle |
Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia Tendeiro, R. AIDS B-cell activating factor B-cells HIV-2 immune activation memory B-cells |
| title_short |
Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia |
| title_full |
Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia |
| title_fullStr |
Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia |
| title_full_unstemmed |
Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia |
| title_sort |
Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia |
| author |
Tendeiro, R. |
| author_facet |
Tendeiro, R. Fernandes, S. Foxall, R. B. Marcelino, J. M. Taveira, N. Soares, R. S. Baptista, A. P. Cavaleiro, R. Gomes, P. Victorino, R. M. Sousa, A. E. |
| author_role |
author |
| author2 |
Fernandes, S. Foxall, R. B. Marcelino, J. M. Taveira, N. Soares, R. S. Baptista, A. P. Cavaleiro, R. Gomes, P. Victorino, R. M. Sousa, A. E. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Tendeiro, R. Fernandes, S. Foxall, R. B. Marcelino, J. M. Taveira, N. Soares, R. S. Baptista, A. P. Cavaleiro, R. Gomes, P. Victorino, R. M. Sousa, A. E. |
| dc.subject.por.fl_str_mv |
AIDS B-cell activating factor B-cells HIV-2 immune activation memory B-cells |
| topic |
AIDS B-cell activating factor B-cells HIV-2 immune activation memory B-cells |
| description |
© 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2012-01-01T00:00:00Z 2015-06-17T10:52:26Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/18294 |
| url |
http://hdl.handle.net/10451/18294 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
AIDS 2012, 26:1607–1617 0269-9370 http://journals.lww.com/aidsonline/Fulltext/2012/08240/Memory_B_cell_depletion_is_a_feature_of_HIV_2.3.aspx |
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metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
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Lippincott Williams & Wilkins |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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