Basic science of osteoarthritis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/42617 |
Resumo: | Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option for the treatment of OA and may be used concomitantly with functional substitutes integrating scaffolds and drugs/growth factors in tissue engineering setups. Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA. |
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Basic science of osteoarthritisAnimal modelsArticular cartilageBoneInterfaceOsteoarthritisPathomechanismsStem cellsTissue engineeringOsteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option for the treatment of OA and may be used concomitantly with functional substitutes integrating scaffolds and drugs/growth factors in tissue engineering setups. Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA.(undefined)SpringerOpenUniversidade do MinhoCucchiarini, MagaliGirolamo, Laura deFilardo, GiuseppeOliveira, J. M.Orth, PatrickPape, DietrichReboul, Paul2016-092016-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/42617engCucchiarini M., de Girolamo L., Filardo G., Oliveira J. M., Orth P., Pape D., Reboul P. Basic science of osteoarthritis, Journal of Experimental Orthopaedics, Vol. 3, Issue 22, pp. 1-18, doi:10.1186/s40634-016-0060-6, 20162197-115310.1186/s40634-016-0060-6https://doi.org/10.1186/s40634-016-0060-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:45:58Zoai:repositorium.sdum.uminho.pt:1822/42617Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:43:55.133349Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Basic science of osteoarthritis |
title |
Basic science of osteoarthritis |
spellingShingle |
Basic science of osteoarthritis Cucchiarini, Magali Animal models Articular cartilage Bone Interface Osteoarthritis Pathomechanisms Stem cells Tissue engineering |
title_short |
Basic science of osteoarthritis |
title_full |
Basic science of osteoarthritis |
title_fullStr |
Basic science of osteoarthritis |
title_full_unstemmed |
Basic science of osteoarthritis |
title_sort |
Basic science of osteoarthritis |
author |
Cucchiarini, Magali |
author_facet |
Cucchiarini, Magali Girolamo, Laura de Filardo, Giuseppe Oliveira, J. M. Orth, Patrick Pape, Dietrich Reboul, Paul |
author_role |
author |
author2 |
Girolamo, Laura de Filardo, Giuseppe Oliveira, J. M. Orth, Patrick Pape, Dietrich Reboul, Paul |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Cucchiarini, Magali Girolamo, Laura de Filardo, Giuseppe Oliveira, J. M. Orth, Patrick Pape, Dietrich Reboul, Paul |
dc.subject.por.fl_str_mv |
Animal models Articular cartilage Bone Interface Osteoarthritis Pathomechanisms Stem cells Tissue engineering |
topic |
Animal models Articular cartilage Bone Interface Osteoarthritis Pathomechanisms Stem cells Tissue engineering |
description |
Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option for the treatment of OA and may be used concomitantly with functional substitutes integrating scaffolds and drugs/growth factors in tissue engineering setups. Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09 2016-09-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/42617 |
url |
http://hdl.handle.net/1822/42617 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cucchiarini M., de Girolamo L., Filardo G., Oliveira J. M., Orth P., Pape D., Reboul P. Basic science of osteoarthritis, Journal of Experimental Orthopaedics, Vol. 3, Issue 22, pp. 1-18, doi:10.1186/s40634-016-0060-6, 2016 2197-1153 10.1186/s40634-016-0060-6 https://doi.org/10.1186/s40634-016-0060-6 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SpringerOpen |
publisher.none.fl_str_mv |
SpringerOpen |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132998041337856 |