Effector memory CD4(+) T cells are associated with cognitive performance in a senior population
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.23/1021 |
Resumo: | OBJECTIVE: Immunosenescence and cognitive decline are common markers of the aging process. Taking into consideration the heterogeneity observed in aging processes and the recently described link between lymphocytes and cognition, we herein explored the possibility of an association between alterations in lymphocytic populations and cognitive performance. METHODS: In a cohort of cognitively healthy adults (n = 114), previously characterized by diverse neurocognitive/psychological performance patterns, detailed peripheral blood immunophenotyping of both the innate and adaptive immune systems was performed by flow cytometry. RESULTS: Better cognitive performance was associated with lower numbers of effector memory CD4(+) T cells and higher numbers of naive CD8(+) T cells and B cells. Furthermore, effector memory CD4(+) T cells were found to be predictors of general and executive function and memory, even when factors known to influence cognitive performance in older individuals (e.g., age, sex, education, and mood) were taken into account. CONCLUSIONS: This is the first study in humans associating specific phenotypes of the immune system with distinct cognitive performance in healthy aging. |
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Effector memory CD4(+) T cells are associated with cognitive performance in a senior populationEnvelhecimentoImunossenescênciaLinfócitos T CD4-PositivosCogniçãoOBJECTIVE: Immunosenescence and cognitive decline are common markers of the aging process. Taking into consideration the heterogeneity observed in aging processes and the recently described link between lymphocytes and cognition, we herein explored the possibility of an association between alterations in lymphocytic populations and cognitive performance. METHODS: In a cohort of cognitively healthy adults (n = 114), previously characterized by diverse neurocognitive/psychological performance patterns, detailed peripheral blood immunophenotyping of both the innate and adaptive immune systems was performed by flow cytometry. RESULTS: Better cognitive performance was associated with lower numbers of effector memory CD4(+) T cells and higher numbers of naive CD8(+) T cells and B cells. Furthermore, effector memory CD4(+) T cells were found to be predictors of general and executive function and memory, even when factors known to influence cognitive performance in older individuals (e.g., age, sex, education, and mood) were taken into account. CONCLUSIONS: This is the first study in humans associating specific phenotypes of the immune system with distinct cognitive performance in healthy aging.Repositório Científico do Hospital de BragaSerre-Miranda, CRoque, SSantos, NCPortugal-Nunes, CCosta, PPalha, JASousa, NCorreia-Neves, M2016-05-04T11:53:08Z2015-02-01T00:00:00Z2015-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/1021engNeurol Neuroimmunol Neuroinflamm. 2014 Dec 23;2(1):e54.10.1212/NXI.0000000000000054info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:02:49Zoai:repositorio.hospitaldebraga.pt:10400.23/1021Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:35.758201Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effector memory CD4(+) T cells are associated with cognitive performance in a senior population |
title |
Effector memory CD4(+) T cells are associated with cognitive performance in a senior population |
spellingShingle |
Effector memory CD4(+) T cells are associated with cognitive performance in a senior population Serre-Miranda, C Envelhecimento Imunossenescência Linfócitos T CD4-Positivos Cognição |
title_short |
Effector memory CD4(+) T cells are associated with cognitive performance in a senior population |
title_full |
Effector memory CD4(+) T cells are associated with cognitive performance in a senior population |
title_fullStr |
Effector memory CD4(+) T cells are associated with cognitive performance in a senior population |
title_full_unstemmed |
Effector memory CD4(+) T cells are associated with cognitive performance in a senior population |
title_sort |
Effector memory CD4(+) T cells are associated with cognitive performance in a senior population |
author |
Serre-Miranda, C |
author_facet |
Serre-Miranda, C Roque, S Santos, NC Portugal-Nunes, C Costa, P Palha, JA Sousa, N Correia-Neves, M |
author_role |
author |
author2 |
Roque, S Santos, NC Portugal-Nunes, C Costa, P Palha, JA Sousa, N Correia-Neves, M |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Hospital de Braga |
dc.contributor.author.fl_str_mv |
Serre-Miranda, C Roque, S Santos, NC Portugal-Nunes, C Costa, P Palha, JA Sousa, N Correia-Neves, M |
dc.subject.por.fl_str_mv |
Envelhecimento Imunossenescência Linfócitos T CD4-Positivos Cognição |
topic |
Envelhecimento Imunossenescência Linfócitos T CD4-Positivos Cognição |
description |
OBJECTIVE: Immunosenescence and cognitive decline are common markers of the aging process. Taking into consideration the heterogeneity observed in aging processes and the recently described link between lymphocytes and cognition, we herein explored the possibility of an association between alterations in lymphocytic populations and cognitive performance. METHODS: In a cohort of cognitively healthy adults (n = 114), previously characterized by diverse neurocognitive/psychological performance patterns, detailed peripheral blood immunophenotyping of both the innate and adaptive immune systems was performed by flow cytometry. RESULTS: Better cognitive performance was associated with lower numbers of effector memory CD4(+) T cells and higher numbers of naive CD8(+) T cells and B cells. Furthermore, effector memory CD4(+) T cells were found to be predictors of general and executive function and memory, even when factors known to influence cognitive performance in older individuals (e.g., age, sex, education, and mood) were taken into account. CONCLUSIONS: This is the first study in humans associating specific phenotypes of the immune system with distinct cognitive performance in healthy aging. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02-01T00:00:00Z 2015-02-01T00:00:00Z 2016-05-04T11:53:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.23/1021 |
url |
http://hdl.handle.net/10400.23/1021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neurol Neuroimmunol Neuroinflamm. 2014 Dec 23;2(1):e54. 10.1212/NXI.0000000000000054 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130424388091904 |