Determinants of HIV-1 late presentation in patients followed in europe

Detalhes bibliográficos
Autor(a) principal: Miranda, Mafalda N.S.
Data de Publicação: 2021
Outros Autores: Pingarilho, Marta, Pimentel, Victor, Martins, Maria Do Rosário O., Vandamme, Anne Mieke, Bobkova, Marina, Böhm, Michael, Seguin-Devaux, Carole, Paredes, Roger, Rubio, Rafael, Zazzi, Maurizio, Incardona, Francesca, Abecasis, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/128853
Resumo: Funding Information: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Ge?nese HIVLatePresenters. Funding Information: Funding: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Geénese HIVLatePresenters. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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spelling Determinants of HIV-1 late presentation in patients followed in europeEuropeHIV-1 infectionLate presentationImmunology and AllergyMolecular BiologyImmunology and Microbiology(all)Microbiology (medical)Infectious DiseasesSDG 3 - Good Health and Well-beingSDG 10 - Reduced InequalitiesMicrobiologia MédicaFunding Information: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Ge?nese HIVLatePresenters. Funding Information: Funding: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Geénese HIVLatePresenters. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.To control the Human Immunodeficiency Virus (HIV) pandemic, the World Health Organization (WHO) set the 90-90-90 target to be reached by 2020. One major threat to those goals is late presentation, which is defined as an individual presenting a TCD4+ count lower than 350 cells/mm3 or an AIDS-defining event. The present study aims to identify determinants of late presentation in Europe based on the EuResist database with HIV-1 infected patients followed-up between 1981 and 2019. Our study includes clinical and socio-demographic information from 89,851 HIV-1 infected patients. Statistical analysis was performed using RStudio and SPSS and a Bayesian network was constructed with the WEKA software to analyze the association between all variables. Among 89851 HIV-1 infected patients included in the analysis, the median age was 33 (IQR: 27.0–41.0) years and 74.4% were males. Of those, 28,889 patients (50.4%) were late presenters. Older patients (>56), heterosexuals, patients originated from Africa and patients presenting with log VL >4.1 had a higher probability of being late presenters (p < 0.001). Bayesian networks indicated VL, mode of transmis-sion, age and recentness of infection as variables that were directly associated with LP. This study highlights the major determinants associated with late presentation in Europe. This study helps to direct prevention measures for this population.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)TB, HIV and opportunistic diseases and pathogens (THOP)Population health, policies and services (PPS)RUNMiranda, Mafalda N.S.Pingarilho, MartaPimentel, VictorMartins, Maria Do Rosário O.Vandamme, Anne MiekeBobkova, MarinaBöhm, MichaelSeguin-Devaux, CaroleParedes, RogerRubio, RafaelZazzi, MaurizioIncardona, FrancescaAbecasis, Ana2021-12-07T23:42:28Z2021-072021-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttp://hdl.handle.net/10362/128853eng2076-0817PURE: 33047814https://doi.org/10.3390/pathogens10070835info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:08:12Zoai:run.unl.pt:10362/128853Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:46:24.839856Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Determinants of HIV-1 late presentation in patients followed in europe
title Determinants of HIV-1 late presentation in patients followed in europe
spellingShingle Determinants of HIV-1 late presentation in patients followed in europe
Miranda, Mafalda N.S.
Europe
HIV-1 infection
Late presentation
Immunology and Allergy
Molecular Biology
Immunology and Microbiology(all)
Microbiology (medical)
Infectious Diseases
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
Microbiologia Médica
title_short Determinants of HIV-1 late presentation in patients followed in europe
title_full Determinants of HIV-1 late presentation in patients followed in europe
title_fullStr Determinants of HIV-1 late presentation in patients followed in europe
title_full_unstemmed Determinants of HIV-1 late presentation in patients followed in europe
title_sort Determinants of HIV-1 late presentation in patients followed in europe
author Miranda, Mafalda N.S.
author_facet Miranda, Mafalda N.S.
Pingarilho, Marta
Pimentel, Victor
Martins, Maria Do Rosário O.
Vandamme, Anne Mieke
Bobkova, Marina
Böhm, Michael
Seguin-Devaux, Carole
Paredes, Roger
Rubio, Rafael
Zazzi, Maurizio
Incardona, Francesca
Abecasis, Ana
author_role author
author2 Pingarilho, Marta
Pimentel, Victor
Martins, Maria Do Rosário O.
Vandamme, Anne Mieke
Bobkova, Marina
Böhm, Michael
Seguin-Devaux, Carole
Paredes, Roger
Rubio, Rafael
Zazzi, Maurizio
Incardona, Francesca
Abecasis, Ana
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
TB, HIV and opportunistic diseases and pathogens (THOP)
Population health, policies and services (PPS)
RUN
dc.contributor.author.fl_str_mv Miranda, Mafalda N.S.
Pingarilho, Marta
Pimentel, Victor
Martins, Maria Do Rosário O.
Vandamme, Anne Mieke
Bobkova, Marina
Böhm, Michael
Seguin-Devaux, Carole
Paredes, Roger
Rubio, Rafael
Zazzi, Maurizio
Incardona, Francesca
Abecasis, Ana
dc.subject.por.fl_str_mv Europe
HIV-1 infection
Late presentation
Immunology and Allergy
Molecular Biology
Immunology and Microbiology(all)
Microbiology (medical)
Infectious Diseases
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
Microbiologia Médica
topic Europe
HIV-1 infection
Late presentation
Immunology and Allergy
Molecular Biology
Immunology and Microbiology(all)
Microbiology (medical)
Infectious Diseases
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
Microbiologia Médica
description Funding Information: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Ge?nese HIVLatePresenters. Funding Information: Funding: This study was financed by FCT through the following projects: GHTM-UID/04413/2020, INTEGRIV (PTDC/SAU-INF/31990/2017) and the scholarship PD/BD/135714/2018 and Gilead Geénese HIVLatePresenters. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-07T23:42:28Z
2021-07
2021-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/128853
url http://hdl.handle.net/10362/128853
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-0817
PURE: 33047814
https://doi.org/10.3390/pathogens10070835
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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