APOE genotypes and dyslipidemias in a sample of the Portuguese population
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/337 |
Resumo: | The objective of this work was to study the distribution of apolipoprotein E (APOE) genotypes in a sample of the Portuguese population, and its association with the dyslipidemias observed. Study participants were healthy users of local Public Health Laboratories in six regions of mainland Portugal (Porto, Vila Real, Viseu, Lisboa, Portalegre and Faro). A total of 779 men and 1153 women aged 15-74 years agreed to participate. Fasting lipid levels and APOE genotypes were determined centrally at the National Institute of Health in Lisboa. The frequency distribution of APOE alleles was: epsilon2=5.3%, epsilon3=84.9% and epsilon4=9.8%. Dyslipidemias were present in 66.6% of men and 60.7% of women. Comparison of APOE genotypes and relative allele frequencies showed that in dyslipidemic compared to normolipidemic subjects, the epsilon4 allele was more frequent in both sexes, although in a more pronounced way in men than in women due to higher frequencies of epsilon3/epsilon4 and epsilon4/epsilon4 genotypes. The known association of the epsilon4 allele with high cholesterol levels, the association of the epsilon2 allele with low cholesterol levels, and the association of the epsilon2 allele with high levels of triglycerides and low levels of high-density lipoprotein-cholesterol were confirmed in this study. |
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APOE genotypes and dyslipidemias in a sample of the Portuguese populationAPOE genotypesCardiovascular diseasesDyslipidemiasPortuguese regionsDoenças Cardio e Cérebro-vascularesThe objective of this work was to study the distribution of apolipoprotein E (APOE) genotypes in a sample of the Portuguese population, and its association with the dyslipidemias observed. Study participants were healthy users of local Public Health Laboratories in six regions of mainland Portugal (Porto, Vila Real, Viseu, Lisboa, Portalegre and Faro). A total of 779 men and 1153 women aged 15-74 years agreed to participate. Fasting lipid levels and APOE genotypes were determined centrally at the National Institute of Health in Lisboa. The frequency distribution of APOE alleles was: epsilon2=5.3%, epsilon3=84.9% and epsilon4=9.8%. Dyslipidemias were present in 66.6% of men and 60.7% of women. Comparison of APOE genotypes and relative allele frequencies showed that in dyslipidemic compared to normolipidemic subjects, the epsilon4 allele was more frequent in both sexes, although in a more pronounced way in men than in women due to higher frequencies of epsilon3/epsilon4 and epsilon4/epsilon4 genotypes. The known association of the epsilon4 allele with high cholesterol levels, the association of the epsilon2 allele with low cholesterol levels, and the association of the epsilon2 allele with high levels of triglycerides and low levels of high-density lipoprotein-cholesterol were confirmed in this study.Walter de GruyterRepositório Científico do Instituto Nacional de SaúdeRodrigues, M.O.Fonseca, A.Dias, Carlos MatiasAlbergaria, I.Martins, G.Alpendre, M.L.Martins, M. do C.2011-12-05T15:19:14Z2005-092005-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/337engClin Chem Lab Med. 2005;43(9):907-121434-6621doi:10.1515/CCLM.2005.155info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:38:09Zoai:repositorio.insa.pt:10400.18/337Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:35:34.075684Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
APOE genotypes and dyslipidemias in a sample of the Portuguese population |
title |
APOE genotypes and dyslipidemias in a sample of the Portuguese population |
spellingShingle |
APOE genotypes and dyslipidemias in a sample of the Portuguese population Rodrigues, M.O. APOE genotypes Cardiovascular diseases Dyslipidemias Portuguese regions Doenças Cardio e Cérebro-vasculares |
title_short |
APOE genotypes and dyslipidemias in a sample of the Portuguese population |
title_full |
APOE genotypes and dyslipidemias in a sample of the Portuguese population |
title_fullStr |
APOE genotypes and dyslipidemias in a sample of the Portuguese population |
title_full_unstemmed |
APOE genotypes and dyslipidemias in a sample of the Portuguese population |
title_sort |
APOE genotypes and dyslipidemias in a sample of the Portuguese population |
author |
Rodrigues, M.O. |
author_facet |
Rodrigues, M.O. Fonseca, A. Dias, Carlos Matias Albergaria, I. Martins, G. Alpendre, M.L. Martins, M. do C. |
author_role |
author |
author2 |
Fonseca, A. Dias, Carlos Matias Albergaria, I. Martins, G. Alpendre, M.L. Martins, M. do C. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Rodrigues, M.O. Fonseca, A. Dias, Carlos Matias Albergaria, I. Martins, G. Alpendre, M.L. Martins, M. do C. |
dc.subject.por.fl_str_mv |
APOE genotypes Cardiovascular diseases Dyslipidemias Portuguese regions Doenças Cardio e Cérebro-vasculares |
topic |
APOE genotypes Cardiovascular diseases Dyslipidemias Portuguese regions Doenças Cardio e Cérebro-vasculares |
description |
The objective of this work was to study the distribution of apolipoprotein E (APOE) genotypes in a sample of the Portuguese population, and its association with the dyslipidemias observed. Study participants were healthy users of local Public Health Laboratories in six regions of mainland Portugal (Porto, Vila Real, Viseu, Lisboa, Portalegre and Faro). A total of 779 men and 1153 women aged 15-74 years agreed to participate. Fasting lipid levels and APOE genotypes were determined centrally at the National Institute of Health in Lisboa. The frequency distribution of APOE alleles was: epsilon2=5.3%, epsilon3=84.9% and epsilon4=9.8%. Dyslipidemias were present in 66.6% of men and 60.7% of women. Comparison of APOE genotypes and relative allele frequencies showed that in dyslipidemic compared to normolipidemic subjects, the epsilon4 allele was more frequent in both sexes, although in a more pronounced way in men than in women due to higher frequencies of epsilon3/epsilon4 and epsilon4/epsilon4 genotypes. The known association of the epsilon4 allele with high cholesterol levels, the association of the epsilon2 allele with low cholesterol levels, and the association of the epsilon2 allele with high levels of triglycerides and low levels of high-density lipoprotein-cholesterol were confirmed in this study. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-09 2005-09-01T00:00:00Z 2011-12-05T15:19:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/337 |
url |
http://hdl.handle.net/10400.18/337 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clin Chem Lab Med. 2005;43(9):907-12 1434-6621 doi:10.1515/CCLM.2005.155 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Walter de Gruyter |
publisher.none.fl_str_mv |
Walter de Gruyter |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132083086426112 |