Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species

Detalhes bibliográficos
Autor(a) principal: Hauser, Philippe M.
Data de Publicação: 2022
Outros Autores: Almeida, João M.G.C.F., Richard, Sophie, Meier, Caroline S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/151295
Resumo: Funding Information: We thank Aaron Albee, University of Cincinnati, for having pointed out Itatani’s work to us. P.H.M.’s research is presently funded by the Swiss National Science Foundation (grant 310030_ 192802). The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. We have no conflicts of interest to declare. Publisher Copyright: © 2022 Hauser et al.
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spelling Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Speciesgenetic diversitymycosisnuclear fusionobligate biotrophic parasitesexual developmenttrophic formMicrobiologyVirologyFunding Information: We thank Aaron Albee, University of Cincinnati, for having pointed out Itatani’s work to us. P.H.M.’s research is presently funded by the Swiss National Science Foundation (grant 310030_ 192802). The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. We have no conflicts of interest to declare. Publisher Copyright: © 2022 Hauser et al.Pneumocystis species are obligate fungal biotrophs that colonize the lungs of mammals. They cause deadly pneumonia in immunocompromised hosts. The sexual phase seems obligate during their life cycle and essential for survival because it is believed to ensure proliferation and transmission between hosts. Here, we consider if the sexual phase is initiated by the fusion of two cells or by nucleus duplication in order to generate diploid cells that can undergo meiosis. The juxtaposition of the nucleus-associated organelles of pairs of cells with fused cytoplasmic membranes demonstrated that cell fusion can occur. Nevertheless, the frequency of cell fusion remains to be determined, and it cannot be excluded that both cell fusion and nucleus duplication are used to ensure the occurrence of the essential sexual phase. In vitro culturing of these fungi is a major milestone that could clarify the issue.UCIBIO - Applied Molecular Biosciences UnitRUNHauser, Philippe M.Almeida, João M.G.C.F.Richard, SophieMeier, Caroline S.2023-03-27T22:15:14Z2022-082022-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/151295engHauser, P. M., Almeida, J. M. G. C. F., Richard, S., & Meier, C. S. (2022). Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species. mBio, 13(4). https://doi.org/10.1128/mbio.00859-222161-2129PURE: 57075248https://doi.org/10.1128/mbio.00859-22info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:33:42Zoai:run.unl.pt:10362/151295Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:31.199481Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species
title Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species
spellingShingle Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species
Hauser, Philippe M.
genetic diversity
mycosis
nuclear fusion
obligate biotrophic parasite
sexual development
trophic form
Microbiology
Virology
title_short Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species
title_full Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species
title_fullStr Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species
title_full_unstemmed Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species
title_sort Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species
author Hauser, Philippe M.
author_facet Hauser, Philippe M.
Almeida, João M.G.C.F.
Richard, Sophie
Meier, Caroline S.
author_role author
author2 Almeida, João M.G.C.F.
Richard, Sophie
Meier, Caroline S.
author2_role author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
RUN
dc.contributor.author.fl_str_mv Hauser, Philippe M.
Almeida, João M.G.C.F.
Richard, Sophie
Meier, Caroline S.
dc.subject.por.fl_str_mv genetic diversity
mycosis
nuclear fusion
obligate biotrophic parasite
sexual development
trophic form
Microbiology
Virology
topic genetic diversity
mycosis
nuclear fusion
obligate biotrophic parasite
sexual development
trophic form
Microbiology
Virology
description Funding Information: We thank Aaron Albee, University of Cincinnati, for having pointed out Itatani’s work to us. P.H.M.’s research is presently funded by the Swiss National Science Foundation (grant 310030_ 192802). The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. We have no conflicts of interest to declare. Publisher Copyright: © 2022 Hauser et al.
publishDate 2022
dc.date.none.fl_str_mv 2022-08
2022-08-01T00:00:00Z
2023-03-27T22:15:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/151295
url http://hdl.handle.net/10362/151295
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Hauser, P. M., Almeida, J. M. G. C. F., Richard, S., & Meier, C. S. (2022). Cell Fusion May Be Involved in the Homothallic Mating of Pneumocystis Species. mBio, 13(4). https://doi.org/10.1128/mbio.00859-22
2161-2129
PURE: 57075248
https://doi.org/10.1128/mbio.00859-22
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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