Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/78769 |
Resumo: | The administration of a drug-loaded implantable hydrogel at the tumor site after surgical resection is a viable approach to prevent the local recurrence or metastasis. Dimyristoyl glycerophosphorylglycerol (DMPG)-based liposomes were developed for inducing the rapid gelation of silk fibroin (SF) and delivering an anticancer drug, curcumin. Curcumin was loaded in the liposomes and the stability of curcumin was enhanced. The gelation time of liposome-induced SF hydrogels ranged from 3 min to more than 6 h. The biological activity of liposome-SFhydrogels was evaluated in vitro using L929 fibroblasts and MDA-MB-231 breast cancer cells. The release of curcumin can inhibit the growth of cancer cells. Both cells cultured on the surface of the hydrogels loaded with curcumin displayed low cell survival due to the combination of low cell attachment and cytotoxicity of curcumin. Liposome-SF hydrogels show potential as a sealant administered at the tumor site to eliminate residual cancer cells after tumor removal. |
id |
RCAP_f8f27de44599b8d23552ac5d41a0c900 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/78769 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formationAnticancerCurcuminHydrogelLiposomeSilk fibroinScience & TechnologyThe administration of a drug-loaded implantable hydrogel at the tumor site after surgical resection is a viable approach to prevent the local recurrence or metastasis. Dimyristoyl glycerophosphorylglycerol (DMPG)-based liposomes were developed for inducing the rapid gelation of silk fibroin (SF) and delivering an anticancer drug, curcumin. Curcumin was loaded in the liposomes and the stability of curcumin was enhanced. The gelation time of liposome-induced SF hydrogels ranged from 3 min to more than 6 h. The biological activity of liposome-SFhydrogels was evaluated in vitro using L929 fibroblasts and MDA-MB-231 breast cancer cells. The release of curcumin can inhibit the growth of cancer cells. Both cells cultured on the surface of the hydrogels loaded with curcumin displayed low cell survival due to the combination of low cell attachment and cytotoxicity of curcumin. Liposome-SF hydrogels show potential as a sealant administered at the tumor site to eliminate residual cancer cells after tumor removal.An International Cooperative Graduate School (ICGS) Fellowship under the "Chulalongkorn University -NIMS Cooperative Graduate School Program" was acknowledged for supporting the exchange student to conduct the collaborative research project. The PhD grants for Chavee Laomeephol were supported by "The 100th Anniversary Chulalongkorn University Fund for Doctoral Scholarship" and "The 90th Anniversary Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund)". TEM observation was kindly supported by NIMS microstructural characterization platform, and DLS and LC/MS measurements were supported by NIMS molecule & materials synthesis platform as a program of "Nanotechnology Platform" of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.ElsevierUniversidade do MinhoLaomeephol, ChaveeFerreira, Helena Susana Costa MachadoKanokpanont, SoradaNeves, N. M.Kobayashi, HisatoshiDamrongsakkul, Siriporn2020-112020-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/78769engLaomeephol C., Ferreira H., Kanokpanont S., Neves N. M., Kobayashi H., Damrongsakkul S. Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation, International Journal of Pharmaceutics, Vol. 589, pp. 119844, doi:10.1016/j.ijpharm.2020.119844, 20200378-517310.1016/j.ijpharm.2020.11984432905796https://www.sciencedirect.com/science/article/pii/S0378517320308292info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-07T01:22:23Zoai:repositorium.sdum.uminho.pt:1822/78769Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:54:05.515584Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation |
title |
Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation |
spellingShingle |
Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation Laomeephol, Chavee Anticancer Curcumin Hydrogel Liposome Silk fibroin Science & Technology |
title_short |
Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation |
title_full |
Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation |
title_fullStr |
Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation |
title_full_unstemmed |
Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation |
title_sort |
Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation |
author |
Laomeephol, Chavee |
author_facet |
Laomeephol, Chavee Ferreira, Helena Susana Costa Machado Kanokpanont, Sorada Neves, N. M. Kobayashi, Hisatoshi Damrongsakkul, Siriporn |
author_role |
author |
author2 |
Ferreira, Helena Susana Costa Machado Kanokpanont, Sorada Neves, N. M. Kobayashi, Hisatoshi Damrongsakkul, Siriporn |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Laomeephol, Chavee Ferreira, Helena Susana Costa Machado Kanokpanont, Sorada Neves, N. M. Kobayashi, Hisatoshi Damrongsakkul, Siriporn |
dc.subject.por.fl_str_mv |
Anticancer Curcumin Hydrogel Liposome Silk fibroin Science & Technology |
topic |
Anticancer Curcumin Hydrogel Liposome Silk fibroin Science & Technology |
description |
The administration of a drug-loaded implantable hydrogel at the tumor site after surgical resection is a viable approach to prevent the local recurrence or metastasis. Dimyristoyl glycerophosphorylglycerol (DMPG)-based liposomes were developed for inducing the rapid gelation of silk fibroin (SF) and delivering an anticancer drug, curcumin. Curcumin was loaded in the liposomes and the stability of curcumin was enhanced. The gelation time of liposome-induced SF hydrogels ranged from 3 min to more than 6 h. The biological activity of liposome-SFhydrogels was evaluated in vitro using L929 fibroblasts and MDA-MB-231 breast cancer cells. The release of curcumin can inhibit the growth of cancer cells. Both cells cultured on the surface of the hydrogels loaded with curcumin displayed low cell survival due to the combination of low cell attachment and cytotoxicity of curcumin. Liposome-SF hydrogels show potential as a sealant administered at the tumor site to eliminate residual cancer cells after tumor removal. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11 2020-11-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/78769 |
url |
https://hdl.handle.net/1822/78769 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Laomeephol C., Ferreira H., Kanokpanont S., Neves N. M., Kobayashi H., Damrongsakkul S. Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation, International Journal of Pharmaceutics, Vol. 589, pp. 119844, doi:10.1016/j.ijpharm.2020.119844, 2020 0378-5173 10.1016/j.ijpharm.2020.119844 32905796 https://www.sciencedirect.com/science/article/pii/S0378517320308292 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133138942689280 |